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Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer

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Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer. / Michailidou, Kyriaki; Beesley, Jonathan; Lindstrom, Sara; Canisius, Sander; Dennis, Joe; Lush, Michael J; Maranian, Mel J; Bolla, Manjeet K; Wang, Qin; Shah, Mitul; Perkins, Barbara J; Czene, Kamila; Eriksson, Mikael; Darabi, Hatef; Brand, Judith S; Bojesen, Stig E; Nordestgaard, Børge G; Flyger, Henrik; Nielsen, Sune F; Rahman, Nazneen; Turnbull, Clare; Fletcher, Olivia; Peto, Julian; Gibson, Lorna; dos-Santos-Silva, Isabel; Chang-Claude, Jenny; Flesch-Janys, Dieter; Rudolph, Anja; Eilber, Ursula; Behrens, Sabine; Nevanlinna, Heli; Muranen, Taru A; Aittomäki, Kristiina; Blomqvist, Carl; Khan, Sofia; Aaltonen, Kirsimari; Ahsan, Habibul; Kibriya, Muhammad G; Whittemore, Alice S; John, Esther M; Malone, Kathleen E; Gammon, Marilie D; Santella, Regina M; Ursin, Giske; Makalic, Enes; Schmidt, Daniel F; Casey, Graham; Hunter, David J; Gapstur, Susan M; Gaudet, Mia M; Diver, W Ryan; Haiman, Christopher A; Schumacher, Fredrick; Henderson, Brian E; Le Marchand, Loic; Berg, Christine D; Chanock, Stephen J; Figueroa, Jonine; Hoover, Robert N; Lambrechts, Diether; Neven, Patrick; Wildiers, Hans; van Limbergen, Erik; Schmidt, Marjanka K; Broeks, Annegien; Verhoef, Senno; Cornelissen, Sten; Couch, Fergus J; Olson, Janet E; Hallberg, Emily; Vachon, Celine; Waisfisz, Quinten; Meijers-Heijboer, Hanne; Adank, Muriel A; van der Luijt, Rob B; Li, Jingmei; Liu, Jianjun; Humphreys, Keith; Kang, Daehee; Choi, Ji-Yeob; Park, Sue K; Yoo, Keun-Young; Matsuo, Keitaro; Ito, Hidemi; Iwata, Hiroji; Tajima, Kazuo; Guénel, Pascal; Truong, Thérèse; Mulot, Claire; Sanchez, Marie; Burwinkel, Barbara; Marme, Frederik; Surowy, Harald; Sohn, Christof; Wu, Anna H; Tseng, Chiu-chen; Van Den Berg, David; Stram, Daniel O; González-Neira, Anna; Benitez, Javier; Zamora, M Pilar; Perez, Jose Ignacio Arias; Shu, Xiao-Ou; Lu, Wei; Gao, Yu-Tang; Cai, Hui; Cox, Angela; Cross, Simon S; Reed, Malcolm W R; Andrulis, Irene L; Knight, Julia A; Glendon, Gord; Mulligan, Anna Marie; Sawyer, Elinor J; Tomlinson, Ian; Kerin, Michael J; Miller, Nicola; Lindblom, Annika; Margolin, Sara; Teo, Soo