Functional expression and cellular mRNA localization of a G protein-activated K+ inward rectifier isolated from rat brain.
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Functional expression and cellular mRNA localization of a G protein-activated K+ inward rectifier isolated from rat brain. / Dissmann, E; Wischmeyer, E; Spauschus, Alexander; Pfeil, D V; Karschin, C; Karschin, A.
in: BIOCHEM BIOPH RES CO, Jahrgang 223, Nr. 2, 2, 1996, S. 474-479.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Functional expression and cellular mRNA localization of a G protein-activated K+ inward rectifier isolated from rat brain.
AU - Dissmann, E
AU - Wischmeyer, E
AU - Spauschus, Alexander
AU - Pfeil, D V
AU - Karschin, C
AU - Karschin, A
PY - 1996
Y1 - 1996
N2 - We have cloned by homology screening from a rat brain cDNA library a GIRK3-type (Kir 3.3) inwardly rectifying K+ channel subunit with high structural similarity to other subfamily members whose activity is thought to be controlled by receptor-stimulated G proteins. When heterologously expressed both in Xenopus oocytes and in mammalian COS-7 cells, rbGIRK3 subunits individually fail to form functional channels. In contrast, when coexpressed with other GIRK subunits, rbGIRK3 gives rise to prominent currents which are enhanced by the stimulation of coexpressed 5-HT1A receptors. In situ hybridizations show that of all GIRK subunits rbGIRK3 is most widely distributed and strongly expressed throughout the rat brain and thus may play an important role in central signal processing.
AB - We have cloned by homology screening from a rat brain cDNA library a GIRK3-type (Kir 3.3) inwardly rectifying K+ channel subunit with high structural similarity to other subfamily members whose activity is thought to be controlled by receptor-stimulated G proteins. When heterologously expressed both in Xenopus oocytes and in mammalian COS-7 cells, rbGIRK3 subunits individually fail to form functional channels. In contrast, when coexpressed with other GIRK subunits, rbGIRK3 gives rise to prominent currents which are enhanced by the stimulation of coexpressed 5-HT1A receptors. In situ hybridizations show that of all GIRK subunits rbGIRK3 is most widely distributed and strongly expressed throughout the rat brain and thus may play an important role in central signal processing.
M3 - SCORING: Zeitschriftenaufsatz
VL - 223
SP - 474
EP - 479
JO - BIOCHEM BIOPH RES CO
JF - BIOCHEM BIOPH RES CO
SN - 0006-291X
IS - 2
M1 - 2
ER -
