PortalPublikationenGene expression analysis identifies potential biomarkers of ...

Gene expression analysis identifies potential biomarkers of neurofibromatosis type 1 including adrenomedullin.

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  • Trent R Hummel
  • Walter J Jessen
  • Shyra J Miller
  • Lan Kluwe
  • Viktor Felix Mautner
  • Margaret R Wallace
  • Conxi Lázaro
  • Grier P Page
  • Paul F Worley
  • Bruce J Aronow
  • Elizabeth K Schorry
  • Nancy Ratner

Beteiligte Einrichtungen

Abstract

Plexiform neurofibromas (pNF) are Schwann cell tumors found in a third of individuals with neurofibromatosis type 1 (NF1). pNF can undergo transformation to malignant peripheral nerve sheath tumors (MPNST). There are no identified serum biomarkers of pNF tumor burden or transformation to MPNST. Serum biomarkers would be useful to verify NF1 diagnosis, monitor tumor burden, and/or detect transformation.

Bibliografische Daten

OriginalspracheDeutsch
Aufsatznummer20
ISSN1078-0432
StatusVeröffentlicht - 2010
pubmed 20739432