PortalPublikationenFunctional and oncological outcomes of patients aged < 50 ye...

Functional and oncological outcomes of patients aged < 50 years treated with radical prostatectomy for localised prostate cancer in a European population

Standard

Functional and oncological outcomes of patients aged < 50 years treated with radical prostatectomy for localised prostate cancer in a European population. / Becker, Andreas; Tennstedt, Pierre; Hansen, Jens; Trinh, Quoc-Dien; Kluth, Luis; Atassi, Nabil; Schlomm, Thorsten; Salomon, Georg; Haese, Alexander; Budaeus, Lars; Michl, Uwe; Heinzer, Hans; Huland, Hartwig; Graefen, Markus; Steuber, Thomas.

in: BJU INT, Jahrgang 114, Nr. 1, 06.2014, S. 38-45.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Becker, A, Tennstedt, P, Hansen, J, Trinh, Q-D, Kluth, L, Atassi, N, Schlomm, T, Salomon, G, Haese, A, Budaeus, L, Michl, U, Heinzer, H, Huland, H, Graefen, M & Steuber, T 2014, 'Functional and oncological outcomes of patients aged < 50 years treated with radical prostatectomy for localised prostate cancer in a European population', BJU INT, Jg. 114, Nr. 1, S. 38-45. https://doi.org/10.1111/bju.12407

APA

Becker, A., Tennstedt, P., Hansen, J., Trinh, Q-D., Kluth, L., Atassi, N., Schlomm, T., Salomon, G., Haese, A., Budaeus, L., Michl, U., Heinzer, H., Huland, H., Graefen, M., & Steuber, T. (2014). Functional and oncological outcomes of patients aged < 50 years treated with radical prostatectomy for localised prostate cancer in a European population. BJU INT, 114(1), 38-45. https://doi.org/10.1111/bju.12407

Vancouver

Becker A, Tennstedt P, Hansen J, Trinh Q-D, Kluth L, Atassi N et al. Functional and oncological outcomes of patients aged < 50 years treated with radical prostatectomy for localised prostate cancer in a European population. BJU INT. 2014 Jun;114(1):38-45. https://doi.org/10.1111/bju.12407

Bibtex

@article{dcd1c9a81989414fbb9b014f84ff0212,
title = "Functional and oncological outcomes of patients aged < 50 years treated with radical prostatectomy for localised prostate cancer in a European population",
abstract = "OBJECTIVE: To address the biochemical and functional outcomes after radical prostatectomy (RP) of men aged <50 years in a large European population.PATIENTS AND METHODS: Among 13 268 patients who underwent RP for clinically localised prostate cancer at our centre (1992-2011), 443 (3.3%) men aged <50 were identified. Biochemical recurrence (BCR) and functional outcomes (International Index of Erectile Function [IIEF-5], use of pads), were prospectively evaluated and compared between men aged <50 years and older patients.RESULTS: Men aged <50 years were more likely to harbour D'Amico low-risk (49.4 vs 34.9%, P < 0.001), organ-confined (82.6 vs 69.4%, P < 0.001) and low-grade tumours (Gleason score <7: 33.1 vs 28.7%, P < 0.001). Multivariate Cox regression analysis showed that age <50 years (hazard ratio 0.99; confidence interval 0.72-1.31; P = 0.9) was not a predictor of BCR. Urinary continence was more favourable in younger patients, resulting in continence rates of 97.4% vs 91.6% in most recent years (2009-2011) for patients aged <50 vs ≥50 years. After RP, a median IIEF-5 drop of 4 points in younger men vs 8 points in older patients was recorded (P < 0.001). Favourable recovery of urinary continence and erectile function in patients aged <50 years compared with their older counterparts was confirmed after multivariable adjustment.CONCLUSION: Men aged <50 years diagnosed with localised prostate cancer should not be discouraged from RP, as the postoperative rates of urinary incontinence and erectile dysfunction are low and probability of BCR-free survival at 2 and 5 years is high.",
author = "Andreas Becker and Pierre Tennstedt and Jens Hansen and Quoc-Dien Trinh and Luis Kluth and Nabil Atassi and Thorsten Schlomm and Georg Salomon and Alexander Haese and Lars Budaeus and Uwe Michl and Hans Heinzer and Hartwig Huland and Markus Graefen and Thomas Steuber",
note = "{\textcopyright} 2013 The Authors. BJU International {\textcopyright} 2013 BJU International.",
year = "2014",
month = jun,
doi = "10.1111/bju.12407",
language = "English",
volume = "114",
pages = "38--45",
journal = "BJU INT",
issn = "1464-4096",
publisher = "Wiley-Blackwell",
number = "1",

