Frequency specific interactions of MEG resting state activity within and across brain networks as revealed by the multivariate interaction measure

TY - JOUR

T1 - Frequency specific interactions of MEG resting state activity within and across brain networks as revealed by the multivariate interaction measure

AU - Marzetti, L

AU - Della Penna, S

AU - Snyder, A Z

AU - Pizzella, V

AU - Nolte, G

AU - de Pasquale, F

AU - Romani, G L

AU - Corbetta, M

N1 - Copyright © 2013 Elsevier Inc. All rights reserved.

PY - 2013/10/1

Y1 - 2013/10/1

N2 - Resting state networks (RSNs) are sets of brain regions exhibiting temporally coherent activity fluctuations in the absence of imposed task structure. RSNs have been extensively studied with fMRI in the infra-slow frequency range (nominally <10(-1)Hz). The topography of fMRI RSNs reflects stationary temporal correlation over minutes. However, neuronal communication occurs on a much faster time scale, at frequencies nominally in the range of 10(0)-10(2)Hz. We examined phase-shifted interactions in the delta (2-3.5 Hz), theta (4-7 Hz), alpha (8-12 Hz) and beta (13-30 Hz) frequency bands of resting-state source space MEG signals. These analyses were conducted between nodes of the dorsal attention network (DAN), one of the most robust RSNs, and between the DAN and other networks. Phase shifted interactions were mapped by the multivariate interaction measure (MIM), a measure of true interaction constructed from the maximization of imaginary coherency in the virtual channels comprised of voxel signals in source space. Non-zero-phase interactions occurred between homologous left and right hemisphere regions of the DAN in the delta and alpha frequency bands. Even stronger non-zero-phase interactions were detected between networks. Visual regions bilaterally showed phase-shifted interactions in the alpha band with regions of the DAN. Bilateral somatomotor regions interacted with DAN nodes in the beta band. These results demonstrate the existence of consistent, frequency specific phase-shifted interactions on a millisecond time scale between cortical regions within RSN as well as across RSNs.

AB - Resting state networks (RSNs) are sets of brain regions exhibiting temporally coherent activity fluctuations in the absence of imposed task structure. RSNs have been extensively studied with fMRI in the infra-slow frequency range (nominally <10(-1)Hz). The topography of fMRI RSNs reflects stationary temporal correlation over minutes. However, neuronal communication occurs on a much faster time scale, at frequencies nominally in the range of 10(0)-10(2)Hz. We examined phase-shifted interactions in the delta (2-3.5 Hz), theta (4-7 Hz), alpha (8-12 Hz) and beta (13-30 Hz) frequency bands of resting-state source space MEG signals. These analyses were conducted between nodes of the dorsal attention network (DAN), one of the most robust RSNs, and between the DAN and other networks. Phase shifted interactions were mapped by the multivariate interaction measure (MIM), a measure of true interaction constructed from the maximization of imaginary coherency in the virtual channels comprised of voxel signals in source space. Non-zero-phase interactions occurred between homologous left and right hemisphere regions of the DAN in the delta and alpha frequency bands. Even stronger non-zero-phase interactions were detected between networks. Visual regions bilaterally showed phase-shifted interactions in the alpha band with regions of the DAN. Bilateral somatomotor regions interacted with DAN nodes in the beta band. These results demonstrate the existence of consistent, frequency specific phase-shifted interactions on a millisecond time scale between cortical regions within RSN as well as across RSNs.

KW - Adult

KW - Brain

KW - Brain Mapping

KW - Computer Simulation

KW - Female

KW - Humans

KW - Magnetoencephalography

KW - Male

KW - Models, Neurological

KW - Models, Statistical

KW - Multivariate Analysis

KW - Nerve Net

KW - Rest

U2 - 10.1016/j.neuroimage.2013.04.062

DO - 10.1016/j.neuroimage.2013.04.062

M3 - SCORING: Journal article

C2 - 23631996

VL - 79

SP - 172

EP - 183

JO - NEUROIMAGE

JF - NEUROIMAGE

SN - 1053-8119

ER -