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Gene expression of cytokines, growth factors and apoptosis regulators in a neonatal model of pulmonary stenosis

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Gene expression of cytokines, growth factors and apoptosis regulators in a neonatal model of pulmonary stenosis. / Liersch, Peter N; Schwarz, Andreas; Sachweh, Joerg; Hermanns-Sachweh, Benita; Heying, Ruth; Vázquez-Jimènez, Jaime F; Albert, Adelin; Seghaye, Marie-Christine.

in: FUTUR CARDIOL, Jahrgang 11, Nr. 3, 05.2015, S. 297-307.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Liersch, PN, Schwarz, A, Sachweh, J, Hermanns-Sachweh, B, Heying, R, Vázquez-Jimènez, JF, Albert, A & Seghaye, M-C 2015, 'Gene expression of cytokines, growth factors and apoptosis regulators in a neonatal model of pulmonary stenosis', FUTUR CARDIOL, Jg. 11, Nr. 3, S. 297-307. https://doi.org/10.2217/fca.15.25

APA

Liersch, P. N., Schwarz, A., Sachweh, J., Hermanns-Sachweh, B., Heying, R., Vázquez-Jimènez, J. F., Albert, A., & Seghaye, M-C. (2015). Gene expression of cytokines, growth factors and apoptosis regulators in a neonatal model of pulmonary stenosis. FUTUR CARDIOL, 11(3), 297-307. https://doi.org/10.2217/fca.15.25

Vancouver

Liersch PN, Schwarz A, Sachweh J, Hermanns-Sachweh B, Heying R, Vázquez-Jimènez JF et al. Gene expression of cytokines, growth factors and apoptosis regulators in a neonatal model of pulmonary stenosis. FUTUR CARDIOL. 2015 Mai;11(3):297-307. https://doi.org/10.2217/fca.15.25

Bibtex

@article{3a8b679d7ebd4ed08e5c6ddaa0ff8daa,
title = "Gene expression of cytokines, growth factors and apoptosis regulators in a neonatal model of pulmonary stenosis",
abstract = "BACKGROUND: Right ventricular remodeling due to pulmonary stenosis increases morbidity in children. Its pathophysiology needs to be clarified.METHODS: Six newborn lambs underwent pulmonary arterial banding, seven sham operation. mRNA encoding for cytokines, growth factors and regulators of apoptosis was sequentially measured in myocardium and blood before and up to 12 weeks postoperatively.RESULTS: Experimental animals showed hypertrophy and fibrosis of the right ventricular myocardium, myocardial over-expression of CT-1-mRNA and higher blood concentrations of mRNA encoding for VEGF, TGF-β, Bak and BcL-xL than controls, respectively.CONCLUSION: Neonatal pulmonary stenosis leads to myocardial hypertrophy that is associated with CT-1 gene expression and with activation of growth- and apoptosis pathways in blood cells.",
keywords = "Animals, Animals, Newborn, Apoptosis/genetics, Cytokines/biosynthesis, DNA/genetics, Disease Models, Animal, Gene Expression Regulation, Developmental, Intercellular Signaling Peptides and Proteins/biosynthesis, Microscopy, Electron, Myocardium/metabolism, Pulmonary Valve Stenosis/genetics, Real-Time Polymerase Chain Reaction, Sheep",
author = "Liersch, {Peter N} and Andreas Schwarz and Joerg Sachweh and Benita Hermanns-Sachweh and Ruth Heying and V{\'a}zquez-Jim{\`e}nez, {Jaime F} and Adelin Albert and Marie-Christine Seghaye",
year = "2015",
month = may,
doi = "10.2217/fca.15.25",
language = "English",
volume = "11",
pages = "297--307",
journal = "FUTUR CARDIOL",
issn = "1479-6678",
publisher = "Future Medicine Ltd",
number = "3",

}

RIS

TY - JOUR

T1 - Gene expression of cytokines, growth factors and apoptosis regulators in a neonatal model of pulmonary stenosis

AU - Liersch, Peter N

AU - Schwarz, Andreas

AU - Sachweh, Joerg

AU - Hermanns-Sachweh, Benita

AU - Heying, Ruth

AU - Vázquez-Jimènez, Jaime F

AU - Albert, Adelin

AU - Seghaye, Marie-Christine

PY - 2015/5

Y1 - 2015/5

N2 - BACKGROUND: Right ventricular remodeling due to pulmonary stenosis increases morbidity in children. Its pathophysiology needs to be clarified.METHODS: Six newborn lambs underwent pulmonary arterial banding, seven sham operation. mRNA encoding for cytokines, growth factors and regulators of apoptosis was sequentially measured in myocardium and blood before and up to 12 weeks postoperatively.RESULTS: Experimental animals showed hypertrophy and fibrosis of the right ventricular myocardium, myocardial over-expression of CT-1-mRNA and higher blood concentrations of mRNA encoding for VEGF, TGF-β, Bak and BcL-xL than controls, respectively.CONCLUSION: Neonatal pulmonary stenosis leads to myocardial hypertrophy that is associated with CT-1 gene expression and with activation of growth- and apoptosis pathways in blood cells.

AB - BACKGROUND: Right ventricular remodeling due to pulmonary stenosis increases morbidity in children. Its pathophysiology needs to be clarified.METHODS: Six newborn lambs underwent pulmonary arterial banding, seven sham operation. mRNA encoding for cytokines, growth factors and regulators of apoptosis was sequentially measured in myocardium and blood before and up to 12 weeks postoperatively.RESULTS: Experimental animals showed hypertrophy and fibrosis of the right ventricular myocardium, myocardial over-expression of CT-1-mRNA and higher blood concentrations of mRNA encoding for VEGF, TGF-β, Bak and BcL-xL than controls, respectively.CONCLUSION: Neonatal pulmonary stenosis leads to myocardial hypertrophy that is associated with CT-1 gene expression and with activation of growth- and apoptosis pathways in blood cells.

KW - Animals

KW - Animals, Newborn

KW - Apoptosis/genetics

KW - Cytokines/biosynthesis

KW - DNA/genetics

KW - Disease Models, Animal

KW - Gene Expression Regulation, Developmental

KW - Intercellular Signaling Peptides and Proteins/biosynthesis

KW - Microscopy, Electron

KW - Myocardium/metabolism

KW - Pulmonary Valve Stenosis/genetics

KW - Real-Time Polymerase Chain Reaction

KW - Sheep

U2 - 10.2217/fca.15.25

DO - 10.2217/fca.15.25

M3 - SCORING: Journal article

C2 - 26021636

VL - 11

SP - 297

EP - 307

JO - FUTUR CARDIOL

JF - FUTUR CARDIOL

SN - 1479-6678

IS - 3

ER -