Hwang; Yip, Cheng Har; Taib, Nur Aishah Mohd; Tan, Gie-Hooi; Hooning, Maartje J; Hollestelle, Antoinette; Martens, John W M; Collée, J Margriet; Blot, William; Signorello, Lisa B; Cai, Qiuyin; Hopper, John L; Southey, Melissa C; Tsimiklis, Helen; Apicella, Carmel; Shen, Chen-Yang; Hsiung, Chia-Ni; Wu, Pei-Ei; Hou, Ming-Feng; Kristensen, Vessela N; Nord, Silje; Alnaes, Grethe I Grenaker; Giles, Graham G; Milne, Roger L; McLean, Catriona; Canzian, Federico; Trichopoulos, Dimitrios; Peeters, Petra; Lund, Eiliv; Sund, Malin; Khaw, Kay-Tee; Gunter, Marc J; Palli, Domenico; Mortensen, Lotte Maxild; Dossus, Laure; Huerta, Jose-Maria; Meindl, Alfons; Schmutzler, Rita K; Sutter, Christian; Yang, Rongxi; Muir, Kenneth; Lophatananon, Artitaya; Stewart-Brown, Sarah; Siriwanarangsan, Pornthep; Hartman, Mikael; Miao, Hui; Chia, Kee Seng; Chan, Ching Wan; Fasching, Peter A; Hein, Alexander; Beckmann, Matthias W; Haeberle, Lothar; Brenner, Hermann; Dieffenbach, Aida Karina; Arndt, Volker; Stegmaier, Christa; Ashworth, Alan; Orr, Nick; Schoemaker, Minouk J; Swerdlow, Anthony J; Brinton, Louise; Garcia-Closas, Montserrat; Zheng, Wei; Halverson, Sandra L; Shrubsole, Martha; Long, Jirong; Goldberg, Mark S; Labrèche, France; Dumont, Martine; Winqvist, Robert; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Grip, Mervi; Brauch, Hiltrud; Hamann, Ute; Brüning, Thomas; Radice, Paolo; Peterlongo, Paolo; Manoukian, Siranoush; Bernard, Loris; Bogdanova, Natalia V; Dörk, Thilo; Mannermaa, Arto; Kataja, Vesa; Kosma, Veli-Matti; Hartikainen, Jaana M; Devilee, Peter; Tollenaar, Robert A E M; Seynaeve, Caroline; Van Asperen, Christi J; Jakubowska, Anna; Lubinski, Jan; Jaworska, Katarzyna; Huzarski, Tomasz; Sangrajrang, Suleeporn; Gaborieau, Valerie; Brennan, Paul; McKay, James; Slager, Susan; Toland, Amanda E; Ambrosone, Christine B; Yannoukakos, Drakoulis; Kabisch, Maria; Torres, Diana; Neuhausen, Susan L; Anton-Culver, Hoda; Luccarini, Craig; Baynes, Caroline; Ahmed, Shahana; Healey, Catherine S; Tessier, Daniel C; Vincent, Daniel; Bacot, Francois; Pita, Guillermo; Alonso, M Rosario; Álvarez, Nuria; Herrero, Daniel; Simard, Jacques; Pharoah, Paul P D P; Kraft, Peter; Dunning, Alison M; Chenevix-Trench, Georgia; Hall, Per; Easton, Douglas F; BOCS.

