PortalPublikationenGenome-wide association analysis in primary sclerosing chola...

Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci.

Standard

Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci. / Melum, Espen; Franke, Andre; Schramm, Christoph; Weismüller, Tobias J; Gotthardt, Daniel Nils; Offner, Felix A; Juran, Brian D; Laerdahl, Jon K; Labi, Verena; Björnsson, Einar; Weersma, Rinse K; Henckaerts, Liesbet; Teufel, Andreas; Rust, Christian; Ellinghaus, Eva; Balschun, Tobias; Boberg, Kirsten Muri; Ellinghaus, David; Bergquist, Annika; Sauer, Peter; Ryu, Euijung; Hov, Johannes Roksund; Wedemeyer, Jochen; Lindkvist, Björn; Wittig, Michael; Porte, Robert J; Holm, Kristian; Gieger, Christian; Wichmann, H-Erich; Stokkers, Pieter; Ponsioen, Cyriel Y; Runz, Heiko; Stiehl, Adolf; Wijmenga, Cisca; Sterneck, Martina; Vermeire, Severine; Beuers, Ulrich; Villunger, Andreas; Schrumpf, Erik; Lazaridis, Konstantinos N; Manns, Michael P; Schreiber, Stefan; Karlsen, Tom H.

in: NAT GENET, Jahrgang 43, Nr. 1, 1, 01.2011, S. 17-19.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Melum, E, Franke, A, Schramm, C, Weismüller, TJ, Gotthardt, DN, Offner, FA, Juran, BD, Laerdahl, JK, Labi, V, Björnsson, E, Weersma, RK, Henckaerts, L, Teufel, A, Rust, C, Ellinghaus, E, Balschun, T, Boberg, KM, Ellinghaus, D, Bergquist, A, Sauer, P, Ryu, E, Hov, JR, Wedemeyer, J, Lindkvist, B, Wittig, M, Porte, RJ, Holm, K, Gieger, C, Wichmann, H-E, Stokkers, P, Ponsioen, CY, Runz, H, Stiehl, A, Wijmenga, C, Sterneck, M, Vermeire, S, Beuers, U, Villunger, A, Schrumpf, E, Lazaridis, KN, Manns, MP, Schreiber, S & Karlsen, TH 2011, 'Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci.', NAT GENET, Jg. 43, Nr. 1, 1, S. 17-19. https://doi.org/10.1038/ng.728

APA

Melum, E., Franke, A., Schramm, C., Weismüller, T. J., Gotthardt, D. N., Offner, F. A., Juran, B. D., Laerdahl, J. K., Labi, V., Björnsson, E., Weersma, R. K., Henckaerts, L., Teufel, A., Rust, C., Ellinghaus, E., Balschun, T., Boberg, K. M., Ellinghaus, D., Bergquist, A., ... Karlsen, T. H. (2011). Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci. NAT GENET, 43(1), 17-19. [1]. https://doi.org/10.1038/ng.728

Vancouver

Melum E, Franke A, Schramm C, Weismüller TJ, Gotthardt DN, Offner FA et al. Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci. NAT GENET. 2011 Jan;43(1):17-19. 1. https://doi.org/10.1038/ng.728

Bibtex

@article{8dd6607d392c487ca0de880a12f161db,
title = "Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci.",
abstract = "Primary sclerosing cholangitis (PSC) is a chronic bile duct disease affecting 2.4-7.5% of individuals with inflammatory bowel disease. We performed a genome-wide association analysis of 2,466,182 SNPs in 715 individuals with PSC and 2,962 controls, followed by replication in 1,025 PSC cases and 2,174 controls. We detected non-HLA associations at rs3197999 in MST1 and rs6720394 near BCL2L11 (combined P = 1.1 × 10 ¹ and P = 4.1 × 10 , respectively).",
keywords = "Apoptosis Regulatory Proteins, Bcl-2-Like Protein 11, Cholangitis, Sclerosing, Cohort Studies, Gene Expression Profiling, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, HLA Antigens, Hepatocyte Growth Factor, Humans, Membrane Proteins, Polymorphism, Single Nucleotide, Proto-Oncogene Proteins, Journal Article, Research Support, Non-U.S. Gov't",
author = "Espen Melum and Andre Franke and Christoph Schramm and Weism{\"u}ller, {Tobias J} and Gotthardt, {Daniel Nils} and Offner, {Felix A} and Juran, {Brian D} and Laerdahl, {Jon K} and Verena Labi and Einar Bj{\"o}rnsson and Weersma, {Rinse K} and Liesbet Henckaerts and Andreas Teufel and Christian Rust and Eva Ellinghaus and Tobias Balschun and Boberg, {Kirsten Muri} and David Ellinghaus and Annika Bergquist and Peter Sauer and Euijung Ryu and Hov, {Johannes Roksund} and Jochen Wedemeyer and Bj{\"o}rn Lindkvist and Michael Wittig and Porte, {Robert J} and Kristian Holm and Christian Gieger and H-Erich Wichmann and Pieter Stokkers and Ponsioen, {Cyriel Y} and Heiko Runz and Adolf Stiehl and Cisca Wijmenga and Martina Sterneck and Severine Vermeire and Ulrich Beuers and Andreas Villunger and Erik Schrumpf and Lazaridis, {Konstantinos N} and Manns, {Michael P} and Stefan Schreiber and Karlsen, {Tom H}",
year = "2011",
month = jan,
doi = "10.1038/ng.728",
language = "English",
volume = "43",
pages = "17--19",
journal = "NAT GENET",
issn = "1061-4036",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci.

