PortalPublikationenGenetic variation at chromosome 1p13.3 affects sortilin mRNA...

Genetic variation at chromosome 1p13.3 affects sortilin mRNA expression, cellular LDL-uptake and serum LDL levels which translates to the risk of coronary artery disease.

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  • Patrick Linsel-Nitschke
  • Jörg Heeren
  • Zouhair Aherrahrou
  • Petra Bruse
  • Christian Gieger
  • Thomas Illig
  • Holger Prokisch
  • Katharina Heim
  • Angela Doering
  • Annette Peters
  • Thomas Meitinger
  • H-Erich Wichmann
  • Anke Hinney
  • Thomas Reinehr
  • Christian Roth
  • Jan R Ortlepp
  • Mouhidien Soufi
  • Alexander M Sattler
  • Jürgen Schaefer
  • Klaus Stark
  • Christian Hengstenberg
  • Arne Schaefer
  • Stefan Schreiber
  • Florian Kronenberg
  • Nilesh J Samani
  • Heribert Schunkert
  • Jeanette Erdmann

Beteiligte Einrichtungen

Abstract

A single nucleotide polymorphism (SNP) rs599839 located at chromosome 1p13.3 has previously been associated with risk of coronary artery disease (CAD) and with serum levels of low-density lipoprotein cholesterol (LDL-C). A functional link explaining the association of SNP rs599839 with LDL-C levels and CAD risk has not yet been elucidated.

Bibliografische Daten

OriginalspracheDeutsch
Aufsatznummer1
ISSN0021-9150
StatusVeröffentlicht - 2010
pubmed 19660754