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Genome-Wide Association Analysis for Severity of Coronary Artery Disease Using the Gensini Scoring System

Standard

Genome-Wide Association Analysis for Severity of Coronary Artery Disease Using the Gensini Scoring System. / Zeller, Tanja; Seiffert, Moritz; Müller, Christian; Scholz, Markus; Schäffer, Anna; Ojeda, Francisco; Drexel, Heinz; Mündlein, Axel; Kleber, Marcus E; März, Winfried; Sinning, Christoph; Brunner, Fabian J; Waldeyer, Christoph; Keller, Till; Saely, Christoph H; Sydow, Karsten; Thiery, Joachim; Teupser, Daniel; Blankenberg, Stefan; Schnabel, Renate.

in: FRONT CARDIOVASC MED, Jahrgang 4, 2017, S. 57.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Zeller, T, Seiffert, M, Müller, C, Scholz, M, Schäffer, A, Ojeda, F, Drexel, H, Mündlein, A, Kleber, ME, März, W, Sinning, C, Brunner, FJ, Waldeyer, C, Keller, T, Saely, CH, Sydow, K, Thiery, J, Teupser, D, Blankenberg, S & Schnabel, R 2017, 'Genome-Wide Association Analysis for Severity of Coronary Artery Disease Using the Gensini Scoring System', FRONT CARDIOVASC MED, Jg. 4, S. 57. https://doi.org/10.3389/fcvm.2017.00057

APA

Zeller, T., Seiffert, M., Müller, C., Scholz, M., Schäffer, A., Ojeda, F., Drexel, H., Mündlein, A., Kleber, M. E., März, W., Sinning, C., Brunner, F. J., Waldeyer, C., Keller, T., Saely, C. H., Sydow, K., Thiery, J., Teupser, D., Blankenberg, S., & Schnabel, R. (2017). Genome-Wide Association Analysis for Severity of Coronary Artery Disease Using the Gensini Scoring System. FRONT CARDIOVASC MED, 4, 57. https://doi.org/10.3389/fcvm.2017.00057

Vancouver

Zeller T, Seiffert M, Müller C, Scholz M, Schäffer A, Ojeda F et al. Genome-Wide Association Analysis for Severity of Coronary Artery Disease Using the Gensini Scoring System. FRONT CARDIOVASC MED. 2017;4:57. https://doi.org/10.3389/fcvm.2017.00057

Bibtex

@article{a7813867121f4a289a3b6ab66fb165a4,
title = "Genome-Wide Association Analysis for Severity of Coronary Artery Disease Using the Gensini Scoring System",
abstract = "Coronary artery disease (CAD) has a complex etiology involving numerous environmental and genetic factors of disease risk. To date, the genetic 9p21 locus represents the most robust genetic finding for prevalent and incident CAD. However, limited information is available on the genetic background of the severity and distribution of CAD. CAD manifests itself as stable CAD or acute coronary syndrome. The Gensini score quantifies the extent CAD but requires coronary angiography. Here, we aimed to identify novel genetic variants associated with Gensini score severity and distribution of CAD. A two-stage approach including a discovery and a replication stage was used to assess genetic variants. In the discovery phase, a meta-analysis of genome-wide association data of 4,930 CAD-subjects assessed by the Gensini score was performed. Selected single nucleotide polymorphisms (SNPs) were replicated in 2,283 CAD-subjects by de novo genotyping. We identified genetic loci located on chromosome 2 and 9 to be associated with Gensini score severity and distribution of CAD in the discovery stage. Although the loci on chromosome 2 could not be replicated in the second stage, the known CAD-locus on chromosome 9p21, represented by rs133349, was identified and, thus, was confirmed as risk locus for CAD severity.",
author = "Tanja Zeller and Moritz Seiffert and Christian M{\"u}ller and Markus Scholz and Anna Sch{\"a}ffer and Francisco Ojeda and Heinz Drexel and Axel M{\"u}ndlein and Kleber, {Marcus E} and Winfried M{\"a}rz and Christoph Sinning and Brunner, {Fabian J} and Christoph Waldeyer and Till Keller and Saely, {Christoph H} and Karsten Sydow and Joachim Thiery and Daniel Teupser and Stefan Blankenberg and Renate Schnabel",
year = "2017",
doi = "10.3389/fcvm.2017.00057",
language = "English",
volume = "4",
pages = "57",
journal = "FRONT CARDIOVASC MED",
issn = "2297-055X",
publisher = "Frontiers Media S. A.",