in: NAT GENET, Jahrgang 47, Nr. 4, 04.2015, S. 373-80.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Michailidou, K, Beesley, J, Lindstrom, S, Canisius, S, Dennis, J, Lush, MJ, Maranian, MJ, Bolla, MK, Wang, Q, Shah, M, Perkins, BJ, Czene, K, Eriksson, M, Darabi, H, Brand, JS, Bojesen, SE, Nordestgaard, BG, Flyger, H, Nielsen, SF, Rahman, N, Turnbull, C, Fletcher, O, Peto, J, Gibson, L, dos-Santos-Silva, I, Chang-Claude, J, Flesch-Janys, D, Rudolph, A, Eilber, U, Behrens, S, Nevanlinna, H, Muranen, TA, Aittomäki, K, Blomqvist, C, Khan, S, Aaltonen, K, Ahsan, H, Kibriya, MG, Whittemore, AS, John, EM, Malone, KE, Gammon, MD, Santella, RM, Ursin, G, Makalic, E, Schmidt, DF, Casey, G, Hunter, DJ, Gapstur, SM, Gaudet, MM, Diver, WR, Haiman, CA, Schumacher, F, Henderson, BE, Le Marchand, L, Berg, CD, Chanock, SJ, Figueroa, J, Hoover, RN, Lambrechts, D, Neven, P, Wildiers, H, van Limbergen, E, Schmidt, MK, Broeks, A, Verhoef, S, Cornelissen, S, Couch, FJ, Olson, JE, Hallberg, E, Vachon, C, Waisfisz, Q, Meijers-Heijboer, H, Adank, MA, van der Luijt, RB, Li, J, Liu, J, Humphreys, K, Kang, D, Choi, J-Y, Park, SK, Yoo, K-Y, Matsuo, K, Ito, H, Iwata, H, Tajima, K, Guénel, P, Truong, T, Mulot, C, Sanchez, M, Burwinkel, B, Marme, F, Surowy, H, Sohn, C, Wu, AH, Tseng, C, Van Den Berg, D, Stram, DO, González-Neira, A, Benitez, J, Zamora, MP, Perez, JIA, Shu, X-O, Lu, W, Gao, Y-T, Cai, H, Cox, A, Cross, SS, Reed, MWR, Andrulis, IL, Knight, JA, Glendon, G, Mulligan, AM, Sawyer, EJ, Tomlinson, I, Kerin, MJ, Miller, N, Lindblom, A, Margolin, S, Teo, SH, Yip, CH, Taib, NAM, Tan, G-H, Hooning, MJ, Hollestelle, A, Martens, JWM, Collée, JM, Blot, W, Signorello, LB, Cai, Q, Hopper, JL, Southey, MC, Tsimiklis, H, Apicella, C, Shen, C-Y, Hsiung, C-N, Wu, P-E, Hou, M-F, Kristensen, VN, Nord, S, Alnaes, GIG, Giles, GG, Milne, RL, McLean, C, Canzian, F, Trichopoulos, D, Peeters, P, Lund, E, Sund, M, Khaw, K-T, Gunter, MJ, Palli, D, Mortensen, LM, Dossus, L, Huerta, J-M, Meindl, A, Schmutzler, RK, Sutter, C, Yang, R, Muir, K, Lophatananon, A, Stewart-Brown, S, Siriwanarangsan, P, Hartman, M, Miao, H, Chia, KS, Chan, CW, Fasching, PA, Hein, A, Beckmann, MW, Haeberle, L, Brenner, H, Dieffenbach, AK, Arndt, V, Stegmaier, C, Ashworth, A, Orr, N, Schoemaker, MJ, Swerdlow, AJ, Brinton, L, Garcia-Closas, M, Zheng, W, Halverson, SL, Shrubsole, M, Long, J, Goldberg, MS, Labrèche, F, Dumont, M, Winqvist, R, Pylkäs, K, Jukkola-Vuorinen, A, Grip, M, Brauch, H, Hamann, U, Brüning, T, Radice, P, Peterlongo, P, Manoukian, S, Bernard, L, Bogdanova, NV, Dörk, T, Mannermaa, A, Kataja, V, Kosma, V-M, Hartikainen, JM, Devilee, P, Tollenaar, RAEM, Seynaeve, C, Van Asperen, CJ, Jakubowska, A, Lubinski, J, Jaworska, K, Huzarski, T, Sangrajrang, S, Gaborieau, V, Brennan, P, McKay, J, Slager, S, Toland, AE, Ambrosone, CB, Yannoukakos, D, Kabisch, M, Torres, D, Neuhausen, SL, Anton-Culver, H, Luccarini, C, Baynes, C, Ahmed, S, Healey, CS, Tessier, DC, Vincent, D, Bacot, F, Pita, G, Alonso, MR, Álvarez, N, Herrero, D, Simard, J, Pharoah, PPDP, Kraft, P, Dunning, AM, Chenevix-Trench, G, Hall, P, Easton, DF & BOCS 2015, 'Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer', NAT GENET, Jg. 47, Nr. 4, S. 373-80. https://doi.org/10.1038/ng.3242

