Functional heterogeneity of CD4+ T cells in liver inflammation
Beteiligte Einrichtungen
Abstract
CD4+ T cells play an essential role in orchestrating adequate immunity, but their overactivity has been associated with the development of immune-mediated inflammatory diseases, including liver inflammatory diseases. These cells can be subclassified according to their maturation stage, cytokine profile, and pro or anti-inflammatory functions, i.e., functional heterogeneity. In this review, we summarize what has been discovered so far regarding the role of the different CD4+ T cell polarization states in the progression of two prominent and still different liver inflammatory diseases: non-alcoholic steatohepatitis (NASH) and autoimmune hepatitis (AIH). Finally, the potential of CD4+ T cells as a therapeutic target in both NASH and AIH is discussed.
Bibliografische Daten
Originalsprache | Englisch |
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ISSN | 1863-2297 |
DOIs | |
Status | Veröffentlicht - 08.2021 |
Anmerkungen des Dekanats
© 2021. The Author(s).
PubMed | 34463867 |
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