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Gender-specific diagnostic performance of a new high-sensitivity cardiac troponin I assay for detection of acute myocardial infarction

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Gender-specific diagnostic performance of a new high-sensitivity cardiac troponin I assay for detection of acute myocardial infarction. / Schofer, Niklas; Brunner, Fabian J; Schlüter, Michael; Ojeda, Francisco; Zeller, Tanja; Baldus, Stephan; Bickel, Christoph; Lackner, Karl J; Münzel, Thomas; Tzikas, Stergios; Genth-Zotz, Sabine; Warnholtz, Ascan; Post, Felix; Keller, Till; Goldmann, Britta U; Blankenberg, Stefan.

in: EUR HEART J-ACUTE CA, Jahrgang 6, Nr. 1, 02.2017, S. 60-68.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Schofer, N, Brunner, FJ, Schlüter, M, Ojeda, F, Zeller, T, Baldus, S, Bickel, C, Lackner, KJ, Münzel, T, Tzikas, S, Genth-Zotz, S, Warnholtz, A, Post, F, Keller, T, Goldmann, BU & Blankenberg, S 2017, 'Gender-specific diagnostic performance of a new high-sensitivity cardiac troponin I assay for detection of acute myocardial infarction', EUR HEART J-ACUTE CA, Jg. 6, Nr. 1, S. 60-68. https://doi.org/10.1177/2048872615626660

APA

Schofer, N., Brunner, F. J., Schlüter, M., Ojeda, F., Zeller, T., Baldus, S., Bickel, C., Lackner, K. J., Münzel, T., Tzikas, S., Genth-Zotz, S., Warnholtz, A., Post, F., Keller, T., Goldmann, B. U., & Blankenberg, S. (2017). Gender-specific diagnostic performance of a new high-sensitivity cardiac troponin I assay for detection of acute myocardial infarction. EUR HEART J-ACUTE CA, 6(1), 60-68. https://doi.org/10.1177/2048872615626660

Vancouver

Schofer N, Brunner FJ, Schlüter M, Ojeda F, Zeller T, Baldus S et al. Gender-specific diagnostic performance of a new high-sensitivity cardiac troponin I assay for detection of acute myocardial infarction. EUR HEART J-ACUTE CA. 2017 Feb;6(1):60-68. https://doi.org/10.1177/2048872615626660

Bibtex

@article{2d141d8b48944422aa1b99a8d631b7ed,
title = "Gender-specific diagnostic performance of a new high-sensitivity cardiac troponin I assay for detection of acute myocardial infarction",
abstract = "BACKGROUND: The determination of cardiac troponin is essential for diagnosing myocardial infarction. A troponin I assay has recently been developed that provides the highest analytical sensitivity to date.METHODS: The analysis included 1560 patients with chest pain, of whom 1098 were diagnosed with non-coronary chest pain, 189 with unstable angina pectoris and 273 with non-ST-segment elevation myocardial infarction. The troponin I concentration was determined on admission (0 hours) and 3 hours later. The diagnostic algorithm incorporated troponin I elevation above the gender-specific 99th percentile as well as predefined relative or absolute 3-hour changes in the troponin I concentration (delta).RESULTS: The diagnostic criterion of troponin I above the 99th percentile resulted in a negative predictive value of 98.0% and 98.2% in men and women, respectively. For rule-in of non-ST-segment elevation myocardial infarction, the use of absolute deltas yielded higher positive predictive values and sensitivities compared to relative deltas. With detection rates of about 85% and 82% in men and women, respectively, non-ST-segment elevation myocardial infarction was diagnosed with a positive predictive value close to 84% in men and 80% in women.CONCLUSIONS: The investigational troponin I assay provides an excellent non-ST-segment elevation myocardial infarction rule out. With gender-specific differences, the application of absolute changes in troponin concentration was superior to relative changes to rule in patients with non-ST-segment elevation myocardial infarction.",
keywords = "Aged, Algorithms, Biomarkers/metabolism, Female, Humans, Male, Middle Aged, Myocardial Infarction/diagnosis, Non-ST Elevated Myocardial Infarction/diagnosis, Predictive Value of Tests, Sex Characteristics, Troponin I/metabolism",
author = "Niklas Schofer and Brunner, {Fabian J} and Michael Schl{\"u}ter and Francisco Ojeda and Tanja Zeller and Stephan Baldus and Christoph Bickel and Lackner, {Karl J} and Thomas M{\"u}nzel and Stergios Tzikas and Sabine Genth-Zotz and Ascan Warnholtz and Felix Post and Till Keller and Goldmann, {Britta U} and Stefan Blankenberg",
year = "2017",
month = feb,
doi = "10.1177/2048872615626660",
language = "English",
volume = "6",
pages = "60--68",
journal = "EUR HEART J-ACUTE CA",
issn = "2048-8726",
publisher = "SAGE Publications",
number = "1",