APA

Michailidou, K., Beesley, J., Lindstrom, S., Canisius, S., Dennis, J., Lush, M. J., Maranian, M. J., Bolla, M. K., Wang, Q., Shah, M., Perkins, B. J., Czene, K., Eriksson, M., Darabi, H., Brand, J. S., Bojesen, S. E., Nordestgaard, B. G., Flyger, H., Nielsen, S. F., ... BOCS (2015). Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer. NAT GENET, 47(4), 373-80. https://doi.org/10.1038/ng.3242

Vancouver

Michailidou K, Beesley J, Lindstrom S, Canisius S, Dennis J, Lush MJ et al. Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer. NAT GENET. 2015 Apr;47(4):373-80. https://doi.org/10.1038/ng.3242

Bibtex

@article{5afa547a766d4a0486302a0c85e1addd,
title = "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer",
abstract = "Genome-wide association studies (GWAS) and large-scale replication studies have identified common variants in 79 loci associated with breast cancer, explaining ∼14% of the familial risk of the disease. To identify new susceptibility loci, we performed a meta-analysis of 11 GWAS, comprising 15,748 breast cancer cases and 18,084 controls together with 46,785 cases and 42,892 controls from 41 studies genotyped on a 211,155-marker custom array (iCOGS). Analyses were restricted to women of European ancestry. We generated genotypes for more than 11 million SNPs by imputation using the 1000 Genomes Project reference panel, and we identified 15 new loci associated with breast cancer at P < 5 × 10(-8). Combining association analysis with ChIP-seq chromatin binding data in mammary cell lines and ChIA-PET chromatin interaction data from ENCODE, we identified likely target genes in two regions: SETBP1 at 18q12.3 and RNF115 and PDZK1 at 1q21.1. One association appears to be driven by an amino acid substitution encoded in EXO1.",
keywords = "Breast Neoplasms, Case-Control Studies, Cohort Studies, Female, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Meta-Analysis as Topic, Microarray Analysis, Polymorphism, Single Nucleotide",
author = "Kyriaki Michailidou and Jonathan Beesley and Sara Lindstrom and Sander Canisius and Joe Dennis and Lush, {Michael J} and Maranian, {Mel J} and Bolla, {Manjeet K} and Qin Wang and Mitul Shah and Perkins, {Barbara J} and Kamila Czene and Mikael Eriksson and Hatef Darabi and Brand, {Judith S} and Bojesen, {Stig E} and Nordestgaard, {B{\o}rge G} and Henrik Flyger and Nielsen, {Sune F} and Nazneen Rahman and Clare Turnbull and Olivia Fletcher and Julian Peto and Lorna Gibson and Isabel dos-Santos-Silva and Jenny Chang-Claude and Dieter Flesch-Janys and Anja Rudolph and Ursula Eilber and Sabine Behrens and Heli Nevanlinna and Muranen, {Taru A} and Kristiina Aittom{\"a}ki and Carl Blomqvist and Sofia Khan and Kirsimari Aaltonen and Habibul Ahsan and Kibriya, {Muhammad G} and Whittemore, {Alice S} and John, {Esther M} and Malone, {Kathleen E} and Gammon, {Marilie D} and Santella, {Regina M} and Giske Ursin and Enes Makalic and Schmidt, {Daniel F} and Graham Casey and Hunter, {David J} and Gapstur, {Susan M} and Gaudet, {Mia M} and Diver, {W Ryan} and Haiman, {Christopher A} and Fredrick Schumacher and Henderson, {Brian E} and {Le Marchand}, Loic and Berg, {Christine D} and Chanock, {Stephen J} and Jonine Figueroa and Hoover, {Robert N} and Diether Lambrechts and Patrick Neven and Hans Wildiers and {van Limbergen}, Erik and Schmidt, {Marjanka K} and Annegien Broeks and Senno Verhoef and Sten Cornelissen and Couch, {Fergus J} and Olson, {Janet E} and Emily Hallberg and Celine Vachon and Quinten Waisfisz and Hanne Meijers-Heijboer and Adank, {Muriel A} and {van der Luijt}, {Rob B} and Jingmei Li and Jianjun Liu and Keith Humphreys and Daehee Kang and