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Fungal "colonisation" is associated with increased mortality in medical intensive care unit patients with liver cirrhosis

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Fungal "colonisation" is associated with increased mortality in medical intensive care unit patients with liver cirrhosis. / Lahmer, Tobias; Messer, Marlena; Mayr, Ulrich; Saugel, Bernd; Noe, Sebastian; Schultheiss, Caroline; Thies, Philipp; Spinner, Christoph; Nennstiel, Simon; Schwerdtfeger, Christiane; Phillip, Veit; Schmid, Roland M; Huber, Wolfgang.

in: MYCOPATHOLOGIA, Jahrgang 179, Nr. 1-2, 01.02.2015, S. 63-71.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Lahmer, T, Messer, M, Mayr, U, Saugel, B, Noe, S, Schultheiss, C, Thies, P, Spinner, C, Nennstiel, S, Schwerdtfeger, C, Phillip, V, Schmid, RM & Huber, W 2015, 'Fungal "colonisation" is associated with increased mortality in medical intensive care unit patients with liver cirrhosis', MYCOPATHOLOGIA, Jg. 179, Nr. 1-2, S. 63-71. https://doi.org/10.1007/s11046-014-9825-6

APA

Lahmer, T., Messer, M., Mayr, U., Saugel, B., Noe, S., Schultheiss, C., Thies, P., Spinner, C., Nennstiel, S., Schwerdtfeger, C., Phillip, V., Schmid, R. M., & Huber, W. (2015). Fungal "colonisation" is associated with increased mortality in medical intensive care unit patients with liver cirrhosis. MYCOPATHOLOGIA, 179(1-2), 63-71. https://doi.org/10.1007/s11046-014-9825-6

Vancouver

Lahmer T, Messer M, Mayr U, Saugel B, Noe S, Schultheiss C et al. Fungal "colonisation" is associated with increased mortality in medical intensive care unit patients with liver cirrhosis. MYCOPATHOLOGIA. 2015 Feb 1;179(1-2):63-71. https://doi.org/10.1007/s11046-014-9825-6

Bibtex

@article{1456a5b5ff6e4de0a59e9910e76c25f9,
title = "Fungal {"}colonisation{"} is associated with increased mortality in medical intensive care unit patients with liver cirrhosis",
abstract = "OBJECTIVES: Patients with liver cirrhosis are at increased risk for fungal infections. However, distinction of fungal colonisation (FC) and invasive mycoses is difficult. Aim of this study was to analyse the impact of FC on mortality of cirrhotic ICU-patients.METHODS: Retrospective mortality analysis of a prospectively maintained database on 120 cirrhotic patients with and without FC. Comparison to 120 noncirrhotic controls matched for APACHE-II (24.9 ± 3.7 vs. 25.0 ± 2.6; p = 0.263).RESULTS: About 69/120 (58%) of patients with cirrhosis had FC. These patients had significantly higher APACHE-II score and mortality compared to cirrhotic patients without FC (27 ± 3 vs. 23 ± 4, p < 0.001; 78 vs. 35%, p < 0.001). In multivariate analysis, FC was independently (p = 0.047) associated to mortality. Mortality of noncirrhotic patients with FC (14/31; 45.2%) was not different to noncirrhotic controls without FC [28/89 (31.2%; p = 0.168)]. Similarly, in multivariate analysis of noncirrhotics, APACHE-II (p < 0.001), but not FC, was independently associated to mortality. Multiple regression analysis of all 240 cirrhotic and noncirrhotic patients demonstrated that APACHE-II (p < 0.001), cirrhosis (p = 0.001) and FC (p = 0.049) were independently associated with mortality.CONCLUSION: Fungal {"}colonisation{"} is independently associated to mortality in cirrhotic ICU-patients. Early antimycotic therapy should be considered in critically ill cirrhotic patients with FC.",
author = "Tobias Lahmer and Marlena Messer and Ulrich Mayr and Bernd Saugel and Sebastian Noe and Caroline Schultheiss and Philipp Thies and Christoph Spinner and Simon Nennstiel and Christiane Schwerdtfeger and Veit Phillip and Schmid, {Roland M} and Wolfgang Huber",
year = "2015",
month = feb,
day = "1",
doi = "10.1007/s11046-014-9825-6",
language = "English",
volume = "179",
pages = "63--71",
journal = "MYCOPATHOLOGIA",
issn = "0301-486X",
publisher = "Springer Netherlands",
number = "1-2",

