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Functional iron deficiency and diastolic function in heart failure with preserved ejection fraction

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Functional iron deficiency and diastolic function in heart failure with preserved ejection fraction. / Kasner, Mario; Aleksandrov, Aleksandar S; Westermann, Dirk; Lassner, Dirk; Gross, Michael; von Haehling, Stephan; Anker, Stefan D; Schultheiss, Heinz-Peter; Tschöpe, Carsten.

in: INT J CARDIOL, Jahrgang 168, Nr. 5, 12.10.2013, S. 4652-4657.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Kasner, M, Aleksandrov, AS, Westermann, D, Lassner, D, Gross, M, von Haehling, S, Anker, SD, Schultheiss, H-P & Tschöpe, C 2013, 'Functional iron deficiency and diastolic function in heart failure with preserved ejection fraction', INT J CARDIOL, Jg. 168, Nr. 5, S. 4652-4657. https://doi.org/10.1016/j.ijcard.2013.07.185

APA

Kasner, M., Aleksandrov, A. S., Westermann, D., Lassner, D., Gross, M., von Haehling, S., Anker, S. D., Schultheiss, H-P., & Tschöpe, C. (2013). Functional iron deficiency and diastolic function in heart failure with preserved ejection fraction. INT J CARDIOL, 168(5), 4652-4657. https://doi.org/10.1016/j.ijcard.2013.07.185

Vancouver

Kasner M, Aleksandrov AS, Westermann D, Lassner D, Gross M, von Haehling S et al. Functional iron deficiency and diastolic function in heart failure with preserved ejection fraction. INT J CARDIOL. 2013 Okt 12;168(5):4652-4657. https://doi.org/10.1016/j.ijcard.2013.07.185

Bibtex

@article{eb6e21a808e2486aa4f08611375cbd72,
title = "Functional iron deficiency and diastolic function in heart failure with preserved ejection fraction",
abstract = "BACKGROUND: Functional iron deficiency (FID) is an independent risk factor for poor outcome in advanced heart failure with reduced EF, but its role in heart failure with preserved EF (HFPEF) remains unclear. We aimed to investigate the impact of FID on cardiac performance determined by pressure-volume loop analysis in HFPEF.METHODS: 26 HFPEF patients who showed an increase in LV stiffness by pressure-volume (PV) loop analysis obtained by conductance-catheterization, performed exercise testing, echocardiographic examination including tissue Doppler and determination of iron metabolism: serum iron, ferritin and transferrin saturation. HFPEF patients who provided ferritin <100 μg/l or ferritin of 100-299 μg/l in combination with transferrin saturation <20% were defined as having FID. In 14 patients the expression of transferrin receptor was determined from available endomyocardial biopsies.RESULTS: Fifteen out of 26 HFPEF patients showed FID without anemia. Compared to control subjects and HFPEF patients without FID, HFPEF patients with FID showed an up-regulation of the myocardial transferrin receptor expression (p<0.05). No differences between HFPEF patients with and without iron deficiency were found in heart dimensions, systolic and diastolic function obtained by PV-loop and echocardiography analysis. According to the linear regression analysis, LV stiffness was correlated with peak oxygen uptake (r=-0.636, p<0.001) but not with the ferritin level or transferrin saturation. No relation was found between FID and exercise capacity. The association of LV stiffness with exercise performance was independent from the level of iron deficiency.CONCLUSION: In non-anemic HFPEF patients, cardiac dysfunction and impaired exercise capacity occur independently of FID.",
keywords = "Biomarkers/blood, Cardiac Catheterization, Diastole, Echocardiography, Exercise Tolerance, Follow-Up Studies, Heart Failure/blood, Iron/blood, Risk Factors, Stroke Volume/physiology, Ventricular Function, Left, Ventricular Pressure",
author = "Mario Kasner and Aleksandrov, {Aleksandar S} and Dirk Westermann and Dirk Lassner and Michael Gross and {von Haehling}, Stephan and Anker, {Stefan D} and Heinz-Peter Schultheiss and Carsten Tsch{\"o}pe",
note = "{\textcopyright} 2013.",
year = "2013",
month = oct,
day = "12",
doi = "10.1016/j.ijcard.2013.07.185",
language = "English",
volume = "168",
pages = "4652--4657",
journal = "INT J CARDIOL",
issn = "0167-5273",
publisher = "Elsevier Ireland Ltd",
number = "5",

}

RIS

TY - JOUR

T1 - Functional iron deficiency and diastolic function in heart failure with preserved ejection fraction

AU - Kasner, Mario

AU - Aleksandrov, Aleksandar S

AU - Westermann, Dirk

AU - Lassner, Dirk

AU - Gross, Michael

AU - von Haehling, Stephan

AU - Anker, Stefan D

AU - Schultheiss, Heinz-Peter

AU - Tschöpe, Carsten

N1 - © 2013.

