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Flow cytometric determination of the time of metastasis during fractionated radiation therapy of the rat rhabdomyosarcoma R1H.

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Flow cytometric determination of the time of metastasis during fractionated radiation therapy of the rat rhabdomyosarcoma R1H. / Baumann, M; Becker, S; Krüger, H J; Vogler, H; Maurer, T; Beck-Bornholdt, Hans-Peter.

in: INT J RADIAT BIOL, Jahrgang 58, Nr. 2, 2, 1990, S. 361-369.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Baumann, M, Becker, S, Krüger, HJ, Vogler, H, Maurer, T & Beck-Bornholdt, H-P 1990, 'Flow cytometric determination of the time of metastasis during fractionated radiation therapy of the rat rhabdomyosarcoma R1H.', INT J RADIAT BIOL, Jg. 58, Nr. 2, 2, S. 361-369. <http://www.ncbi.nlm.nih.gov/pubmed/1974582?dopt=Citation>

APA

Baumann, M., Becker, S., Krüger, H. J., Vogler, H., Maurer, T., & Beck-Bornholdt, H-P. (1990). Flow cytometric determination of the time of metastasis during fractionated radiation therapy of the rat rhabdomyosarcoma R1H. INT J RADIAT BIOL, 58(2), 361-369. [2]. http://www.ncbi.nlm.nih.gov/pubmed/1974582?dopt=Citation

Vancouver

Baumann M, Becker S, Krüger HJ, Vogler H, Maurer T, Beck-Bornholdt H-P. Flow cytometric determination of the time of metastasis during fractionated radiation therapy of the rat rhabdomyosarcoma R1H. INT J RADIAT BIOL. 1990;58(2):361-369. 2.

Bibtex

@article{078bb6f777bd4270992d7a8959328e56,
title = "Flow cytometric determination of the time of metastasis during fractionated radiation therapy of the rat rhabdomyosarcoma R1H.",
abstract = "A technique is presented for determining the time of metastasis during fractionated radiation therapy of the rat rhabdomyosarcoma R1H by flow cytmetric DNA index measurements. The DNA index is the relative DNA content of the tumour cells compared with normal cells. The DNA index of the highly hyperploid R1H tumour decreases linearly during radiation therapy dependent on the total dose applied, with a rate of 0.22% per Gy. Since metastatic cells escape further irradiation, their DNA index should correspond to the DNA index at time of spread. If so, cells disseminated late during a course of fractionated irradiation are expected to produce symptoms later and to have a lower DNA index compared with cells that metastasized at the start of treatment. The results obtained fitted these expectations, showing that timing of metastases by DNA flow cytometry, in principle, is possible. A first application of this method indicates that the risk per clonogenic R1H tumour cell to matastasize increases during fractionated irradiation.",
author = "M Baumann and S Becker and Kr{\"u}ger, {H J} and H Vogler and T Maurer and Hans-Peter Beck-Bornholdt",
year = "1990",
language = "Deutsch",
volume = "58",
pages = "361--369",
journal = "INT J RADIAT BIOL",
issn = "0955-3002",
publisher = "Taylor & Francis",
number = "2",

}

RIS

TY - JOUR

T1 - Flow cytometric determination of the time of metastasis during fractionated radiation therapy of the rat rhabdomyosarcoma R1H.

AU - Baumann, M

AU - Becker, S

AU - Krüger, H J

AU - Vogler, H

AU - Maurer, T

AU - Beck-Bornholdt, Hans-Peter

PY - 1990

Y1 - 1990

N2 - A technique is presented for determining the time of metastasis during fractionated radiation therapy of the rat rhabdomyosarcoma R1H by flow cytmetric DNA index measurements. The DNA index is the relative DNA content of the tumour cells compared with normal cells. The DNA index of the highly hyperploid R1H tumour decreases linearly during radiation therapy dependent on the total dose applied, with a rate of 0.22% per Gy. Since metastatic cells escape further irradiation, their DNA index should correspond to the DNA index at time of spread. If so, cells disseminated late during a course of fractionated irradiation are expected to produce symptoms later and to have a lower DNA index compared with cells that metastasized at the start of treatment. The results obtained fitted these expectations, showing that timing of metastases by DNA flow cytometry, in principle, is possible. A first application of this method indicates that the risk per clonogenic R1H tumour cell to matastasize increases during fractionated irradiation.

AB - A technique is presented for determining the time of metastasis during fractionated radiation therapy of the rat rhabdomyosarcoma R1H by flow cytmetric DNA index measurements. The DNA index is the relative DNA content of the tumour cells compared with normal cells. The DNA index of the highly hyperploid R1H tumour decreases linearly during radiation therapy dependent on the total dose applied, with a rate of 0.22% per Gy. Since metastatic cells escape further irradiation, their DNA index should correspond to the DNA index at time of spread. If so, cells disseminated late during a course of fractionated irradiation are expected to produce symptoms later and to have a lower DNA index compared with cells that metastasized at the start of treatment. The results obtained fitted these expectations, showing that timing of metastases by DNA flow cytometry, in principle, is possible. A first application of this method indicates that the risk per clonogenic R1H tumour cell to matastasize increases during fractionated irradiation.

M3 - SCORING: Zeitschriftenaufsatz

VL - 58

SP - 361

EP - 369

JO - INT J RADIAT BIOL

JF - INT J RADIAT BIOL

SN - 0955-3002

IS - 2

M1 - 2

ER -