Functional limitations 12 months after SARS-CoV-2 infection correlate with initial disease severity: An observational study of cardiopulmonary exercise capacity testing in COVID-19 convalescents
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Functional limitations 12 months after SARS-CoV-2 infection correlate with initial disease severity: An observational study of cardiopulmonary exercise capacity testing in COVID-19 convalescents. / Steinbeis, Fridolin; Knape, Philipp; Mittermaier, Mirja; Helbig, Elisa Theresa; Tober-Lau, Pinkus; Thibeault, Charlotte; Lippert, Lena Johanna; Xiang, Weiwei; Müller-Plathe, Moritz; Steinbrecher, Sarah; Meyer, Hans-Jakob; Ring, Raphaela Maria; Ruwwe-Glösenkamp, Christoph; Alius, Florian; Li, Yaosi; Müller-Redetzky, Holger; Uhrig, Alexander; Lingscheid, Tilman; Grund, Daniel; Temmesfeld-Wollbrück, Bettina; Suttorp, Norbert; Sander, Leif Erik; Kurth, Florian; Witzenrath, Martin; Zoller, Thomas.
in: RESP MED, Jahrgang 202, 106968, 10.2022.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Functional limitations 12 months after SARS-CoV-2 infection correlate with initial disease severity: An observational study of cardiopulmonary exercise capacity testing in COVID-19 convalescents
AU - Steinbeis, Fridolin
AU - Knape, Philipp
AU - Mittermaier, Mirja
AU - Helbig, Elisa Theresa
AU - Tober-Lau, Pinkus
AU - Thibeault, Charlotte
AU - Lippert, Lena Johanna
AU - Xiang, Weiwei
AU - Müller-Plathe, Moritz
AU - Steinbrecher, Sarah
AU - Meyer, Hans-Jakob
AU - Ring, Raphaela Maria
AU - Ruwwe-Glösenkamp, Christoph
AU - Alius, Florian
AU - Li, Yaosi
AU - Müller-Redetzky, Holger
AU - Uhrig, Alexander
AU - Lingscheid, Tilman
AU - Grund, Daniel
AU - Temmesfeld-Wollbrück, Bettina
AU - Suttorp, Norbert
AU - Sander, Leif Erik
AU - Kurth, Florian
AU - Witzenrath, Martin
AU - Zoller, Thomas
N1 - Copyright © 2022 Elsevier Ltd. All rights reserved.
PY - 2022/10
Y1 - 2022/10
N2 - BACKGROUND: Cardiopulmonary Exercise Testing (CPET) provides a comprehensive assessment of pulmonary, cardiovascular and musculosceletal function. Reduced CPET performance could be an indicator for chronic morbidity after COVID-19.METHODS: Patients ≥18 years with confirmed PCR positive SARS-CoV-2 infection were offered to participate in a prospective observational study of clinical course and outcomes of COVID-19. 54 patients completed CPET, questionnaires on respiratory quality of life and performed pulmonary function tests 12 months after SARS-CoV-2 infection.RESULTS: At 12 months after SARS-CoV-2 infection, 46.3% of participants had a peak performance and 33.3% a peak oxygen uptake of <80% of the predicted values, respectively. Further impairments were observed in diffusion capacity and ventilatory efficiency. Functional limitations were particularly pronounced in patients after invasive mechanical ventilation and extracorporeal membrane oxygenation treatment. Ventilatory capacity was reduced <80% of predicted values in 55.6% of participants, independent from initial clinical severity. Patient reported dyspnea and respiratory quality of life after COVID-19 correlated with CPET performance and parameters of gas exchange. Risk factors for reduced CPET performance 12 months after COVID-19 were prior intensive care treatment (OR 5.58, p = 0.004), SGRQ outcome >25 points (OR 3.48, p = 0.03) and reduced DLCO (OR 3.01, p = 0.054).CONCLUSIONS: Functional limitations causing chronic morbidity in COVID-19 survivors persist over 12 months after SARS-CoV-2 infection. These limitations were particularly seen in parameters of overall performance and gas exchange resulting from muscular deconditioning and lung parenchymal changes. Patient reported reduced respiratory quality of life was a risk factor for adverse CPET performance.
AB - BACKGROUND: Cardiopulmonary Exercise Testing (CPET) provides a comprehensive assessment of pulmonary, cardiovascular and musculosceletal function. Reduced CPET performance could be an indicator for chronic morbidity after COVID-19.METHODS: Patients ≥18 years with confirmed PCR positive SARS-CoV-2 infection were offered to participate in a prospective observational study of clinical course and outcomes of COVID-19. 54 patients completed CPET, questionnaires on respiratory quality of life and performed pulmonary function tests 12 months after SARS-CoV-2 infection.RESULTS: At 12 months after SARS-CoV-2 infection, 46.3% of participants had a peak performance and 33.3% a peak oxygen uptake of <80% of the predicted values, respectively. Further impairments were observed in diffusion capacity and ventilatory efficiency. Functional limitations were particularly pronounced in patients after invasive mechanical ventilation and extracorporeal membrane oxygenation treatment. Ventilatory capacity was reduced <80% of predicted values in 55.6% of participants, independent from initial clinical severity. Patient reported dyspnea and respiratory quality of life after COVID-19 correlated with CPET performance and parameters of gas exchange. Risk factors for reduced CPET performance 12 months after COVID-19 were prior intensive care treatment (OR 5.58, p = 0.004), SGRQ outcome >25 points (OR 3.48, p = 0.03) and reduced DLCO (OR 3.01, p = 0.054).CONCLUSIONS: Functional limitations causing chronic morbidity in COVID-19 survivors persist over 12 months after SARS-CoV-2 infection. These limitations were particularly seen in parameters of overall performance and gas exchange resulting from muscular deconditioning and lung parenchymal changes. Patient reported reduced respiratory quality of life was a risk factor for adverse CPET performance.
KW - COVID-19/diagnosis
KW - Exercise Test/methods
KW - Exercise Tolerance
KW - Humans
KW - Oxygen
KW - Quality of Life
KW - SARS-CoV-2
KW - Severity of Illness Index
U2 - 10.1016/j.rmed.2022.106968
DO - 10.1016/j.rmed.2022.106968
M3 - SCORING: Journal article
C2 - 36081267
VL - 202
JO - RESP MED
JF - RESP MED
SN - 0954-6111
M1 - 106968
ER -
