Genetic variants implicated in telomere length associated with left ventricular function in patients with hypertension and cardiac organ damage.
Standard
Genetic variants implicated in telomere length associated with left ventricular function in patients with hypertension and cardiac organ damage. / Huber, Matthias; Treszl, András; Wehland, Markus; Winther, Ingke; Zergibel, Irina; Reibis, Rona; Bolbrinker, Juliane; Stoll, Monika; Schönfelder, Gilbert; Wegscheider, Karl; Völler, Heinz; Kreutz, Reinhold.
in: J MOL MED, Jahrgang 90, Nr. 9, 9, 2012, S. 1059-1067.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Genetic variants implicated in telomere length associated with left ventricular function in patients with hypertension and cardiac organ damage.
AU - Huber, Matthias
AU - Treszl, András
AU - Wehland, Markus
AU - Winther, Ingke
AU - Zergibel, Irina
AU - Reibis, Rona
AU - Bolbrinker, Juliane
AU - Stoll, Monika
AU - Schönfelder, Gilbert
AU - Wegscheider, Karl
AU - Völler, Heinz
AU - Kreutz, Reinhold
PY - 2012
Y1 - 2012
N2 - Telomere length has emerged as a biological correlate for ageing, which in turn is a risk factor for the manifestation of cardiovascular diseases. This study investigated the relation between leucocyte telomere length (LTL) and its genetic background to cardiac structure and function in patients with arterial hypertension. We analysed a cohort of 1,106 treated hypertensive patients (83.3% males; mean age, 57.9?±?9.8 years) with an ejection fraction (EF) over 40% and documented cardiovascular disease or target organ damage. LTL and genotypes of single nucleotide polymorphisms (SNPs), previously implicated in LTL, were determined by real-time PCR. The mean left ventricular mass index (LVMI) and EF were 51.8? ±? 21.0 g/H2.7 and 61.1 ?±? 9.6%, respectively. In multivariate adjusted analysis, a 1.5-fold LTL was positively related with a 2.2% increase of LVMI (CI?=?0.1% to 4.2%, p?=?0.044) and an absolute increase in EF of 0.6% (CI?=?0.1% to 1.1%, p?=?0.028). One SNP near TERC (rs16847897) showed a significant absolute difference in EF dependent on allele status (rs16847897, G allele 2.7%; CI?=?0.7% to 4.6%; p raw?=?0.008, p mt?=?0.048, after adjustment for multiple testing). This applied also for two SNPs in BICD1 (rs2630578, C allele ?1.8%; CI?=??2.8% to ?0.7%; p raw?=?0.002, p mt?=?0.018; rs1151026, G allele ?1.9%, CI?=??3.0% to ?0.8%; p raw?<?0.001, p mt?=?0.002) with the extension that a frequent haplotype in BICD1 showed an absolute ?1.8% (CI?=??3.0% to ?0.7%; p raw?=?0.002, p mt?=?0.008) lower EF compared with those lacking this haplotype. Our results point to a role of genetic variants recently implicated in LTL for left ventricular function in hypertensive patients.
AB - Telomere length has emerged as a biological correlate for ageing, which in turn is a risk factor for the manifestation of cardiovascular diseases. This study investigated the relation between leucocyte telomere length (LTL) and its genetic background to cardiac structure and function in patients with arterial hypertension. We analysed a cohort of 1,106 treated hypertensive patients (83.3% males; mean age, 57.9?±?9.8 years) with an ejection fraction (EF) over 40% and documented cardiovascular disease or target organ damage. LTL and genotypes of single nucleotide polymorphisms (SNPs), previously implicated in LTL, were determined by real-time PCR. The mean left ventricular mass index (LVMI) and EF were 51.8? ±? 21.0 g/H2.7 and 61.1 ?±? 9.6%, respectively. In multivariate adjusted analysis, a 1.5-fold LTL was positively related with a 2.2% increase of LVMI (CI?=?0.1% to 4.2%, p?=?0.044) and an absolute increase in EF of 0.6% (CI?=?0.1% to 1.1%, p?=?0.028). One SNP near TERC (rs16847897) showed a significant absolute difference in EF dependent on allele status (rs16847897, G allele 2.7%; CI?=?0.7% to 4.6%; p raw?=?0.008, p mt?=?0.048, after adjustment for multiple testing). This applied also for two SNPs in BICD1 (rs2630578, C allele ?1.8%; CI?=??2.8% to ?0.7%; p raw?=?0.002, p mt?=?0.018; rs1151026, G allele ?1.9%, CI?=??3.0% to ?0.8%; p raw?<?0.001, p mt?=?0.002) with the extension that a frequent haplotype in BICD1 showed an absolute ?1.8% (CI?=??3.0% to ?0.7%; p raw?=?0.002, p mt?=?0.008) lower EF compared with those lacking this haplotype. Our results point to a role of genetic variants recently implicated in LTL for left ventricular function in hypertensive patients.
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Cohort Studies
KW - Genotype
KW - Polymorphism, Single Nucleotide
KW - Alleles
KW - Aging
KW - Echocardiography
KW - Ventricular Function, Left
KW - Real-Time Polymerase Chain Reaction
KW - Adaptor Proteins, Signal Transducing/genetics
KW - Cardiovascular Diseases/complications/genetics/pathology/physiopathology
KW - Cytoskeletal Proteins/genetics
KW - Heart Ventricles/pathology/physiopathology
KW - Hypertension/complications/genetics
KW - Leukocytes/metabolism/pathology
KW - Telomere/genetics/pathology
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Cohort Studies
KW - Genotype
KW - Polymorphism, Single Nucleotide
KW - Alleles
KW - Aging
KW - Echocardiography
KW - Ventricular Function, Left
KW - Real-Time Polymerase Chain Reaction
KW - Adaptor Proteins, Signal Transducing/genetics
KW - Cardiovascular Diseases/complications/genetics/pathology/physiopathology
KW - Cytoskeletal Proteins/genetics
KW - Heart Ventricles/pathology/physiopathology
KW - Hypertension/complications/genetics
KW - Leukocytes/metabolism/pathology
KW - Telomere/genetics/pathology
M3 - SCORING: Journal article
VL - 90
SP - 1059
EP - 1067
JO - J MOL MED
JF - J MOL MED
SN - 0946-2716
IS - 9
M1 - 9
ER -
