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Fluorescent Arc/Arg3.1 indicator mice: a versatile tool to study brain activity changes in vitro and in vivo.

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Fluorescent Arc/Arg3.1 indicator mice: a versatile tool to study brain activity changes in vitro and in vivo. / Grinevich, Valery; Kolleker, Alexander; Eliava, Marina; Takada, Naoki; Takuma, Hiroshi; Fukazawa, Yugo; Shigemoto, Ryuichi; Kuhl, Dietmar; Waters, Jack; Seeburg, Peter H; Osten, Pavel.

in: J NEUROSCI METH, Jahrgang 184, Nr. 1, 1, 2009, S. 25-36.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Grinevich, V, Kolleker, A, Eliava, M, Takada, N, Takuma, H, Fukazawa, Y, Shigemoto, R, Kuhl, D, Waters, J, Seeburg, PH & Osten, P 2009, 'Fluorescent Arc/Arg3.1 indicator mice: a versatile tool to study brain activity changes in vitro and in vivo.', J NEUROSCI METH, Jg. 184, Nr. 1, 1, S. 25-36. <http://www.ncbi.nlm.nih.gov/pubmed/19628007?dopt=Citation>

APA

Grinevich, V., Kolleker, A., Eliava, M., Takada, N., Takuma, H., Fukazawa, Y., Shigemoto, R., Kuhl, D., Waters, J., Seeburg, P. H., & Osten, P. (2009). Fluorescent Arc/Arg3.1 indicator mice: a versatile tool to study brain activity changes in vitro and in vivo. J NEUROSCI METH, 184(1), 25-36. [1]. http://www.ncbi.nlm.nih.gov/pubmed/19628007?dopt=Citation

Vancouver

Grinevich V, Kolleker A, Eliava M, Takada N, Takuma H, Fukazawa Y et al. Fluorescent Arc/Arg3.1 indicator mice: a versatile tool to study brain activity changes in vitro and in vivo. J NEUROSCI METH. 2009;184(1):25-36. 1.

Bibtex

@article{d3cc802dfa384cfeb08a1f4b65248532,
title = "Fluorescent Arc/Arg3.1 indicator mice: a versatile tool to study brain activity changes in vitro and in vivo.",
abstract = "The brain-specific immediate early gene Arc/Arg3.1 is induced in response to a variety of stimuli, including sensory and behavior-linked neural activity. Here we report the generation of transgenic mice, termed TgArc/Arg3.1-d4EGFP, expressing a 4-h half-life form of enhanced green fluorescent protein (d4EGFP) under the control of the Arc/Arg3.1 promoter. We show that d4EGFP-mediated fluorescence faithfully reports Arc/Arg3.1 induction in response to physiological, pathological and pharmacological stimuli, and that this fluorescence permits electrical recording from activated neurons in the live mouse. Moreover, the fluorescent Arc/Arg3.1 indicator revealed activity changes in circumscribed brain areas in distinct modes of stress and in a mouse model of Alzheimer's disease. These findings identify the TgArc/Arg3.1-d4EGFP mouse as a versatile tool to monitor Arc/Arg3.1 induction in neural circuits, both in vitro and in vivo.",
author = "Valery Grinevich and Alexander Kolleker and Marina Eliava and Naoki Takada and Hiroshi Takuma and Yugo Fukazawa and Ryuichi Shigemoto and Dietmar Kuhl and Jack Waters and Seeburg, {Peter H} and Pavel Osten",
year = "2009",
language = "Deutsch",
volume = "184",
pages = "25--36",
journal = "J NEUROSCI METH",
issn = "0165-0270",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Fluorescent Arc/Arg3.1 indicator mice: a versatile tool to study brain activity changes in vitro and in vivo.

AU - Grinevich, Valery

AU - Kolleker, Alexander

AU - Eliava, Marina

AU - Takada, Naoki

AU - Takuma, Hiroshi

AU - Fukazawa, Yugo

AU - Shigemoto, Ryuichi

AU - Kuhl, Dietmar

AU - Waters, Jack

AU - Seeburg, Peter H

AU - Osten, Pavel

PY - 2009

Y1 - 2009

N2 - The brain-specific immediate early gene Arc/Arg3.1 is induced in response to a variety of stimuli, including sensory and behavior-linked neural activity. Here we report the generation of transgenic mice, termed TgArc/Arg3.1-d4EGFP, expressing a 4-h half-life form of enhanced green fluorescent protein (d4EGFP) under the control of the Arc/Arg3.1 promoter. We show that d4EGFP-mediated fluorescence faithfully reports Arc/Arg3.1 induction in response to physiological, pathological and pharmacological stimuli, and that this fluorescence permits electrical recording from activated neurons in the live mouse. Moreover, the fluorescent Arc/Arg3.1 indicator revealed activity changes in circumscribed brain areas in distinct modes of stress and in a mouse model of Alzheimer's disease. These findings identify the TgArc/Arg3.1-d4EGFP mouse as a versatile tool to monitor Arc/Arg3.1 induction in neural circuits, both in vitro and in vivo.

AB - The brain-specific immediate early gene Arc/Arg3.1 is induced in response to a variety of stimuli, including sensory and behavior-linked neural activity. Here we report the generation of transgenic mice, termed TgArc/Arg3.1-d4EGFP, expressing a 4-h half-life form of enhanced green fluorescent protein (d4EGFP) under the control of the Arc/Arg3.1 promoter. We show that d4EGFP-mediated fluorescence faithfully reports Arc/Arg3.1 induction in response to physiological, pathological and pharmacological stimuli, and that this fluorescence permits electrical recording from activated neurons in the live mouse. Moreover, the fluorescent Arc/Arg3.1 indicator revealed activity changes in circumscribed brain areas in distinct modes of stress and in a mouse model of Alzheimer's disease. These findings identify the TgArc/Arg3.1-d4EGFP mouse as a versatile tool to monitor Arc/Arg3.1 induction in neural circuits, both in vitro and in vivo.

M3 - SCORING: Zeitschriftenaufsatz

VL - 184

SP - 25

EP - 36

JO - J NEUROSCI METH

JF - J NEUROSCI METH

SN - 0165-0270

IS - 1

M1 - 1

ER -