Gender-specific differences in energy metabolism during the initial phase of critical illness
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Gender-specific differences in energy metabolism during the initial phase of critical illness. / Drolz, A; Wewalka, M; Horvatits, T; Fuhrmann, V; Schneeweiss, B; Trauner, M; Zauner, C.
in: European journal of clinical nutrition, Jahrgang 68, Nr. 6, 01.06.2014, S. 707-11.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Gender-specific differences in energy metabolism during the initial phase of critical illness
AU - Drolz, A
AU - Wewalka, M
AU - Horvatits, T
AU - Fuhrmann, V
AU - Schneeweiss, B
AU - Trauner, M
AU - Zauner, C
PY - 2014/6/1
Y1 - 2014/6/1
N2 - Background/objectives:Women and men differ in substrate and energy metabolism. Such differences may affect energy requirements during the acute phase of critical illness.Subjects/methods:Data of 155 critically ill medical patients were reviewed for this study. Indirect calorimetry in each patient was performed within the first 72 h following admission to the medical intensive care unit after an overnight fast.Results:In overweight (body mass index (BMI)⩾25 kg/m(2)) but not in normal-weight patients, resting energy expenditure (REE) adjusted for body weight (REEaBW) differed significantly between women and men (17.2 (interquartile range (IQR) 15.2-20.7) vs 20.9 (IQR 17.9-23.4) kcal/kg/day, P<0.01). Similarly, REE adjusted for ideal body weight (REEaIBW) was significantly lower in women compared with men (25.5 (IQR 22.6-28.1) vs 28.0 (IQR 25.2-30.0) kcal/kg/day, P<0.05). In overweight patients, gender was identified as an independent predictor of REEaBW in the multivariate regression model (r=-2.57 (95% CI -4.57 to -0.57); P<0.05), even after adjustment for age, simplified acute physiology score (SAPS II), body temperature, body weight and height.Conclusions:REEaBW decreases with increasing body mass in both sexes. This relationship differs between women and men. Overweight critically ill women show significantly lower REEaBW and REEaIBW, respectively, compared with men. These findings could affect the current practice of nutritional support during the early phase of critical illness.
AB - Background/objectives:Women and men differ in substrate and energy metabolism. Such differences may affect energy requirements during the acute phase of critical illness.Subjects/methods:Data of 155 critically ill medical patients were reviewed for this study. Indirect calorimetry in each patient was performed within the first 72 h following admission to the medical intensive care unit after an overnight fast.Results:In overweight (body mass index (BMI)⩾25 kg/m(2)) but not in normal-weight patients, resting energy expenditure (REE) adjusted for body weight (REEaBW) differed significantly between women and men (17.2 (interquartile range (IQR) 15.2-20.7) vs 20.9 (IQR 17.9-23.4) kcal/kg/day, P<0.01). Similarly, REE adjusted for ideal body weight (REEaIBW) was significantly lower in women compared with men (25.5 (IQR 22.6-28.1) vs 28.0 (IQR 25.2-30.0) kcal/kg/day, P<0.05). In overweight patients, gender was identified as an independent predictor of REEaBW in the multivariate regression model (r=-2.57 (95% CI -4.57 to -0.57); P<0.05), even after adjustment for age, simplified acute physiology score (SAPS II), body temperature, body weight and height.Conclusions:REEaBW decreases with increasing body mass in both sexes. This relationship differs between women and men. Overweight critically ill women show significantly lower REEaBW and REEaIBW, respectively, compared with men. These findings could affect the current practice of nutritional support during the early phase of critical illness.
U2 - 10.1038/ejcn.2013.287
DO - 10.1038/ejcn.2013.287
M3 - SCORING: Journal article
C2 - 24424078
VL - 68
SP - 707
EP - 711
JO - EUR J CLIN NUTR
JF - EUR J CLIN NUTR
SN - 0954-3007
IS - 6
ER -
