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Gene expression profiling of circulating natural killer cells in head and neck squamous cell carcinoma

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Gene expression profiling of circulating natural killer cells in head and neck squamous cell carcinoma. / Böttcher, Arne; Ostwald, Jürgen; Koczan, Dirk; Knecht, Rainald; Kramp, Burkhard; Dommerich, Steffen.

in: CANCER GENOM PROTEOM, Jahrgang 10, Nr. 5, 2013, S. 197-207.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Böttcher, A, Ostwald, J, Koczan, D, Knecht, R, Kramp, B & Dommerich, S 2013, 'Gene expression profiling of circulating natural killer cells in head and neck squamous cell carcinoma', CANCER GENOM PROTEOM, Jg. 10, Nr. 5, S. 197-207.

APA

Böttcher, A., Ostwald, J., Koczan, D., Knecht, R., Kramp, B., & Dommerich, S. (2013). Gene expression profiling of circulating natural killer cells in head and neck squamous cell carcinoma. CANCER GENOM PROTEOM, 10(5), 197-207.

Vancouver

Böttcher A, Ostwald J, Koczan D, Knecht R, Kramp B, Dommerich S. Gene expression profiling of circulating natural killer cells in head and neck squamous cell carcinoma. CANCER GENOM PROTEOM. 2013;10(5):197-207.

Bibtex

@article{7febc80132054778968af10592be195b,
title = "Gene expression profiling of circulating natural killer cells in head and neck squamous cell carcinoma",
abstract = "BACKGROUND: Natural killer (NK) cells are a major player of the innate immune system. Besides known risk factors for head and neck squamous cell carcinoma (HNSCC), impaired immune surveillance may as well lead to tumor manifestation.MATERIALS AND METHODS: In the present study, microarrays technologies were employed in order to perform gene expression profiling of NK cells in HNSCC patients. Differentially expressed genes have been detected in a comparative setting consisting of non-treated HNSCC patients, treated recurrence-free HNSCC patients and healthy control subjects.RESULTS: Cytokine receptors such as CCR7, IL-7R, and CXCR3 were down-regulated in non-treated HNSCC patients compared to healthy subjects, indicating impaired immune surveillance. In treated patients, up-regulated genes such as receptors for Fc fragments of specific antibodies, or ficolin-1 can be withheld as an immunological response to tumor manifestation.CONCLUSION: This study provides insights into gene expression changes in NK cells of HNSCC dependent upon clinical status and introduces several candidate genes suitable for further investigation.",
keywords = "Adolescent, Adult, Aged, Carcinoma, Squamous Cell, Case-Control Studies, Cell Line, Tumor, Cohort Studies, Female, Gene Expression Profiling, Head and Neck Neoplasms, Humans, Killer Cells, Natural, Male, Middle Aged, Risk Factors",
author = "Arne B{\"o}ttcher and J{\"u}rgen Ostwald and Dirk Koczan and Rainald Knecht and Burkhard Kramp and Steffen Dommerich",
year = "2013",
language = "English",
volume = "10",
pages = "197--207",
journal = "CANCER GENOM PROTEOM",
issn = "1109-6535",
publisher = "International Institute of Anticancer Research",
number = "5",

}

RIS

TY - JOUR

T1 - Gene expression profiling of circulating natural killer cells in head and neck squamous cell carcinoma

AU - Böttcher, Arne

AU - Ostwald, Jürgen

AU - Koczan, Dirk

AU - Knecht, Rainald

AU - Kramp, Burkhard

AU - Dommerich, Steffen

PY - 2013

Y1 - 2013

N2 - BACKGROUND: Natural killer (NK) cells are a major player of the innate immune system. Besides known risk factors for head and neck squamous cell carcinoma (HNSCC), impaired immune surveillance may as well lead to tumor manifestation.MATERIALS AND METHODS: In the present study, microarrays technologies were employed in order to perform gene expression profiling of NK cells in HNSCC patients. Differentially expressed genes have been detected in a comparative setting consisting of non-treated HNSCC patients, treated recurrence-free HNSCC patients and healthy control subjects.RESULTS: Cytokine receptors such as CCR7, IL-7R, and CXCR3 were down-regulated in non-treated HNSCC patients compared to healthy subjects, indicating impaired immune surveillance. In treated patients, up-regulated genes such as receptors for Fc fragments of specific antibodies, or ficolin-1 can be withheld as an immunological response to tumor manifestation.CONCLUSION: This study provides insights into gene expression changes in NK cells of HNSCC dependent upon clinical status and introduces several candidate genes suitable for further investigation.

AB - BACKGROUND: Natural killer (NK) cells are a major player of the innate immune system. Besides known risk factors for head and neck squamous cell carcinoma (HNSCC), impaired immune surveillance may as well lead to tumor manifestation.MATERIALS AND METHODS: In the present study, microarrays technologies were employed in order to perform gene expression profiling of NK cells in HNSCC patients. Differentially expressed genes have been detected in a comparative setting consisting of non-treated HNSCC patients, treated recurrence-free HNSCC patients and healthy control subjects.RESULTS: Cytokine receptors such as CCR7, IL-7R, and CXCR3 were down-regulated in non-treated HNSCC patients compared to healthy subjects, indicating impaired immune surveillance. In treated patients, up-regulated genes such as receptors for Fc fragments of specific antibodies, or ficolin-1 can be withheld as an immunological response to tumor manifestation.CONCLUSION: This study provides insights into gene expression changes in NK cells of HNSCC dependent upon clinical status and introduces several candidate genes suitable for further investigation.

KW - Adolescent

KW - Adult

KW - Aged

KW - Carcinoma, Squamous Cell

KW - Case-Control Studies

KW - Cell Line, Tumor

KW - Cohort Studies

KW - Female

KW - Gene Expression Profiling

KW - Head and Neck Neoplasms

KW - Humans

KW - Killer Cells, Natural

KW - Male

KW - Middle Aged

KW - Risk Factors

M3 - SCORING: Journal article

C2 - 24136972

VL - 10

SP - 197

EP - 207

JO - CANCER GENOM PROTEOM

JF - CANCER GENOM PROTEOM

SN - 1109-6535

IS - 5

ER -