}

RIS

TY - JOUR

T1 - Genome-Wide Association Analysis for Severity of Coronary Artery Disease Using the Gensini Scoring System

AU - Zeller, Tanja

AU - Seiffert, Moritz

AU - Müller, Christian

AU - Scholz, Markus

AU - Schäffer, Anna

AU - Ojeda, Francisco

AU - Drexel, Heinz

AU - Mündlein, Axel

AU - Kleber, Marcus E

AU - März, Winfried

AU - Sinning, Christoph

AU - Brunner, Fabian J

AU - Waldeyer, Christoph

AU - Keller, Till

AU - Saely, Christoph H

AU - Sydow, Karsten

AU - Thiery, Joachim

AU - Teupser, Daniel

AU - Blankenberg, Stefan

AU - Schnabel, Renate

PY - 2017

Y1 - 2017

N2 - Coronary artery disease (CAD) has a complex etiology involving numerous environmental and genetic factors of disease risk. To date, the genetic 9p21 locus represents the most robust genetic finding for prevalent and incident CAD. However, limited information is available on the genetic background of the severity and distribution of CAD. CAD manifests itself as stable CAD or acute coronary syndrome. The Gensini score quantifies the extent CAD but requires coronary angiography. Here, we aimed to identify novel genetic variants associated with Gensini score severity and distribution of CAD. A two-stage approach including a discovery and a replication stage was used to assess genetic variants. In the discovery phase, a meta-analysis of genome-wide association data of 4,930 CAD-subjects assessed by the Gensini score was performed. Selected single nucleotide polymorphisms (SNPs) were replicated in 2,283 CAD-subjects by de novo genotyping. We identified genetic loci located on chromosome 2 and 9 to be associated with Gensini score severity and distribution of CAD in the discovery stage. Although the loci on chromosome 2 could not be replicated in the second stage, the known CAD-locus on chromosome 9p21, represented by rs133349, was identified and, thus, was confirmed as risk locus for CAD severity.

AB - Coronary artery disease (CAD) has a complex etiology involving numerous environmental and genetic factors of disease risk. To date, the genetic 9p21 locus represents the most robust genetic finding for prevalent and incident CAD. However, limited information is available on the genetic background of the severity and distribution of CAD. CAD manifests itself as stable CAD or acute coronary syndrome. The Gensini score quantifies the extent CAD but requires coronary angiography. Here, we aimed to identify novel genetic variants associated with Gensini score severity and distribution of CAD. A two-stage approach including a discovery and a replication stage was used to assess genetic variants. In the discovery phase, a meta-analysis of genome-wide association data of 4,930 CAD-subjects assessed by the Gensini score was performed. Selected single nucleotide polymorphisms (SNPs) were replicated in 2,283 CAD-subjects by de novo genotyping. We identified genetic loci located on chromosome 2 and 9 to be associated with Gensini score severity and distribution of CAD in the discovery stage. Although the loci on chromosome 2 could not be replicated in the second stage, the known CAD-locus on chromosome 9p21, represented by rs133349, was identified and, thus, was confirmed as risk locus for CAD severity.

U2 - 10.3389/fcvm.2017.00057

DO - 10.3389/fcvm.2017.00057

M3 - SCORING: Journal article

C2 - 28979897

VL - 4

SP - 57

JO - FRONT CARDIOVASC MED

JF - FRONT CARDIOVASC MED

SN - 2297-055X

ER -