Generic acquisition protocol for quantitative MRI of the spinal cord

TY - JOUR

T1 - Generic acquisition protocol for quantitative MRI of the spinal cord

AU - Cohen-Adad, Julien

AU - Alonso-Ortiz, Eva

AU - Abramovic, Mihael

AU - Arneitz, Carina

AU - Atcheson, Nicole

AU - Barlow, Laura

AU - Barry, Robert L

AU - Barth, Markus

AU - Battiston, Marco

AU - Büchel, Christian

AU - Budde, Matthew

AU - Callot, Virginie

AU - Combes, Anna J E

AU - De Leener, Benjamin

AU - Descoteaux, Maxime

AU - de Sousa, Paulo Loureiro

AU - Dostál, Marek

AU - Doyon, Julien

AU - Dvorak, Adam

AU - Eippert, Falk

AU - Epperson, Karla R

AU - Epperson, Kevin S

AU - Freund, Patrick

AU - Finsterbusch, Jürgen

AU - Foias, Alexandru

AU - Fratini, Michela

AU - Fukunaga, Issei

AU - Wheeler-Kingshott, Claudia A M Gandini

AU - Germani, Giancarlo

AU - Gilbert, Guillaume

AU - Giove, Federico

AU - Gros, Charley

AU - Grussu, Francesco

AU - Hagiwara, Akifumi

AU - Henry, Pierre-Gilles

AU - Horák, Tomáš

AU - Hori, Masaaki

AU - Joers, James

AU - Kamiya, Kouhei

AU - Karbasforoushan, Haleh

AU - Keřkovský, Miloš

AU - Khatibi, Ali

AU - Kim, Joo-Won

AU - Kinany, Nawal

AU - Kitzler, Hagen

AU - Kolind, Shannon

AU - Kong, Yazhuo

AU - Kudlička, Petr

AU - Kuntke, Paul

AU - Kurniawan, Nyoman D

AU - Kusmia, Slawomir

AU - Labounek, René

AU - Laganà, Maria Marcella

AU - Laule, Cornelia

AU - Law, Christine S

AU - Lenglet, Christophe

AU - Leutritz, Tobias

AU - Liu, Yaou

AU - Llufriu, Sara

AU - Mackey, Sean

AU - Martinez-Heras, Eloy

AU - Mattera, Loan

AU - Nestrasil, Igor

AU - O'Grady, Kristin P

AU - Papinutto, Nico

AU - Papp, Daniel

AU - Pareto, Deborah

AU - Parrish, Todd B

AU - Pichiecchio, Anna

AU - Prados, Ferran

AU - Rovira, Àlex

AU - Ruitenberg, Marc J

AU - Samson, Rebecca S

AU - Savini, Giovanni

AU - Seif, Maryam

AU - Seifert, Alan C

AU - Smith, Alex K

AU - Smith, Seth A

AU - Smith, Zachary A

AU - Solana, Elisabeth

AU - Suzuki, Yuichi

AU - Tackley, George

AU - Tinnermann, Alexandra

AU - Valošek, Jan

AU - Van De Ville, Dimitri

AU - Yiannakas, Marios C

AU - Weber, Kenneth A

AU - Weiskopf, Nikolaus

AU - Wise, Richard G

AU - Wyss, Patrik O

AU - Xu, Junqian

N1 - © 2021. The Author(s), under exclusive licence to Springer Nature Limited.

PY - 2021/10

Y1 - 2021/10

N2 - Quantitative spinal cord (SC) magnetic resonance imaging (MRI) presents many challenges, including a lack of standardized imaging protocols. Here we present a prospectively harmonized quantitative MRI protocol, which we refer to as the spine generic protocol, for users of 3T MRI systems from the three main manufacturers: GE, Philips and Siemens. The protocol provides guidance for assessing SC macrostructural and microstructural integrity: T1-weighted and T2-weighted imaging for SC cross-sectional area computation, multi-echo gradient echo for gray matter cross-sectional area, and magnetization transfer and diffusion weighted imaging for assessing white matter microstructure. In a companion paper from the same authors, the spine generic protocol was used to acquire data across 42 centers in 260 healthy subjects. The key details of the spine generic protocol are also available in an open-access document that can be found at https://github.com/spine-generic/protocols . The protocol will serve as a starting point for researchers and clinicians implementing new SC imaging initiatives so that, in the future, inclusion of the SC in neuroimaging protocols will be more common. The protocol could be implemented by any trained MR technician or by a researcher/clinician familiar with MRI acquisition.

AB - Quantitative spinal cord (SC) magnetic resonance imaging (MRI) presents many challenges, including a lack of standardized imaging protocols. Here we present a prospectively harmonized quantitative MRI protocol, which we refer to as the spine generic protocol, for users of 3T MRI systems from the three main manufacturers: GE, Philips and Siemens. The protocol provides guidance for assessing SC macrostructural and microstructural integrity: T1-weighted and T2-weighted imaging for SC cross-sectional area computation, multi-echo gradient echo for gray matter cross-sectional area, and magnetization transfer and diffusion weighted imaging for assessing white matter microstructure. In a companion paper from the same authors, the spine generic protocol was used to acquire data across 42 centers in 260 healthy subjects. The key details of the spine generic protocol are also available in an open-access document that can be found at https://github.com/spine-generic/protocols . The protocol will serve as a starting point for researchers and clinicians implementing new SC imaging initiatives so that, in the future, inclusion of the SC in neuroimaging protocols will be more common. The protocol could be implemented by any trained MR technician or by a researcher/clinician familiar with MRI acquisition.

KW - Adult

KW - Humans

KW - Image Processing, Computer-Assisted

KW - Magnetic Resonance Imaging

KW - Male

KW - Neuroimaging

KW - Spinal Cord

U2 - 10.1038/s41596-021-00588-0

DO - 10.1038/s41596-021-00588-0

M3 - SCORING: Journal article

C2 - 34400839

VL - 16

SP - 4611

EP - 4632

JO - NAT PROTOC

JF - NAT PROTOC

SN - 1754-2189

IS - 10

ER -