Fundus Autofluorescence Imaging in Macular Telangiectasia Type 2: MacTel Study Report Number 9
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Fundus Autofluorescence Imaging in Macular Telangiectasia Type 2: MacTel Study Report Number 9. / Pauleikhoff, Laurenz; Heeren, Tjebo F C; Gliem, Martin; Lim, Ernest; Pauleikhoff, Daniel; Holz, Frank G; Clemons, Traci; Balaskas, Konstantinos; MACTEL STUDY GROUP; Egan, Catherine A; Charbel Issa, Peter.
in: AM J OPHTHALMOL, Jahrgang 228, 08.2021, S. 27-34.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Fundus Autofluorescence Imaging in Macular Telangiectasia Type 2: MacTel Study Report Number 9
AU - Pauleikhoff, Laurenz
AU - Heeren, Tjebo F C
AU - Gliem, Martin
AU - Lim, Ernest
AU - Pauleikhoff, Daniel
AU - Holz, Frank G
AU - Clemons, Traci
AU - Balaskas, Konstantinos
AU - MACTEL STUDY GROUP
AU - Egan, Catherine A
AU - Charbel Issa, Peter
N1 - Copyright © 2021 Elsevier Inc. All rights reserved.
PY - 2021/8
Y1 - 2021/8
N2 - PURPOSE: To investigate the role of fundus autofluorescence (FAF) imaging in the diagnosis of macular telangiectasia type 2 (MacTel) and to describe disease-associated FAF patterns and their origin.DESIGN: Cross-sectional multicenter study METHODS: FAF images were collected from the multicenter MacTel Natural History Observation and Registry Study. In a first qualitative approach, common FAF phenotypes were defined and correlated with multimodal imaging. We then evaluated how many eyes showed FAF changes, and temporal vs nasal asymmetry of FAF changes was graded. Finally, 100 eyes of MacTel patients and 100 control eyes (50 normal eyes and 50 eyes with other macular diseases) were combined and 2 masked graders assessed the presence of MacTel based on FAF images alone.RESULTS: The study included 807 eyes of 420 patients (33 eyes were excluded owing to poor image quality). Loss of macular pigment, cystoid spaces, pigment plaques, neovascular membranes, and ectatic vascular changes commonly caused characteristic changes on FAF images. All MacTel patients had macular FAF changes in at least 1 eye. In 95% of eyes, these changes were more pronounced temporally than nasally. Common FAF patterns were increased (60%) and mixed/decreased FAF (38%) and/or visibility of vascular changes such as blunted vessels or ectatic capillaries (79%). Based on those features, high diagnostic performance was achieved for detection of the disease based on FAF alone (Youden index up to 0.91).CONCLUSIONS: The study demonstrates that MacTel is consistently associated with disease-specific changes on FAF imaging. Those changes are typically more pronounced in the temporal parafovea.
AB - PURPOSE: To investigate the role of fundus autofluorescence (FAF) imaging in the diagnosis of macular telangiectasia type 2 (MacTel) and to describe disease-associated FAF patterns and their origin.DESIGN: Cross-sectional multicenter study METHODS: FAF images were collected from the multicenter MacTel Natural History Observation and Registry Study. In a first qualitative approach, common FAF phenotypes were defined and correlated with multimodal imaging. We then evaluated how many eyes showed FAF changes, and temporal vs nasal asymmetry of FAF changes was graded. Finally, 100 eyes of MacTel patients and 100 control eyes (50 normal eyes and 50 eyes with other macular diseases) were combined and 2 masked graders assessed the presence of MacTel based on FAF images alone.RESULTS: The study included 807 eyes of 420 patients (33 eyes were excluded owing to poor image quality). Loss of macular pigment, cystoid spaces, pigment plaques, neovascular membranes, and ectatic vascular changes commonly caused characteristic changes on FAF images. All MacTel patients had macular FAF changes in at least 1 eye. In 95% of eyes, these changes were more pronounced temporally than nasally. Common FAF patterns were increased (60%) and mixed/decreased FAF (38%) and/or visibility of vascular changes such as blunted vessels or ectatic capillaries (79%). Based on those features, high diagnostic performance was achieved for detection of the disease based on FAF alone (Youden index up to 0.91).CONCLUSIONS: The study demonstrates that MacTel is consistently associated with disease-specific changes on FAF imaging. Those changes are typically more pronounced in the temporal parafovea.
KW - Cross-Sectional Studies
KW - Fluorescein Angiography/methods
KW - Fundus Oculi
KW - Humans
KW - Macula Lutea/diagnostic imaging
KW - Multimodal Imaging
KW - Ophthalmoscopy/methods
KW - Reproducibility of Results
KW - Retinal Telangiectasis/diagnosis
KW - Retinal Vessels/diagnostic imaging
KW - Tomography, Optical Coherence/methods
KW - Visual Acuity
U2 - 10.1016/j.ajo.2021.03.022
DO - 10.1016/j.ajo.2021.03.022
M3 - SCORING: Journal article
C2 - 33775659
VL - 228
SP - 27
EP - 34
JO - AM J OPHTHALMOL
JF - AM J OPHTHALMOL
SN - 0002-9394
ER -
