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Gender-affirming hormonal therapy induces a gender-concordant fecal metagenome transition in transgender individuals

Standard

Gender-affirming hormonal therapy induces a gender-concordant fecal metagenome transition in transgender individuals. / Liwinski, Timur; Auer, Matthias K; Schröder, Johanna; Pieknik, Ina; Casar, Christian; Schwinge, Dorothee; Henze, Lara; Stalla, Günter K; Lang, Undine E; von Klitzing, Alina (Autor/-in intern machen); Briken, Peer; Hildebrandt, Thomas; Desbuleux, Jeanne C; Biedermann, Sarah V; Holterhus, Paul-Martin; Bang, Corinna; Schramm, Christoph; Fuss, Johannes.

in: BMC MED, Jahrgang 22, Nr. 1, 02.09.2024, S. 346.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Liwinski, T, Auer, MK, Schröder, J, Pieknik, I, Casar, C, Schwinge, D, Henze, L, Stalla, GK, Lang, UE, von Klitzing, A, Briken, P, Hildebrandt, T, Desbuleux, JC, Biedermann, SV, Holterhus, P-M, Bang, C, Schramm, C & Fuss, J 2024, 'Gender-affirming hormonal therapy induces a gender-concordant fecal metagenome transition in transgender individuals', BMC MED, Jg. 22, Nr. 1, S. 346. https://doi.org/10.1186/s12916-024-03548-z

APA

Liwinski, T., Auer, M. K., Schröder, J., Pieknik, I., Casar, C., Schwinge, D., Henze, L., Stalla, G. K., Lang, U. E., von Klitzing, A., Briken, P., Hildebrandt, T., Desbuleux, J. C., Biedermann, S. V., Holterhus, P-M., Bang, C., Schramm, C., & Fuss, J. (2024). Gender-affirming hormonal therapy induces a gender-concordant fecal metagenome transition in transgender individuals. BMC MED, 22(1), 346. https://doi.org/10.1186/s12916-024-03548-z

Vancouver

Liwinski T, Auer MK, Schröder J, Pieknik I, Casar C, Schwinge D et al. Gender-affirming hormonal therapy induces a gender-concordant fecal metagenome transition in transgender individuals. BMC MED. 2024 Sep 2;22(1):346. https://doi.org/10.1186/s12916-024-03548-z

Bibtex

@article{63e935c1eafe4e7fb03ab03f4b5cd3d3,
title = "Gender-affirming hormonal therapy induces a gender-concordant fecal metagenome transition in transgender individuals",
abstract = "BACKGROUND: Limited data exists regarding gender-specific microbial alterations during gender-affirming hormonal therapy (GAHT) in transgender individuals. This study aimed to investigate the nuanced impact of sex steroids on gut microbiota taxonomy and function, addressing this gap. We prospectively analyzed gut metagenome changes associated with 12 weeks of GAHT in trans women and trans men, examining both taxonomic and functional shifts.METHODS: Thirty-six transgender individuals (17 trans women, 19 trans men) provided pre- and post-GAHT stool samples. Shotgun metagenomic sequencing was used to assess the changes in gut microbiota structure and potential function following GAHT.RESULTS: While alpha and beta diversity remained unchanged during transition, specific species, including Parabacteroides goldsteinii and Escherichia coli, exhibited significant abundance shifts aligned with affirmed gender. Overall functional metagenome analysis showed a statistically significant effect of gender and transition (R2 = 4.1%, P = 0.0115), emphasizing transitions aligned with affirmed gender, particularly in fatty acid-related metabolism.CONCLUSIONS: This study provides compelling evidence of distinct taxonomic and functional profiles in the gut microbiota between trans men and women. GAHT induces androgenization in trans men and feminization in trans women, potentially impacting physiological and health-related outcomes.TRIAL REGISTRATION: Clinicaltrials.gov NCT02185274.",
keywords = "Humans, Female, Male, Transgender Persons, Adult, Feces/microbiology, Gastrointestinal Microbiome/drug effects, Prospective Studies, Metagenome, Young Adult, Middle Aged",
author = "Timur Liwinski and Auer, {Matthias K} and Johanna Schr{\"o}der and Ina Pieknik and Christian Casar and Dorothee Schwinge and Lara Henze and Stalla, {G{\"u}nter K} and Lang, {Undine E} and {von Klitzing}, Alina and Peer Briken and Thomas Hildebrandt and Desbuleux, {Jeanne C} and Biedermann, {Sarah V} and Paul-Martin Holterhus and Corinna Bang and Christoph Schramm and Johannes Fuss",
note = "{\textcopyright} 2024. The Author(s).",
year = "2024",
month = sep,
day = "2",
doi = "10.1186/s12916-024-03548-z",
language = "English",
volume = "22",
pages = "346",
journal = "BMC MED",
issn = "1741-7015",
publisher = "BioMed Central Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - Gender-affirming hormonal therapy induces a gender-concordant fecal metagenome transition in transgender individuals

