Flexible cerebral connectivity patterns subserve contextual modulations of pain.
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Flexible cerebral connectivity patterns subserve contextual modulations of pain. / Ploner, Markus; Lee, Michael C; Wiech, Katja; Bingel, Ulrike; Tracey, Irene.
in: CEREB CORTEX, Jahrgang 21, Nr. 3, 3, 2011, S. 719-726.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Flexible cerebral connectivity patterns subserve contextual modulations of pain.
AU - Ploner, Markus
AU - Lee, Michael C
AU - Wiech, Katja
AU - Bingel, Ulrike
AU - Tracey, Irene
PY - 2011
Y1 - 2011
N2 - The perception of pain can be significantly modulated by the behavioral context. Here, we investigated how contextual modulations of pain are subserved in the human brain. We independently modulated the attentional and emotional context of painful stimuli and recorded brain activity by using functional magnetic resonance imaging. Our results confirm that attention to pain and a negative emotional context increases pain perception and this is concomitantly associated with increased neural activity in the anterior insular cortex. Connectivity analyses further reveal that during attentional and emotional modulations of pain, the anterior insula selectively and flexibly connects to attentional and emotional brain networks in frontoparietal and medial temporal lobe areas, respectively. We conclude that the flexible functional connectivity of the anterior insula to other functional systems of the brain, for example, attentional and emotional brain networks, subserves the extraordinary sensitivity of the pain experience to contextual modulations.
AB - The perception of pain can be significantly modulated by the behavioral context. Here, we investigated how contextual modulations of pain are subserved in the human brain. We independently modulated the attentional and emotional context of painful stimuli and recorded brain activity by using functional magnetic resonance imaging. Our results confirm that attention to pain and a negative emotional context increases pain perception and this is concomitantly associated with increased neural activity in the anterior insular cortex. Connectivity analyses further reveal that during attentional and emotional modulations of pain, the anterior insula selectively and flexibly connects to attentional and emotional brain networks in frontoparietal and medial temporal lobe areas, respectively. We conclude that the flexible functional connectivity of the anterior insula to other functional systems of the brain, for example, attentional and emotional brain networks, subserves the extraordinary sensitivity of the pain experience to contextual modulations.
KW - Adult
KW - Humans
KW - Male
KW - Young Adult
KW - Magnetic Resonance Imaging
KW - Image Processing, Computer-Assisted
KW - Brain Mapping
KW - Emotions/physiology
KW - Cerebral Cortex/physiology
KW - Neural Pathways/physiology
KW - Attention/physiology
KW - Pain/psychology
KW - Pain Perception/physiology
KW - Adult
KW - Humans
KW - Male
KW - Young Adult
KW - Magnetic Resonance Imaging
KW - Image Processing, Computer-Assisted
KW - Brain Mapping
KW - Emotions/physiology
KW - Cerebral Cortex/physiology
KW - Neural Pathways/physiology
KW - Attention/physiology
KW - Pain/psychology
KW - Pain Perception/physiology
M3 - SCORING: Journal article
VL - 21
SP - 719
EP - 726
JO - CEREB CORTEX
JF - CEREB CORTEX
SN - 1047-3211
IS - 3
M1 - 3
ER -
