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FoxO transcription factors are required for hepatic HDL-cholesterol clearance

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FoxO transcription factors are required for hepatic HDL-cholesterol clearance. / Lee, Samuel X; Heine, Markus; Schlein, Christian; Ramakrishnan, Rajasekhar; Liu, Jing; Belnavis, Gabriella; Haimi, Ido; Fischer, Alexander W; Ginsberg, Henry; Heeren, Joerg; Rinninger, Franz; Haeusler, Rebecca A.

in: J CLIN INVEST, Jahrgang 128, Nr. 4, 02.04.2018, S. 1615-1626.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Lee, SX, Heine, M, Schlein, C, Ramakrishnan, R, Liu, J, Belnavis, G, Haimi, I, Fischer, AW, Ginsberg, H, Heeren, J, Rinninger, F & Haeusler, RA 2018, 'FoxO transcription factors are required for hepatic HDL-cholesterol clearance', J CLIN INVEST, Jg. 128, Nr. 4, S. 1615-1626. https://doi.org/10.1172/JCI94230

APA

Lee, S. X., Heine, M., Schlein, C., Ramakrishnan, R., Liu, J., Belnavis, G., Haimi, I., Fischer, A. W., Ginsberg, H., Heeren, J., Rinninger, F., & Haeusler, R. A. (2018). FoxO transcription factors are required for hepatic HDL-cholesterol clearance. J CLIN INVEST, 128(4), 1615-1626. https://doi.org/10.1172/JCI94230

Vancouver

Lee SX, Heine M, Schlein C, Ramakrishnan R, Liu J, Belnavis G et al. FoxO transcription factors are required for hepatic HDL-cholesterol clearance. J CLIN INVEST. 2018 Apr 2;128(4):1615-1626. https://doi.org/10.1172/JCI94230

Bibtex

@article{df44d8366b634251be9cd8e2e960d613,
title = "FoxO transcription factors are required for hepatic HDL-cholesterol clearance",
abstract = "Insulin resistance and type 2 diabetes are associated with low levels of high-density lipoprotein cholesterol (HDL-C). The insulin-repressible FoxO transcription factors are potential mediators of the effect of insulin on HDL-C. FoxOs mediate a substantial portion of insulin-regulated transcription, and poor FoxO repression is thought to contribute to the excessive glucose production in diabetes. In this work, we show that mice with liver-specific triple FoxO knockout (L-FoxO1,3,4), which are known to have reduced hepatic glucose production, also have increased HDL-C. This was associated with decreased expression of the HDL-C clearance factors scavenger receptor class B type I (SR-BI) and hepatic lipase and defective selective uptake of HDL cholesteryl ester by the liver. The phenotype could be rescued by re-expression of SR-BI. These findings demonstrate that hepatic FoxOs are required for cholesterol homeostasis and HDL-mediated reverse cholesterol transport to the liver.",
keywords = "Journal Article",
author = "Lee, {Samuel X} and Markus Heine and Christian Schlein and Rajasekhar Ramakrishnan and Jing Liu and Gabriella Belnavis and Ido Haimi and Fischer, {Alexander W} and Henry Ginsberg and Joerg Heeren and Franz Rinninger and Haeusler, {Rebecca A}",
year = "2018",
month = apr,
day = "2",
doi = "10.1172/JCI94230",
language = "English",
volume = "128",
pages = "1615--1626",
journal = "J CLIN INVEST",
issn = "0021-9738",
publisher = "The American Society for Clinical Investigation",
number = "4",

}

RIS

TY - JOUR

T1 - FoxO transcription factors are required for hepatic HDL-cholesterol clearance

AU - Lee, Samuel X

AU - Heine, Markus

AU - Schlein, Christian

AU - Ramakrishnan, Rajasekhar

AU - Liu, Jing

AU - Belnavis, Gabriella

AU - Haimi, Ido

AU - Fischer, Alexander W

AU - Ginsberg, Henry

AU - Heeren, Joerg

AU - Rinninger, Franz

AU - Haeusler, Rebecca A

PY - 2018/4/2

Y1 - 2018/4/2

N2 - Insulin resistance and type 2 diabetes are associated with low levels of high-density lipoprotein cholesterol (HDL-C). The insulin-repressible FoxO transcription factors are potential mediators of the effect of insulin on HDL-C. FoxOs mediate a substantial portion of insulin-regulated transcription, and poor FoxO repression is thought to contribute to the excessive glucose production in diabetes. In this work, we show that mice with liver-specific triple FoxO knockout (L-FoxO1,3,4), which are known to have reduced hepatic glucose production, also have increased HDL-C. This was associated with decreased expression of the HDL-C clearance factors scavenger receptor class B type I (SR-BI) and hepatic lipase and defective selective uptake of HDL cholesteryl ester by the liver. The phenotype could be rescued by re-expression of SR-BI. These findings demonstrate that hepatic FoxOs are required for cholesterol homeostasis and HDL-mediated reverse cholesterol transport to the liver.

AB - Insulin resistance and type 2 diabetes are associated with low levels of high-density lipoprotein cholesterol (HDL-C). The insulin-repressible FoxO transcription factors are potential mediators of the effect of insulin on HDL-C. FoxOs mediate a substantial portion of insulin-regulated transcription, and poor FoxO repression is thought to contribute to the excessive glucose production in diabetes. In this work, we show that mice with liver-specific triple FoxO knockout (L-FoxO1,3,4), which are known to have reduced hepatic glucose production, also have increased HDL-C. This was associated with decreased expression of the HDL-C clearance factors scavenger receptor class B type I (SR-BI) and hepatic lipase and defective selective uptake of HDL cholesteryl ester by the liver. The phenotype could be rescued by re-expression of SR-BI. These findings demonstrate that hepatic FoxOs are required for cholesterol homeostasis and HDL-mediated reverse cholesterol transport to the liver.

KW - Journal Article

U2 - 10.1172/JCI94230

DO - 10.1172/JCI94230

M3 - SCORING: Journal article

C2 - 29408809

VL - 128

SP - 1615

EP - 1626

JO - J CLIN INVEST

JF - J CLIN INVEST

SN - 0021-9738

IS - 4

ER -