}

RIS

TY - JOUR

T1 - Gender-specific diagnostic performance of a new high-sensitivity cardiac troponin I assay for detection of acute myocardial infarction

AU - Schofer, Niklas

AU - Brunner, Fabian J

AU - Schlüter, Michael

AU - Ojeda, Francisco

AU - Zeller, Tanja

AU - Baldus, Stephan

AU - Bickel, Christoph

AU - Lackner, Karl J

AU - Münzel, Thomas

AU - Tzikas, Stergios

AU - Genth-Zotz, Sabine

AU - Warnholtz, Ascan

AU - Post, Felix

AU - Keller, Till

AU - Goldmann, Britta U

AU - Blankenberg, Stefan

PY - 2017/2

Y1 - 2017/2

N2 - BACKGROUND: The determination of cardiac troponin is essential for diagnosing myocardial infarction. A troponin I assay has recently been developed that provides the highest analytical sensitivity to date.METHODS: The analysis included 1560 patients with chest pain, of whom 1098 were diagnosed with non-coronary chest pain, 189 with unstable angina pectoris and 273 with non-ST-segment elevation myocardial infarction. The troponin I concentration was determined on admission (0 hours) and 3 hours later. The diagnostic algorithm incorporated troponin I elevation above the gender-specific 99th percentile as well as predefined relative or absolute 3-hour changes in the troponin I concentration (delta).RESULTS: The diagnostic criterion of troponin I above the 99th percentile resulted in a negative predictive value of 98.0% and 98.2% in men and women, respectively. For rule-in of non-ST-segment elevation myocardial infarction, the use of absolute deltas yielded higher positive predictive values and sensitivities compared to relative deltas. With detection rates of about 85% and 82% in men and women, respectively, non-ST-segment elevation myocardial infarction was diagnosed with a positive predictive value close to 84% in men and 80% in women.CONCLUSIONS: The investigational troponin I assay provides an excellent non-ST-segment elevation myocardial infarction rule out. With gender-specific differences, the application of absolute changes in troponin concentration was superior to relative changes to rule in patients with non-ST-segment elevation myocardial infarction.

AB - BACKGROUND: The determination of cardiac troponin is essential for diagnosing myocardial infarction. A troponin I assay has recently been developed that provides the highest analytical sensitivity to date.METHODS: The analysis included 1560 patients with chest pain, of whom 1098 were diagnosed with non-coronary chest pain, 189 with unstable angina pectoris and 273 with non-ST-segment elevation myocardial infarction. The troponin I concentration was determined on admission (0 hours) and 3 hours later. The diagnostic algorithm incorporated troponin I elevation above the gender-specific 99th percentile as well as predefined relative or absolute 3-hour changes in the troponin I concentration (delta).RESULTS: The diagnostic criterion of troponin I above the 99th percentile resulted in a negative predictive value of 98.0% and 98.2% in men and women, respectively. For rule-in of non-ST-segment elevation myocardial infarction, the use of absolute deltas yielded higher positive predictive values and sensitivities compared to relative deltas. With detection rates of about 85% and 82% in men and women, respectively, non-ST-segment elevation myocardial infarction was diagnosed with a positive predictive value close to 84% in men and 80% in women.CONCLUSIONS: The investigational troponin I assay provides an excellent non-ST-segment elevation myocardial infarction rule out. With gender-specific differences, the application of absolute changes in troponin concentration was superior to relative changes to rule in patients with non-ST-segment elevation myocardial infarction.

KW - Aged

KW - Algorithms

KW - Biomarkers/metabolism

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Myocardial Infarction/diagnosis

KW - Non-ST Elevated Myocardial Infarction/diagnosis

KW - Predictive Value of Tests

KW - Sex Characteristics

KW - Troponin I/metabolism

U2 - 10.1177/2048872615626660

DO - 10.1177/2048872615626660

M3 - SCORING: Journal article

C2 - 26772795

VL - 6

SP - 60

EP - 68

JO - EUR HEART J-ACUTE CA

JF - EUR HEART J-ACUTE CA

SN - 2048-8726

IS - 1

ER -