Ji-Yeob Choi and Park, {Sue K} and Keun-Young Yoo and Keitaro Matsuo and Hidemi Ito and Hiroji Iwata and Kazuo Tajima and Pascal Gu{\'e}nel and Th{\'e}r{\`e}se Truong and Claire Mulot and Marie Sanchez and Barbara Burwinkel and Frederik Marme and Harald Surowy and Christof Sohn and Wu, {Anna H} and Chiu-chen Tseng and {Van Den Berg}, David and Stram, {Daniel O} and Anna Gonz{\'a}lez-Neira and Javier Benitez and Zamora, {M Pilar} and Perez, {Jose Ignacio Arias} and Xiao-Ou Shu and Wei Lu and Yu-Tang Gao and Hui Cai and Angela Cox and Cross, {Simon S} and Reed, {Malcolm W R} and Andrulis, {Irene L} and Knight, {Julia A} and Gord Glendon and Mulligan, {Anna Marie} and Sawyer, {Elinor J} and Ian Tomlinson and Kerin, {Michael J} and Nicola Miller and Annika Lindblom and Sara Margolin and Teo, {Soo Hwang} and Yip, {Cheng Har} and Taib, {Nur Aishah Mohd} and Gie-Hooi Tan and Hooning, {Maartje J} and Antoinette Hollestelle and Martens, {John W M} and Coll{\'e}e, {J Margriet} and William Blot and Signorello, {Lisa B} and Qiuyin Cai and Hopper, {John L} and Southey, {Melissa C} and Helen Tsimiklis and Carmel Apicella and Chen-Yang Shen and Chia-Ni Hsiung and Pei-Ei Wu and Ming-Feng Hou and Kristensen, {Vessela N} and Silje Nord and Alnaes, {Grethe I Grenaker} and Giles, {Graham G} and Milne, {Roger L} and Catriona McLean and Federico Canzian and Dimitrios Trichopoulos and Petra Peeters and Eiliv Lund and Malin Sund and Kay-Tee Khaw and Gunter, {Marc J} and Domenico Palli and Mortensen, {Lotte Maxild} and Laure Dossus and Jose-Maria Huerta and Alfons Meindl and Schmutzler, {Rita K} and Christian Sutter and Rongxi Yang and Kenneth Muir and Artitaya Lophatananon and Sarah Stewart-Brown and Pornthep Siriwanarangsan and Mikael Hartman and Hui Miao and Chia, {Kee Seng} and Chan, {Ching Wan} and Fasching, {Peter A} and Alexander Hein and Beckmann, {Matthias W} and Lothar Haeberle and Hermann Brenner and Dieffenbach, {Aida Karina} and Volker Arndt and Christa Stegmaier and Alan Ashworth and Nick Orr and Schoemaker, {Minouk J} and Swerdlow, {Anthony J} and Louise Brinton and Montserrat Garcia-Closas and Wei Zheng and Halverson, {Sandra L} and Martha Shrubsole and Jirong Long and Goldberg, {Mark S} and France Labr{\`e}che and Martine Dumont and Robert Winqvist and Katri Pylk{\"a}s and Arja Jukkola-Vuorinen and Mervi Grip and Hiltrud Brauch and Ute Hamann and Thomas Br{\"u}ning and Paolo Radice and Paolo Peterlongo and Siranoush Manoukian and Loris Bernard and Bogdanova, {Natalia V} and Thilo D{\"o}rk and Arto Mannermaa and Vesa Kataja and Veli-Matti Kosma and Hartikainen, {Jaana M} and Peter Devilee and Tollenaar, {Robert A E M} and Caroline Seynaeve and {Van Asperen}, {Christi J} and Anna Jakubowska and Jan Lubinski and Katarzyna Jaworska and Tomasz Huzarski and Suleeporn Sangrajrang and Valerie Gaborieau and Paul Brennan and James McKay and Susan Slager and Toland, {Amanda E} and Ambrosone, {Christine B} and Drakoulis Yannoukakos and Maria Kabisch and Diana Torres and Neuhausen, {Susan L} and Hoda Anton-Culver and Craig Luccarini and Caroline Baynes and Shahana Ahmed and Healey, {Catherine S} and Tessier, {Daniel C} and Daniel Vincent and Francois Bacot and Guillermo Pita and Alonso, {M Rosario} and Nuria {\'A}lvarez and Daniel Herrero and Jacques Simard and Pharoah, {Paul P D P} and Peter Kraft and Dunning, {Alison M} and Georgia Chenevix-Trench and Per Hall and Easton, {Douglas F} and BOCS and Volker Harth",
year = "2015",
month = apr,
doi = "10.1038/ng.3242",
language = "English",
volume = "47",
pages = "373--80",
journal = "NAT GENET",
issn = "1061-4036",
publisher = "NATURE PUBLISHING GROUP",
number = "4",

