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FUT 2 polymorphism and outcome in very-low-birth-weight infants

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FUT 2 polymorphism and outcome in very-low-birth-weight infants. / Demmert, Martin; Schaper, Anne; Pagel, Julia; Gebauer, Corinna; Emeis, Michael; Heitmann, Friedhelm; Kribs, Angela; Siegel, Jens; Müller, Dirk; Keller-Wackerbauer, Annette; Gerleve, Hubert; Wieg, Christian; Herting, Egbert; Göpel, Wolfgang; Härtel, Christoph.

in: PEDIATR RES, Jahrgang 77, Nr. 4, 04.2015, S. 586-90.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Demmert, M, Schaper, A, Pagel, J, Gebauer, C, Emeis, M, Heitmann, F, Kribs, A, Siegel, J, Müller, D, Keller-Wackerbauer, A, Gerleve, H, Wieg, C, Herting, E, Göpel, W & Härtel, C 2015, 'FUT 2 polymorphism and outcome in very-low-birth-weight infants', PEDIATR RES, Jg. 77, Nr. 4, S. 586-90. https://doi.org/10.1038/pr.2015.1

APA

Demmert, M., Schaper, A., Pagel, J., Gebauer, C., Emeis, M., Heitmann, F., Kribs, A., Siegel, J., Müller, D., Keller-Wackerbauer, A., Gerleve, H., Wieg, C., Herting, E., Göpel, W., & Härtel, C. (2015). FUT 2 polymorphism and outcome in very-low-birth-weight infants. PEDIATR RES, 77(4), 586-90. https://doi.org/10.1038/pr.2015.1

Vancouver

Demmert M, Schaper A, Pagel J, Gebauer C, Emeis M, Heitmann F et al. FUT 2 polymorphism and outcome in very-low-birth-weight infants. PEDIATR RES. 2015 Apr;77(4):586-90. https://doi.org/10.1038/pr.2015.1

Bibtex

@article{2fdec59e967d45fe897c933ea8711ef6,
title = "FUT 2 polymorphism and outcome in very-low-birth-weight infants",
abstract = "BACKGROUND: To determine whether the secretor gene fucosyltransferase (FUT)2 polymorphism G428A is predictive for adverse outcomes in a large cohort of very-low-birth weight (VLBW) infants.METHODS: We prospectively enrolled 2,406 VLBW infants from the population-based multicenter cohort of the German Neonatal network cohort (2009-2011). The secretor genotype (rs601338) was assessed from DNA samples extracted from buccal swabs. Primary study outcomes were clinical sepsis, blood-culture confirmed sepsis, intracerebral hemorrhage (ICH), necrotizing enterocolitis (NEC) or focal intestinal perforation requiring surgery, and death.RESULTS: Based on the assumption of a recessive genetic model, AA individuals had a higher incidence of ICH (AA: 19.0% vs.GG/AG: 14.9%, P = 0.04) which was not significant in the additive genetic model (multivariable logistic regression analysis; allele carriers: 365 cases, 1,685 controls; OR: 1.2; 95% CI: 0.99-1.4; P = 0.06). Other outcomes were not influenced by FUT2 genotype in either genetic model.CONCLUSION: This large-scale multicenter study did not confirm previously reported associations between FUT2 genotype and adverse outcomes in preterm infants.",
keywords = "Cerebral Hemorrhage/genetics, Enterocolitis, Necrotizing/genetics, Female, Fucosyltransferases/genetics, Genes, Recessive, Genetic Predisposition to Disease, Genotype, Humans, Infant, Infant, Newborn, Infant, Premature, Infant, Premature, Diseases, Infant, Very Low Birth Weight, Intestinal Perforation/genetics, Intestines/abnormalities, Male, Polymorphism, Genetic, Prospective Studies, Sepsis/genetics",
author = "Martin Demmert and Anne Schaper and Julia Pagel and Corinna Gebauer and Michael Emeis and Friedhelm Heitmann and Angela Kribs and Jens Siegel and Dirk M{\"u}ller and Annette Keller-Wackerbauer and Hubert Gerleve and Christian Wieg and Egbert Herting and Wolfgang G{\"o}pel and Christoph H{\"a}rtel",
year = "2015",
month = apr,
doi = "10.1038/pr.2015.1",
language = "English",
volume = "77",
pages = "586--90",
journal = "PEDIATR RES",
issn = "0031-3998",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