}

RIS

TY - JOUR

T1 - Functional and oncological outcomes of patients aged < 50 years treated with radical prostatectomy for localised prostate cancer in a European population

AU - Becker, Andreas

AU - Tennstedt, Pierre

AU - Hansen, Jens

AU - Trinh, Quoc-Dien

AU - Kluth, Luis

AU - Atassi, Nabil

AU - Schlomm, Thorsten

AU - Salomon, Georg

AU - Haese, Alexander

AU - Budaeus, Lars

AU - Michl, Uwe

AU - Heinzer, Hans

AU - Huland, Hartwig

AU - Graefen, Markus

AU - Steuber, Thomas

N1 - © 2013 The Authors. BJU International © 2013 BJU International.

PY - 2014/6

Y1 - 2014/6

N2 - OBJECTIVE: To address the biochemical and functional outcomes after radical prostatectomy (RP) of men aged <50 years in a large European population.PATIENTS AND METHODS: Among 13 268 patients who underwent RP for clinically localised prostate cancer at our centre (1992-2011), 443 (3.3%) men aged <50 were identified. Biochemical recurrence (BCR) and functional outcomes (International Index of Erectile Function [IIEF-5], use of pads), were prospectively evaluated and compared between men aged <50 years and older patients.RESULTS: Men aged <50 years were more likely to harbour D'Amico low-risk (49.4 vs 34.9%, P < 0.001), organ-confined (82.6 vs 69.4%, P < 0.001) and low-grade tumours (Gleason score <7: 33.1 vs 28.7%, P < 0.001). Multivariate Cox regression analysis showed that age <50 years (hazard ratio 0.99; confidence interval 0.72-1.31; P = 0.9) was not a predictor of BCR. Urinary continence was more favourable in younger patients, resulting in continence rates of 97.4% vs 91.6% in most recent years (2009-2011) for patients aged <50 vs ≥50 years. After RP, a median IIEF-5 drop of 4 points in younger men vs 8 points in older patients was recorded (P < 0.001). Favourable recovery of urinary continence and erectile function in patients aged <50 years compared with their older counterparts was confirmed after multivariable adjustment.CONCLUSION: Men aged <50 years diagnosed with localised prostate cancer should not be discouraged from RP, as the postoperative rates of urinary incontinence and erectile dysfunction are low and probability of BCR-free survival at 2 and 5 years is high.

AB - OBJECTIVE: To address the biochemical and functional outcomes after radical prostatectomy (RP) of men aged <50 years in a large European population.PATIENTS AND METHODS: Among 13 268 patients who underwent RP for clinically localised prostate cancer at our centre (1992-2011), 443 (3.3%) men aged <50 were identified. Biochemical recurrence (BCR) and functional outcomes (International Index of Erectile Function [IIEF-5], use of pads), were prospectively evaluated and compared between men aged <50 years and older patients.RESULTS: Men aged <50 years were more likely to harbour D'Amico low-risk (49.4 vs 34.9%, P < 0.001), organ-confined (82.6 vs 69.4%, P < 0.001) and low-grade tumours (Gleason score <7: 33.1 vs 28.7%, P < 0.001). Multivariate Cox regression analysis showed that age <50 years (hazard ratio 0.99; confidence interval 0.72-1.31; P = 0.9) was not a predictor of BCR. Urinary continence was more favourable in younger patients, resulting in continence rates of 97.4% vs 91.6% in most recent years (2009-2011) for patients aged <50 vs ≥50 years. After RP, a median IIEF-5 drop of 4 points in younger men vs 8 points in older patients was recorded (P < 0.001). Favourable recovery of urinary continence and erectile function in patients aged <50 years compared with their older counterparts was confirmed after multivariable adjustment.CONCLUSION: Men aged <50 years diagnosed with localised prostate cancer should not be discouraged from RP, as the postoperative rates of urinary incontinence and erectile dysfunction are low and probability of BCR-free survival at 2 and 5 years is high.

U2 - 10.1111/bju.12407

DO - 10.1111/bju.12407

M3 - SCORING: Journal article

C2 - 24053677

VL - 114

SP - 38

EP - 45

JO - BJU INT

JF - BJU INT

SN - 1464-4096

IS - 1

ER -