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Gene-environment interaction and risk of breast cancer

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Gene-environment interaction and risk of breast cancer. / Rudolph, Anja; Chang-Claude, Jenny; Schmidt, Marjanka K.

in: BRIT J CANCER, Jahrgang 114, Nr. 2, 19.01.2016, S. 125-33.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Rudolph, A, Chang-Claude, J & Schmidt, MK 2016, 'Gene-environment interaction and risk of breast cancer', BRIT J CANCER, Jg. 114, Nr. 2, S. 125-33. https://doi.org/10.1038/bjc.2015.439

APA

Rudolph, A., Chang-Claude, J., & Schmidt, M. K. (2016). Gene-environment interaction and risk of breast cancer. BRIT J CANCER, 114(2), 125-33. https://doi.org/10.1038/bjc.2015.439

Vancouver

Rudolph A, Chang-Claude J, Schmidt MK. Gene-environment interaction and risk of breast cancer. BRIT J CANCER. 2016 Jan 19;114(2):125-33. https://doi.org/10.1038/bjc.2015.439

Bibtex

@article{9436d9b4bce3486787816361bb78abd3,
title = "Gene-environment interaction and risk of breast cancer",
abstract = "Hereditary, genetic factors as well as lifestyle and environmental factors, for example, parity and body mass index, predict breast cancer development. Gene-environment interaction studies may help to identify subgroups of women at high-risk of breast cancer and can be leveraged to discover new genetic risk factors. A few interesting results in studies including over 30 000 breast cancer cases and healthy controls indicate that such interactions exist. Explorative gene-environment interaction studies aiming to identify new genetic or environmental factors are scarce and still underpowered. Gene-environment interactions might be stronger for rare genetic variants, but data are lacking. Ongoing initiatives to genotype larger sample sets in combination with comprehensive epidemiologic databases will provide further opportunities to study gene-environment interactions in breast cancer. However, based on the available evidence, we conclude that associations between the common genetic variants known today and breast cancer risk are only weakly modified by environmental factors, if at all.",
author = "Anja Rudolph and Jenny Chang-Claude and Schmidt, {Marjanka K}",
year = "2016",
month = jan,
day = "19",
doi = "10.1038/bjc.2015.439",
language = "English",
volume = "114",
pages = "125--33",
journal = "BRIT J CANCER",
issn = "0007-0920",
publisher = "NATURE PUBLISHING GROUP",
number = "2",

}

RIS

TY - JOUR

T1 - Gene-environment interaction and risk of breast cancer

AU - Rudolph, Anja

AU - Chang-Claude, Jenny

AU - Schmidt, Marjanka K

PY - 2016/1/19

Y1 - 2016/1/19

N2 - Hereditary, genetic factors as well as lifestyle and environmental factors, for example, parity and body mass index, predict breast cancer development. Gene-environment interaction studies may help to identify subgroups of women at high-risk of breast cancer and can be leveraged to discover new genetic risk factors. A few interesting results in studies including over 30 000 breast cancer cases and healthy controls indicate that such interactions exist. Explorative gene-environment interaction studies aiming to identify new genetic or environmental factors are scarce and still underpowered. Gene-environment interactions might be stronger for rare genetic variants, but data are lacking. Ongoing initiatives to genotype larger sample sets in combination with comprehensive epidemiologic databases will provide further opportunities to study gene-environment interactions in breast cancer. However, based on the available evidence, we conclude that associations between the common genetic variants known today and breast cancer risk are only weakly modified by environmental factors, if at all.

AB - Hereditary, genetic factors as well as lifestyle and environmental factors, for example, parity and body mass index, predict breast cancer development. Gene-environment interaction studies may help to identify subgroups of women at high-risk of breast cancer and can be leveraged to discover new genetic risk factors. A few interesting results in studies including over 30 000 breast cancer cases and healthy controls indicate that such interactions exist. Explorative gene-environment interaction studies aiming to identify new genetic or environmental factors are scarce and still underpowered. Gene-environment interactions might be stronger for rare genetic variants, but data are lacking. Ongoing initiatives to genotype larger sample sets in combination with comprehensive epidemiologic databases will provide further opportunities to study gene-environment interactions in breast cancer. However, based on the available evidence, we conclude that associations between the common genetic variants known today and breast cancer risk are only weakly modified by environmental factors, if at all.

U2 - 10.1038/bjc.2015.439

DO - 10.1038/bjc.2015.439

M3 - SCORING: Journal article

C2 - 26757262

VL - 114

SP - 125

EP - 133

JO - BRIT J CANCER

JF - BRIT J CANCER

SN - 0007-0920

IS - 2

ER -