AU - Liwinski, Timur

AU - Auer, Matthias K

AU - Schröder, Johanna

AU - Pieknik, Ina

AU - Casar, Christian

AU - Schwinge, Dorothee

AU - Henze, Lara

AU - Stalla, Günter K

AU - Lang, Undine E

AU - Briken, Peer

AU - Hildebrandt, Thomas

AU - Desbuleux, Jeanne C

AU - Biedermann, Sarah V

AU - Holterhus, Paul-Martin

AU - Bang, Corinna

AU - Schramm, Christoph

AU - Fuss, Johannes

A2 - von Klitzing, Alina

N1 - © 2024. The Author(s).

PY - 2024/9/2

Y1 - 2024/9/2

N2 - BACKGROUND: Limited data exists regarding gender-specific microbial alterations during gender-affirming hormonal therapy (GAHT) in transgender individuals. This study aimed to investigate the nuanced impact of sex steroids on gut microbiota taxonomy and function, addressing this gap. We prospectively analyzed gut metagenome changes associated with 12 weeks of GAHT in trans women and trans men, examining both taxonomic and functional shifts.METHODS: Thirty-six transgender individuals (17 trans women, 19 trans men) provided pre- and post-GAHT stool samples. Shotgun metagenomic sequencing was used to assess the changes in gut microbiota structure and potential function following GAHT.RESULTS: While alpha and beta diversity remained unchanged during transition, specific species, including Parabacteroides goldsteinii and Escherichia coli, exhibited significant abundance shifts aligned with affirmed gender. Overall functional metagenome analysis showed a statistically significant effect of gender and transition (R2 = 4.1%, P = 0.0115), emphasizing transitions aligned with affirmed gender, particularly in fatty acid-related metabolism.CONCLUSIONS: This study provides compelling evidence of distinct taxonomic and functional profiles in the gut microbiota between trans men and women. GAHT induces androgenization in trans men and feminization in trans women, potentially impacting physiological and health-related outcomes.TRIAL REGISTRATION: Clinicaltrials.gov NCT02185274.

AB - BACKGROUND: Limited data exists regarding gender-specific microbial alterations during gender-affirming hormonal therapy (GAHT) in transgender individuals. This study aimed to investigate the nuanced impact of sex steroids on gut microbiota taxonomy and function, addressing this gap. We prospectively analyzed gut metagenome changes associated with 12 weeks of GAHT in trans women and trans men, examining both taxonomic and functional shifts.METHODS: Thirty-six transgender individuals (17 trans women, 19 trans men) provided pre- and post-GAHT stool samples. Shotgun metagenomic sequencing was used to assess the changes in gut microbiota structure and potential function following GAHT.RESULTS: While alpha and beta diversity remained unchanged during transition, specific species, including Parabacteroides goldsteinii and Escherichia coli, exhibited significant abundance shifts aligned with affirmed gender. Overall functional metagenome analysis showed a statistically significant effect of gender and transition (R2 = 4.1%, P = 0.0115), emphasizing transitions aligned with affirmed gender, particularly in fatty acid-related metabolism.CONCLUSIONS: This study provides compelling evidence of distinct taxonomic and functional profiles in the gut microbiota between trans men and women. GAHT induces androgenization in trans men and feminization in trans women, potentially impacting physiological and health-related outcomes.TRIAL REGISTRATION: Clinicaltrials.gov NCT02185274.

KW - Humans

KW - Female

KW - Male

KW - Transgender Persons

KW - Adult

KW - Feces/microbiology

KW - Gastrointestinal Microbiome/drug effects

KW - Prospective Studies

KW - Metagenome

KW - Young Adult

KW - Middle Aged

U2 - 10.1186/s12916-024-03548-z

DO - 10.1186/s12916-024-03548-z

M3 - SCORING: Journal article

C2 - 39218875

VL - 22

SP - 346

JO - BMC MED

JF - BMC MED

SN - 1741-7015

IS - 1

ER -