}

RIS

TY - JOUR

T1 - Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer

AU - Michailidou, Kyriaki

AU - Beesley, Jonathan

AU - Lindstrom, Sara

AU - Canisius, Sander

AU - Dennis, Joe

AU - Lush, Michael J

AU - Maranian, Mel J

AU - Bolla, Manjeet K

AU - Wang, Qin

AU - Shah, Mitul

AU - Perkins, Barbara J

AU - Czene, Kamila

AU - Eriksson, Mikael

AU - Darabi, Hatef

AU - Brand, Judith S

AU - Bojesen, Stig E

AU - Nordestgaard, Børge G

AU - Flyger, Henrik

AU - Nielsen, Sune F

AU - Rahman, Nazneen

AU - Turnbull, Clare

AU - Fletcher, Olivia

AU - Peto, Julian

AU - Gibson, Lorna

AU - dos-Santos-Silva, Isabel

AU - Chang-Claude, Jenny

AU - Flesch-Janys, Dieter

AU - Rudolph, Anja

AU - Eilber, Ursula

AU - Behrens, Sabine

AU - Nevanlinna, Heli

AU - Muranen, Taru A

AU - Aittomäki, Kristiina

AU - Blomqvist, Carl

AU - Khan, Sofia

AU - Aaltonen, Kirsimari

AU - Ahsan, Habibul

AU - Kibriya, Muhammad G

AU - Whittemore, Alice S

AU - John, Esther M

AU - Malone, Kathleen E

AU - Gammon, Marilie D

AU - Santella, Regina M

AU - Ursin, Giske

AU - Makalic, Enes

AU - Schmidt, Daniel F

AU - Casey, Graham

AU - Hunter, David J

AU - Gapstur, Susan M

AU - Gaudet, Mia M

AU - Diver, W Ryan

AU - Haiman, Christopher A

AU - Schumacher, Fredrick

AU - Henderson, Brian E

AU - Le Marchand, Loic

AU - Berg, Christine D

AU - Chanock, Stephen J

AU - Figueroa, Jonine

AU - Hoover, Robert N

AU - Lambrechts, Diether

AU - Neven, Patrick

AU - Wildiers, Hans

AU - van Limbergen, Erik

AU - Schmidt, Marjanka K

AU - Broeks, Annegien

AU - Verhoef, Senno

AU - Cornelissen, Sten

AU - Couch, Fergus J

AU - Olson, Janet E

AU - Hallberg, Emily

AU - Vachon, Celine

AU - Waisfisz, Quinten

AU - Meijers-Heijboer, Hanne

AU - Adank, Muriel A

AU - van der Luijt, Rob B

AU - Li, Jingmei

AU - Liu, Jianjun

AU - Humphreys, Keith

AU - Kang, Daehee

AU - Choi, Ji-Yeob

AU - Park, Sue K

AU - Yoo, Keun-Young

AU - Matsuo, Keitaro

AU - Ito, Hidemi

AU - Iwata, Hiroji

AU - Tajima, Kazuo

AU - Guénel, Pascal

AU - Truong, Thérèse

AU - Mulot, Claire

AU - Sanchez, Marie

AU - Burwinkel, Barbara

AU - Marme, Frederik

AU - Surowy, Harald

AU - Sohn, Christof

AU - Wu, Anna H

AU - Tseng, Chiu-chen

AU - Van Den Berg, David

AU - Stram, Daniel O

AU - González-Neira, Anna

AU - Benitez, Javier

AU - Zamora, M Pilar

AU - Perez, Jose Ignacio Arias

AU - Shu, Xiao-Ou

AU - Lu, Wei

AU - Gao, Yu-Tang

AU - Cai, Hui

AU - Cox, Angela

AU - Cross, Simon S

AU - Reed, Malcolm W R

AU - Andrulis, Irene L

AU - Knight, Julia A

AU - Glendon, Gord

AU - Mulligan, Anna Marie

AU - Sawyer, Elinor J

AU - Tomlinson, Ian

AU - Kerin, Michael J

AU - Miller, Nicola

AU - Lindblom, Annika

