Functional analysis of circulating tumour cells: the KEY to understand the biology of the metastatic cascade

Zahra Eslami-S; Luis Enrique Cortés-Hernández; Frédéric Thomas; Klaus Pantel; Catherine Alix-Panabières

doi:10.1038/s41416-022-01819-1

Functional analysis of circulating tumour cells: the KEY to understand the biology of the metastatic cascade

Standard

Functional analysis of circulating tumour cells: the KEY to understand the biology of the metastatic cascade. / Eslami-S, Zahra; Cortés-Hernández, Luis Enrique; Thomas, Frédéric; Pantel, Klaus; Alix-Panabières, Catherine.

in: BRIT J CANCER, Jahrgang 127, Nr. 5, 09.2022, S. 800-810.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Eslami-S, Z, Cortés-Hernández, LE, Thomas, F, Pantel, K & Alix-Panabières, C 2022, 'Functional analysis of circulating tumour cells: the KEY to understand the biology of the metastatic cascade', BRIT J CANCER, Jg. 127, Nr. 5, S. 800-810. https://doi.org/10.1038/s41416-022-01819-1

APA

Eslami-S, Z., Cortés-Hernández, L. E., Thomas, F., Pantel, K., & Alix-Panabières, C. (2022). Functional analysis of circulating tumour cells: the KEY to understand the biology of the metastatic cascade. BRIT J CANCER, 127(5), 800-810. https://doi.org/10.1038/s41416-022-01819-1

Vancouver

Eslami-S Z, Cortés-Hernández LE, Thomas F, Pantel K, Alix-Panabières C. Functional analysis of circulating tumour cells: the KEY to understand the biology of the metastatic cascade. BRIT J CANCER. 2022 Sep;127(5):800-810. https://doi.org/10.1038/s41416-022-01819-1

Bibtex

@article{29055c212c9b4e2ab27b77892a7443f2,

title = "Functional analysis of circulating tumour cells: the KEY to understand the biology of the metastatic cascade",

abstract = "Metastasis formation is the main cause of cancer-related death in patients with solid tumours. At the beginning of this process, cancer cells escape from the primary tumour to the blood circulation where they become circulating tumour cells (CTCs). Only a small subgroup of CTCs will survive during the harsh journey in the blood and colonise distant sites. The in-depth analysis of these metastasis-competent CTCs is very challenging because of their extremely low concentration in peripheral blood. So far, only few groups managed to expand in vitro and in vivo CTCs to be used as models for large-scale descriptive and functional analyses of CTCs. These models have shown already the high variability and complexity of the metastatic cascade in patients with cancer, and open a new avenue for the development of new diagnostic and therapeutic approaches.",

author = "Zahra Eslami-S and Cort{\'e}s-Hern{\'a}ndez, {Luis Enrique} and Fr{\'e}d{\'e}ric Thomas and Klaus Pantel and Catherine Alix-Panabi{\`e}res",

note = "{\textcopyright} 2022. The Author(s).",

year = "2022",

month = sep,

doi = "10.1038/s41416-022-01819-1",

language = "English",

volume = "127",

pages = "800--810",

journal = "BRIT J CANCER",

issn = "0007-0920",

publisher = "NATURE PUBLISHING GROUP",

number = "5",

}

RIS

TY - JOUR

T1 - Functional analysis of circulating tumour cells: the KEY to understand the biology of the metastatic cascade

AU - Eslami-S, Zahra

AU - Cortés-Hernández, Luis Enrique

AU - Thomas, Frédéric

AU - Pantel, Klaus

AU - Alix-Panabières, Catherine

PY - 2022/9

Y1 - 2022/9

N2 - Metastasis formation is the main cause of cancer-related death in patients with solid tumours. At the beginning of this process, cancer cells escape from the primary tumour to the blood circulation where they become circulating tumour cells (CTCs). Only a small subgroup of CTCs will survive during the harsh journey in the blood and colonise distant sites. The in-depth analysis of these metastasis-competent CTCs is very challenging because of their extremely low concentration in peripheral blood. So far, only few groups managed to expand in vitro and in vivo CTCs to be used as models for large-scale descriptive and functional analyses of CTCs. These models have shown already the high variability and complexity of the metastatic cascade in patients with cancer, and open a new avenue for the development of new diagnostic and therapeutic approaches.

AB - Metastasis formation is the main cause of cancer-related death in patients with solid tumours. At the beginning of this process, cancer cells escape from the primary tumour to the blood circulation where they become circulating tumour cells (CTCs). Only a small subgroup of CTCs will survive during the harsh journey in the blood and colonise distant sites. The in-depth analysis of these metastasis-competent CTCs is very challenging because of their extremely low concentration in peripheral blood. So far, only few groups managed to expand in vitro and in vivo CTCs to be used as models for large-scale descriptive and functional analyses of CTCs. These models have shown already the high variability and complexity of the metastatic cascade in patients with cancer, and open a new avenue for the development of new diagnostic and therapeutic approaches.

U2 - 10.1038/s41416-022-01819-1

DO - 10.1038/s41416-022-01819-1

M3 - SCORING: Review article

C2 - 35484215

VL - 127

SP - 800

EP - 810

JO - BRIT J CANCER

JF - BRIT J CANCER

SN - 0007-0920

IS - 5

ER -