PY - 2013/10/12

Y1 - 2013/10/12

N2 - BACKGROUND: Functional iron deficiency (FID) is an independent risk factor for poor outcome in advanced heart failure with reduced EF, but its role in heart failure with preserved EF (HFPEF) remains unclear. We aimed to investigate the impact of FID on cardiac performance determined by pressure-volume loop analysis in HFPEF.METHODS: 26 HFPEF patients who showed an increase in LV stiffness by pressure-volume (PV) loop analysis obtained by conductance-catheterization, performed exercise testing, echocardiographic examination including tissue Doppler and determination of iron metabolism: serum iron, ferritin and transferrin saturation. HFPEF patients who provided ferritin <100 μg/l or ferritin of 100-299 μg/l in combination with transferrin saturation <20% were defined as having FID. In 14 patients the expression of transferrin receptor was determined from available endomyocardial biopsies.RESULTS: Fifteen out of 26 HFPEF patients showed FID without anemia. Compared to control subjects and HFPEF patients without FID, HFPEF patients with FID showed an up-regulation of the myocardial transferrin receptor expression (p<0.05). No differences between HFPEF patients with and without iron deficiency were found in heart dimensions, systolic and diastolic function obtained by PV-loop and echocardiography analysis. According to the linear regression analysis, LV stiffness was correlated with peak oxygen uptake (r=-0.636, p<0.001) but not with the ferritin level or transferrin saturation. No relation was found between FID and exercise capacity. The association of LV stiffness with exercise performance was independent from the level of iron deficiency.CONCLUSION: In non-anemic HFPEF patients, cardiac dysfunction and impaired exercise capacity occur independently of FID.

AB - BACKGROUND: Functional iron deficiency (FID) is an independent risk factor for poor outcome in advanced heart failure with reduced EF, but its role in heart failure with preserved EF (HFPEF) remains unclear. We aimed to investigate the impact of FID on cardiac performance determined by pressure-volume loop analysis in HFPEF.METHODS: 26 HFPEF patients who showed an increase in LV stiffness by pressure-volume (PV) loop analysis obtained by conductance-catheterization, performed exercise testing, echocardiographic examination including tissue Doppler and determination of iron metabolism: serum iron, ferritin and transferrin saturation. HFPEF patients who provided ferritin <100 μg/l or ferritin of 100-299 μg/l in combination with transferrin saturation <20% were defined as having FID. In 14 patients the expression of transferrin receptor was determined from available endomyocardial biopsies.RESULTS: Fifteen out of 26 HFPEF patients showed FID without anemia. Compared to control subjects and HFPEF patients without FID, HFPEF patients with FID showed an up-regulation of the myocardial transferrin receptor expression (p<0.05). No differences between HFPEF patients with and without iron deficiency were found in heart dimensions, systolic and diastolic function obtained by PV-loop and echocardiography analysis. According to the linear regression analysis, LV stiffness was correlated with peak oxygen uptake (r=-0.636, p<0.001) but not with the ferritin level or transferrin saturation. No relation was found between FID and exercise capacity. The association of LV stiffness with exercise performance was independent from the level of iron deficiency.CONCLUSION: In non-anemic HFPEF patients, cardiac dysfunction and impaired exercise capacity occur independently of FID.

KW - Biomarkers/blood

KW - Cardiac Catheterization

KW - Diastole

KW - Echocardiography

KW - Exercise Tolerance

KW - Follow-Up Studies

KW - Heart Failure/blood

KW - Iron/blood

KW - Risk Factors

KW - Stroke Volume/physiology

KW - Ventricular Function, Left

KW - Ventricular Pressure

U2 - 10.1016/j.ijcard.2013.07.185

DO - 10.1016/j.ijcard.2013.07.185

M3 - SCORING: Journal article

C2 - 23968714

VL - 168

SP - 4652

EP - 4657

JO - INT J CARDIOL

JF - INT J CARDIOL

SN - 0167-5273

IS - 5

ER -