AU - Margolin, Sara

AU - Teo, Soo Hwang

AU - Yip, Cheng Har

AU - Taib, Nur Aishah Mohd

AU - Tan, Gie-Hooi

AU - Hooning, Maartje J

AU - Hollestelle, Antoinette

AU - Martens, John W M

AU - Collée, J Margriet

AU - Blot, William

AU - Signorello, Lisa B

AU - Cai, Qiuyin

AU - Hopper, John L

AU - Southey, Melissa C

AU - Tsimiklis, Helen

AU - Apicella, Carmel

AU - Shen, Chen-Yang

AU - Hsiung, Chia-Ni

AU - Wu, Pei-Ei

AU - Hou, Ming-Feng

AU - Kristensen, Vessela N

AU - Nord, Silje

AU - Alnaes, Grethe I Grenaker

AU - Giles, Graham G

AU - Milne, Roger L

AU - McLean, Catriona

AU - Canzian, Federico

AU - Trichopoulos, Dimitrios

AU - Peeters, Petra

AU - Lund, Eiliv

AU - Sund, Malin

AU - Khaw, Kay-Tee

AU - Gunter, Marc J

AU - Palli, Domenico

AU - Mortensen, Lotte Maxild

AU - Dossus, Laure

AU - Huerta, Jose-Maria

AU - Meindl, Alfons

AU - Schmutzler, Rita K

AU - Sutter, Christian

AU - Yang, Rongxi

AU - Muir, Kenneth

AU - Lophatananon, Artitaya

AU - Stewart-Brown, Sarah

AU - Siriwanarangsan, Pornthep

AU - Hartman, Mikael

AU - Miao, Hui

AU - Chia, Kee Seng

AU - Chan, Ching Wan

AU - Fasching, Peter A

AU - Hein, Alexander

AU - Beckmann, Matthias W

AU - Haeberle, Lothar

AU - Brenner, Hermann

AU - Dieffenbach, Aida Karina

AU - Arndt, Volker

AU - Stegmaier, Christa

AU - Ashworth, Alan

AU - Orr, Nick

AU - Schoemaker, Minouk J

AU - Swerdlow, Anthony J

AU - Brinton, Louise

AU - Garcia-Closas, Montserrat

AU - Zheng, Wei

AU - Halverson, Sandra L

AU - Shrubsole, Martha

AU - Long, Jirong

AU - Goldberg, Mark S

AU - Labrèche, France

AU - Dumont, Martine

AU - Winqvist, Robert

AU - Pylkäs, Katri

AU - Jukkola-Vuorinen, Arja

AU - Grip, Mervi

AU - Brauch, Hiltrud

AU - Hamann, Ute

AU - Brüning, Thomas

AU - Radice, Paolo

AU - Peterlongo, Paolo

AU - Manoukian, Siranoush

AU - Bernard, Loris

AU - Bogdanova, Natalia V

AU - Dörk, Thilo

AU - Mannermaa, Arto

AU - Kataja, Vesa

AU - Kosma, Veli-Matti

AU - Hartikainen, Jaana M

AU - Devilee, Peter

AU - Tollenaar, Robert A E M

AU - Seynaeve, Caroline

AU - Van Asperen, Christi J

AU - Jakubowska, Anna

AU - Lubinski, Jan

AU - Jaworska, Katarzyna

AU - Huzarski, Tomasz

AU - Sangrajrang, Suleeporn

AU - Gaborieau, Valerie

AU - Brennan, Paul

AU - McKay, James

AU - Slager, Susan

AU - Toland, Amanda E

AU - Ambrosone, Christine B

AU - Yannoukakos, Drakoulis

AU - Kabisch, Maria

AU - Torres, Diana

AU - Neuhausen, Susan L

AU - Anton-Culver, Hoda

AU - Luccarini, Craig

AU - Baynes, Caroline

AU - Ahmed, Shahana

AU - Healey, Catherine S

AU - Tessier, Daniel C

AU - Vincent, Daniel

AU - Bacot, Francois

AU - Pita, Guillermo

AU - Alonso, M Rosario

AU - Álvarez, Nuria

AU - Herrero, Daniel

