Gender differences in patients with carotid stenosis
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Gender differences in patients with carotid stenosis. / Stoberock, Konstanze; Debus, Eike Sebastian; Atlihan, Gülsen; Daum, Günter; Larena-Avellaneda, Axel; Eifert, Sandra; Wipper, Sabine.
in: VASA, Jahrgang 45, Nr. 1, 01.2016, S. 11-16.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Gender differences in patients with carotid stenosis
AU - Stoberock, Konstanze
AU - Debus, Eike Sebastian
AU - Atlihan, Gülsen
AU - Daum, Günter
AU - Larena-Avellaneda, Axel
AU - Eifert, Sandra
AU - Wipper, Sabine
PY - 2016/1
Y1 - 2016/1
N2 - This overview analyses gender differences in prevalence, epidemiology, risk factors and therapy in patients with carotid stenosis in a systematic review. Ischemic stroke is a leading cause of death in Western society, where about 20% of cases are triggered by a carotid stenosis or occlusion, which occurs more frequently in men than in women. The stroke-protective effect of carotid endarterectomy is greater in men. Men have lower peri-procedural stroke and death rates. Particularly men with carotid stenosis and a life expectancy of at least 5 years benefit from surgical treatment. Also, the recurrence rate of ipsilateral stroke 5 years after initial surgery is lower in men than in women. It is not yet fully clarified whether there are significant gender differences regarding the outcome after endovascular versus surgical treatment. Gender differences in the outcome of carotid artery repair may be caused by biological, anatomical (smaller vessel diameter in women) or hormonal differences as well as a protracted development of atherosclerotic changes in women and different plaque morphology. Moreover, women are on average older at the time of surgery and their surgical treatment is often delayed. To reduce the risk of stroke and to improve treatment outcome especially for women, further research on gender differences and their causes is mandatory and promising.
AB - This overview analyses gender differences in prevalence, epidemiology, risk factors and therapy in patients with carotid stenosis in a systematic review. Ischemic stroke is a leading cause of death in Western society, where about 20% of cases are triggered by a carotid stenosis or occlusion, which occurs more frequently in men than in women. The stroke-protective effect of carotid endarterectomy is greater in men. Men have lower peri-procedural stroke and death rates. Particularly men with carotid stenosis and a life expectancy of at least 5 years benefit from surgical treatment. Also, the recurrence rate of ipsilateral stroke 5 years after initial surgery is lower in men than in women. It is not yet fully clarified whether there are significant gender differences regarding the outcome after endovascular versus surgical treatment. Gender differences in the outcome of carotid artery repair may be caused by biological, anatomical (smaller vessel diameter in women) or hormonal differences as well as a protracted development of atherosclerotic changes in women and different plaque morphology. Moreover, women are on average older at the time of surgery and their surgical treatment is often delayed. To reduce the risk of stroke and to improve treatment outcome especially for women, further research on gender differences and their causes is mandatory and promising.
KW - Angioplasty/instrumentation
KW - Asymptomatic Diseases
KW - Carotid Stenosis/diagnosis
KW - Endarterectomy, Carotid
KW - Female
KW - Health Status Disparities
KW - Healthcare Disparities
KW - Humans
KW - Male
KW - Prevalence
KW - Recurrence
KW - Risk Assessment
KW - Risk Factors
KW - Sex Factors
KW - Stroke/diagnosis
KW - Time Factors
KW - Treatment Outcome
U2 - 10.1024/0301-1526/a000490
DO - 10.1024/0301-1526/a000490
M3 - SCORING: Review article
C2 - 26986705
VL - 45
SP - 11
EP - 16
JO - VASA
JF - VASA
SN - 0301-1526
IS - 1
ER -