RIS

TY - JOUR

T1 - FUT 2 polymorphism and outcome in very-low-birth-weight infants

AU - Demmert, Martin

AU - Schaper, Anne

AU - Pagel, Julia

AU - Gebauer, Corinna

AU - Emeis, Michael

AU - Heitmann, Friedhelm

AU - Kribs, Angela

AU - Siegel, Jens

AU - Müller, Dirk

AU - Keller-Wackerbauer, Annette

AU - Gerleve, Hubert

AU - Wieg, Christian

AU - Herting, Egbert

AU - Göpel, Wolfgang

AU - Härtel, Christoph

PY - 2015/4

Y1 - 2015/4

N2 - BACKGROUND: To determine whether the secretor gene fucosyltransferase (FUT)2 polymorphism G428A is predictive for adverse outcomes in a large cohort of very-low-birth weight (VLBW) infants.METHODS: We prospectively enrolled 2,406 VLBW infants from the population-based multicenter cohort of the German Neonatal network cohort (2009-2011). The secretor genotype (rs601338) was assessed from DNA samples extracted from buccal swabs. Primary study outcomes were clinical sepsis, blood-culture confirmed sepsis, intracerebral hemorrhage (ICH), necrotizing enterocolitis (NEC) or focal intestinal perforation requiring surgery, and death.RESULTS: Based on the assumption of a recessive genetic model, AA individuals had a higher incidence of ICH (AA: 19.0% vs.GG/AG: 14.9%, P = 0.04) which was not significant in the additive genetic model (multivariable logistic regression analysis; allele carriers: 365 cases, 1,685 controls; OR: 1.2; 95% CI: 0.99-1.4; P = 0.06). Other outcomes were not influenced by FUT2 genotype in either genetic model.CONCLUSION: This large-scale multicenter study did not confirm previously reported associations between FUT2 genotype and adverse outcomes in preterm infants.

AB - BACKGROUND: To determine whether the secretor gene fucosyltransferase (FUT)2 polymorphism G428A is predictive for adverse outcomes in a large cohort of very-low-birth weight (VLBW) infants.METHODS: We prospectively enrolled 2,406 VLBW infants from the population-based multicenter cohort of the German Neonatal network cohort (2009-2011). The secretor genotype (rs601338) was assessed from DNA samples extracted from buccal swabs. Primary study outcomes were clinical sepsis, blood-culture confirmed sepsis, intracerebral hemorrhage (ICH), necrotizing enterocolitis (NEC) or focal intestinal perforation requiring surgery, and death.RESULTS: Based on the assumption of a recessive genetic model, AA individuals had a higher incidence of ICH (AA: 19.0% vs.GG/AG: 14.9%, P = 0.04) which was not significant in the additive genetic model (multivariable logistic regression analysis; allele carriers: 365 cases, 1,685 controls; OR: 1.2; 95% CI: 0.99-1.4; P = 0.06). Other outcomes were not influenced by FUT2 genotype in either genetic model.CONCLUSION: This large-scale multicenter study did not confirm previously reported associations between FUT2 genotype and adverse outcomes in preterm infants.

KW - Cerebral Hemorrhage/genetics

KW - Enterocolitis, Necrotizing/genetics

KW - Female

KW - Fucosyltransferases/genetics

KW - Genes, Recessive

KW - Genetic Predisposition to Disease

KW - Genotype

KW - Humans

KW - Infant

KW - Infant, Newborn

KW - Infant, Premature

KW - Infant, Premature, Diseases

KW - Infant, Very Low Birth Weight

KW - Intestinal Perforation/genetics

KW - Intestines/abnormalities

KW - Male

KW - Polymorphism, Genetic

KW - Prospective Studies

KW - Sepsis/genetics

U2 - 10.1038/pr.2015.1

DO - 10.1038/pr.2015.1

M3 - SCORING: Journal article

C2 - 25642664

VL - 77

SP - 586

EP - 590

JO - PEDIATR RES

JF - PEDIATR RES

SN - 0031-3998

IS - 4

ER -