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Frontal glutamate and reward processing in adolescence and adulthood

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Frontal glutamate and reward processing in adolescence and adulthood. / Gleich, Tobias; Lorenz, Robert C; Pöhland, Lydia; Raufelder, Diana; Deserno, Lorenz; Beck, Anne; Heinz, Andreas; Kühn, Simone; Gallinat, Jürgen.

in: BRAIN STRUCT FUNCT, Jahrgang 220, Nr. 6, 11.2015, S. 3087-99.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Gleich, T, Lorenz, RC, Pöhland, L, Raufelder, D, Deserno, L, Beck, A, Heinz, A, Kühn, S & Gallinat, J 2015, 'Frontal glutamate and reward processing in adolescence and adulthood', BRAIN STRUCT FUNCT, Jg. 220, Nr. 6, S. 3087-99. https://doi.org/10.1007/s00429-014-0844-3

APA

Gleich, T., Lorenz, R. C., Pöhland, L., Raufelder, D., Deserno, L., Beck, A., Heinz, A., Kühn, S., & Gallinat, J. (2015). Frontal glutamate and reward processing in adolescence and adulthood. BRAIN STRUCT FUNCT, 220(6), 3087-99. https://doi.org/10.1007/s00429-014-0844-3

Vancouver

Gleich T, Lorenz RC, Pöhland L, Raufelder D, Deserno L, Beck A et al. Frontal glutamate and reward processing in adolescence and adulthood. BRAIN STRUCT FUNCT. 2015 Nov;220(6):3087-99. https://doi.org/10.1007/s00429-014-0844-3

Bibtex

@article{718ee32b4d89448d9a0c9c13c5b4d316,
title = "Frontal glutamate and reward processing in adolescence and adulthood",
abstract = "The fronto-limbic network interaction, driven by glutamatergic and dopaminergic neurotransmission, represents a core mechanism of motivated behavior and personality traits. Reward seeking behavior undergoes tremendous changes in adolescence paralleled by neurobiological changes of this network including the prefrontal cortex, striatum and amygdala. Since fronto-limbic dysfunctions also underlie major psychiatric diseases beginning in adolescence, this investigation focuses on network characteristics separating adolescents from adults. To investigate differences in network interactions, the brain reward system activity (slot machine task) together with frontal glutamate concentration (anterior cingulate cortex, ACC) was measured in 28 adolescents and 26 adults employing functional magnetic resonance imaging and magnetic resonance spectroscopy, respectively. An inverse coupling of glutamate concentrations in the ACC and activation of the ventral striatum was observed in adolescents. Further, amygdala response in adolescents was negatively correlated with the personality trait impulsivity. For adults, no significant associations of network components or correlations with impulsivity were found. The inverse association between frontal glutamate concentration and striatal activation in adolescents is in line with the triadic model of motivated behavior stressing the important role of frontal top-down inhibition on limbic structures. Our data identified glutamate as the mediating neurotransmitter of this inhibitory process and demonstrates the relevance of glutamate on the reward system and related behavioral traits like impulsivity. This fronto-limbic coupling may represent a vulnerability factor for psychiatric disorders starting in adolescence but not in adulthood.",
author = "Tobias Gleich and Lorenz, {Robert C} and Lydia P{\"o}hland and Diana Raufelder and Lorenz Deserno and Anne Beck and Andreas Heinz and Simone K{\"u}hn and J{\"u}rgen Gallinat",
year = "2015",
month = nov,
doi = "10.1007/s00429-014-0844-3",
language = "English",
volume = "220",
pages = "3087--99",
journal = "BRAIN STRUCT FUNCT",
issn = "1863-2653",
publisher = "Springer",
number = "6",

}

RIS

TY - JOUR

T1 - Frontal glutamate and reward processing in adolescence and adulthood

AU - Gleich, Tobias

AU - Lorenz, Robert C

AU - Pöhland, Lydia

AU - Raufelder, Diana

AU - Deserno, Lorenz

AU - Beck, Anne

AU - Heinz, Andreas

AU - Kühn, Simone

AU - Gallinat, Jürgen

PY - 2015/11

Y1 - 2015/11

N2 - The fronto-limbic network interaction, driven by glutamatergic and dopaminergic neurotransmission, represents a core mechanism of motivated behavior and personality traits. Reward seeking behavior undergoes tremendous changes in adolescence paralleled by neurobiological changes of this network including the prefrontal cortex, striatum and amygdala. Since fronto-limbic dysfunctions also underlie major psychiatric diseases beginning in adolescence, this investigation focuses on network characteristics separating adolescents from adults. To investigate differences in network interactions, the brain reward system activity (slot machine task) together with frontal glutamate concentration (anterior cingulate cortex, ACC) was measured in 28 adolescents and 26 adults employing functional magnetic resonance imaging and magnetic resonance spectroscopy, respectively. An inverse coupling of glutamate concentrations in the ACC and activation of the ventral striatum was observed in adolescents. Further, amygdala response in adolescents was negatively correlated with the personality trait impulsivity. For adults, no significant associations of network components or correlations with impulsivity were found. The inverse association between frontal glutamate concentration and striatal activation in adolescents is in line with the triadic model of motivated behavior stressing the important role of frontal top-down inhibition on limbic structures. Our data identified glutamate as the mediating neurotransmitter of this inhibitory process and demonstrates the relevance of glutamate on the reward system and related behavioral traits like impulsivity. This fronto-limbic coupling may represent a vulnerability factor for psychiatric disorders starting in adolescence but not in adulthood.

AB - The fronto-limbic network interaction, driven by glutamatergic and dopaminergic neurotransmission, represents a core mechanism of motivated behavior and personality traits. Reward seeking behavior undergoes tremendous changes in adolescence paralleled by neurobiological changes of this network including the prefrontal cortex, striatum and amygdala. Since fronto-limbic dysfunctions also underlie major psychiatric diseases beginning in adolescence, this investigation focuses on network characteristics separating adolescents from adults. To investigate differences in network interactions, the brain reward system activity (slot machine task) together with frontal glutamate concentration (anterior cingulate cortex, ACC) was measured in 28 adolescents and 26 adults employing functional magnetic resonance imaging and magnetic resonance spectroscopy, respectively. An inverse coupling of glutamate concentrations in the ACC and activation of the ventral striatum was observed in adolescents. Further, amygdala response in adolescents was negatively correlated with the personality trait impulsivity. For adults, no significant associations of network components or correlations with impulsivity were found. The inverse association between frontal glutamate concentration and striatal activation in adolescents is in line with the triadic model of motivated behavior stressing the important role of frontal top-down inhibition on limbic structures. Our data identified glutamate as the mediating neurotransmitter of this inhibitory process and demonstrates the relevance of glutamate on the reward system and related behavioral traits like impulsivity. This fronto-limbic coupling may represent a vulnerability factor for psychiatric disorders starting in adolescence but not in adulthood.

U2 - 10.1007/s00429-014-0844-3

DO - 10.1007/s00429-014-0844-3

M3 - SCORING: Journal article

C2 - 25009315

VL - 220

SP - 3087

EP - 3099

JO - BRAIN STRUCT FUNCT

JF - BRAIN STRUCT FUNCT

SN - 1863-2653

IS - 6

ER -