AU - Melum, Espen

AU - Franke, Andre

AU - Schramm, Christoph

AU - Weismüller, Tobias J

AU - Gotthardt, Daniel Nils

AU - Offner, Felix A

AU - Juran, Brian D

AU - Laerdahl, Jon K

AU - Labi, Verena

AU - Björnsson, Einar

AU - Weersma, Rinse K

AU - Henckaerts, Liesbet

AU - Teufel, Andreas

AU - Rust, Christian

AU - Ellinghaus, Eva

AU - Balschun, Tobias

AU - Boberg, Kirsten Muri

AU - Ellinghaus, David

AU - Bergquist, Annika

AU - Sauer, Peter

AU - Ryu, Euijung

AU - Hov, Johannes Roksund

AU - Wedemeyer, Jochen

AU - Lindkvist, Björn

AU - Wittig, Michael

AU - Porte, Robert J

AU - Holm, Kristian

AU - Gieger, Christian

AU - Wichmann, H-Erich

AU - Stokkers, Pieter

AU - Ponsioen, Cyriel Y

AU - Runz, Heiko

AU - Stiehl, Adolf

AU - Wijmenga, Cisca

AU - Sterneck, Martina

AU - Vermeire, Severine

AU - Beuers, Ulrich

AU - Villunger, Andreas

AU - Schrumpf, Erik

AU - Lazaridis, Konstantinos N

AU - Manns, Michael P

AU - Schreiber, Stefan

AU - Karlsen, Tom H

PY - 2011/1

Y1 - 2011/1

N2 - Primary sclerosing cholangitis (PSC) is a chronic bile duct disease affecting 2.4-7.5% of individuals with inflammatory bowel disease. We performed a genome-wide association analysis of 2,466,182 SNPs in 715 individuals with PSC and 2,962 controls, followed by replication in 1,025 PSC cases and 2,174 controls. We detected non-HLA associations at rs3197999 in MST1 and rs6720394 near BCL2L11 (combined P = 1.1 × 10 ¹ and P = 4.1 × 10 , respectively).

AB - Primary sclerosing cholangitis (PSC) is a chronic bile duct disease affecting 2.4-7.5% of individuals with inflammatory bowel disease. We performed a genome-wide association analysis of 2,466,182 SNPs in 715 individuals with PSC and 2,962 controls, followed by replication in 1,025 PSC cases and 2,174 controls. We detected non-HLA associations at rs3197999 in MST1 and rs6720394 near BCL2L11 (combined P = 1.1 × 10 ¹ and P = 4.1 × 10 , respectively).

KW - Apoptosis Regulatory Proteins

KW - Bcl-2-Like Protein 11

KW - Cholangitis, Sclerosing

KW - Cohort Studies

KW - Gene Expression Profiling

KW - Genetic Loci

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - HLA Antigens

KW - Hepatocyte Growth Factor

KW - Humans

KW - Membrane Proteins

KW - Polymorphism, Single Nucleotide

KW - Proto-Oncogene Proteins

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1038/ng.728

DO - 10.1038/ng.728

M3 - SCORING: Journal article

C2 - 21151127

VL - 43

SP - 17

EP - 19

JO - NAT GENET

JF - NAT GENET

SN - 1061-4036

IS - 1

M1 - 1

ER -