AU - Simard, Jacques

AU - Pharoah, Paul P D P

AU - Kraft, Peter

AU - Dunning, Alison M

AU - Chenevix-Trench, Georgia

AU - Hall, Per

AU - Easton, Douglas F

AU - BOCS

AU - Harth, Volker

PY - 2015/4

Y1 - 2015/4

N2 - Genome-wide association studies (GWAS) and large-scale replication studies have identified common variants in 79 loci associated with breast cancer, explaining ∼14% of the familial risk of the disease. To identify new susceptibility loci, we performed a meta-analysis of 11 GWAS, comprising 15,748 breast cancer cases and 18,084 controls together with 46,785 cases and 42,892 controls from 41 studies genotyped on a 211,155-marker custom array (iCOGS). Analyses were restricted to women of European ancestry. We generated genotypes for more than 11 million SNPs by imputation using the 1000 Genomes Project reference panel, and we identified 15 new loci associated with breast cancer at P < 5 × 10(-8). Combining association analysis with ChIP-seq chromatin binding data in mammary cell lines and ChIA-PET chromatin interaction data from ENCODE, we identified likely target genes in two regions: SETBP1 at 18q12.3 and RNF115 and PDZK1 at 1q21.1. One association appears to be driven by an amino acid substitution encoded in EXO1.

AB - Genome-wide association studies (GWAS) and large-scale replication studies have identified common variants in 79 loci associated with breast cancer, explaining ∼14% of the familial risk of the disease. To identify new susceptibility loci, we performed a meta-analysis of 11 GWAS, comprising 15,748 breast cancer cases and 18,084 controls together with 46,785 cases and 42,892 controls from 41 studies genotyped on a 211,155-marker custom array (iCOGS). Analyses were restricted to women of European ancestry. We generated genotypes for more than 11 million SNPs by imputation using the 1000 Genomes Project reference panel, and we identified 15 new loci associated with breast cancer at P < 5 × 10(-8). Combining association analysis with ChIP-seq chromatin binding data in mammary cell lines and ChIA-PET chromatin interaction data from ENCODE, we identified likely target genes in two regions: SETBP1 at 18q12.3 and RNF115 and PDZK1 at 1q21.1. One association appears to be driven by an amino acid substitution encoded in EXO1.

KW - Breast Neoplasms

KW - Case-Control Studies

KW - Cohort Studies

KW - Female

KW - Genetic Loci

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Humans

KW - Meta-Analysis as Topic

KW - Microarray Analysis

KW - Polymorphism, Single Nucleotide

U2 - 10.1038/ng.3242

DO - 10.1038/ng.3242

M3 - SCORING: Journal article

C2 - 25751625

VL - 47

SP - 373

EP - 380

JO - NAT GENET

JF - NAT GENET

SN - 1061-4036

IS - 4

ER -