}

RIS

TY - JOUR

T1 - Fungal "colonisation" is associated with increased mortality in medical intensive care unit patients with liver cirrhosis

AU - Lahmer, Tobias

AU - Messer, Marlena

AU - Mayr, Ulrich

AU - Saugel, Bernd

AU - Noe, Sebastian

AU - Schultheiss, Caroline

AU - Thies, Philipp

AU - Spinner, Christoph

AU - Nennstiel, Simon

AU - Schwerdtfeger, Christiane

AU - Phillip, Veit

AU - Schmid, Roland M

AU - Huber, Wolfgang

PY - 2015/2/1

Y1 - 2015/2/1

N2 - OBJECTIVES: Patients with liver cirrhosis are at increased risk for fungal infections. However, distinction of fungal colonisation (FC) and invasive mycoses is difficult. Aim of this study was to analyse the impact of FC on mortality of cirrhotic ICU-patients.METHODS: Retrospective mortality analysis of a prospectively maintained database on 120 cirrhotic patients with and without FC. Comparison to 120 noncirrhotic controls matched for APACHE-II (24.9 ± 3.7 vs. 25.0 ± 2.6; p = 0.263).RESULTS: About 69/120 (58%) of patients with cirrhosis had FC. These patients had significantly higher APACHE-II score and mortality compared to cirrhotic patients without FC (27 ± 3 vs. 23 ± 4, p < 0.001; 78 vs. 35%, p < 0.001). In multivariate analysis, FC was independently (p = 0.047) associated to mortality. Mortality of noncirrhotic patients with FC (14/31; 45.2%) was not different to noncirrhotic controls without FC [28/89 (31.2%; p = 0.168)]. Similarly, in multivariate analysis of noncirrhotics, APACHE-II (p < 0.001), but not FC, was independently associated to mortality. Multiple regression analysis of all 240 cirrhotic and noncirrhotic patients demonstrated that APACHE-II (p < 0.001), cirrhosis (p = 0.001) and FC (p = 0.049) were independently associated with mortality.CONCLUSION: Fungal "colonisation" is independently associated to mortality in cirrhotic ICU-patients. Early antimycotic therapy should be considered in critically ill cirrhotic patients with FC.

AB - OBJECTIVES: Patients with liver cirrhosis are at increased risk for fungal infections. However, distinction of fungal colonisation (FC) and invasive mycoses is difficult. Aim of this study was to analyse the impact of FC on mortality of cirrhotic ICU-patients.METHODS: Retrospective mortality analysis of a prospectively maintained database on 120 cirrhotic patients with and without FC. Comparison to 120 noncirrhotic controls matched for APACHE-II (24.9 ± 3.7 vs. 25.0 ± 2.6; p = 0.263).RESULTS: About 69/120 (58%) of patients with cirrhosis had FC. These patients had significantly higher APACHE-II score and mortality compared to cirrhotic patients without FC (27 ± 3 vs. 23 ± 4, p < 0.001; 78 vs. 35%, p < 0.001). In multivariate analysis, FC was independently (p = 0.047) associated to mortality. Mortality of noncirrhotic patients with FC (14/31; 45.2%) was not different to noncirrhotic controls without FC [28/89 (31.2%; p = 0.168)]. Similarly, in multivariate analysis of noncirrhotics, APACHE-II (p < 0.001), but not FC, was independently associated to mortality. Multiple regression analysis of all 240 cirrhotic and noncirrhotic patients demonstrated that APACHE-II (p < 0.001), cirrhosis (p = 0.001) and FC (p = 0.049) were independently associated with mortality.CONCLUSION: Fungal "colonisation" is independently associated to mortality in cirrhotic ICU-patients. Early antimycotic therapy should be considered in critically ill cirrhotic patients with FC.

U2 - 10.1007/s11046-014-9825-6

DO - 10.1007/s11046-014-9825-6

M3 - SCORING: Journal article

C2 - 25348847

VL - 179

SP - 63

EP - 71

JO - MYCOPATHOLOGIA

JF - MYCOPATHOLOGIA

SN - 0301-486X

IS - 1-2

ER -