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Five polymorphisms and breast cancer risk: results from the Breast Cancer Association Consortium.

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Five polymorphisms and breast cancer risk: results from the Breast Cancer Association Consortium. / Gaudet, Mia M; Milne, Roger L; Cox, Angela; Camp, Nicola J; Goode Ellen, L; Humphreys, Manjeet K; Dunning, Alison M; Morrison, Jonathan; Giles, Graham G; Severi, Gianluca; Baglietto, Laura; English, Dallas R; Couch, Fergus J; Olson, Janet E; Wang, Xianshu; Jenny, Chang-Claude; Flesch-Janys, Dieter; Abbas, Sascha; Salazar, Ramona; Mannermaa, Arto; Kataja, Vesa; Kosma, Veli-Matti; Lindblom, Annika; Margolin, Sara; Heikkinen, Tuomas; Kämpjärvi, Kati; Aaltonen, Kirsimari; Nevanlinna, Heli; Bogdanova, Natalia; Coinac, Irina; Schürmann, Peter; Dörk, Thilo; Bartram, Claus R; Schmutzler, Rita K; Tchatchou, Sandrine; Burwinkel, Barbara; Brauch, Hiltrud; Torres, Diana; Hamann, Ute; Justenhoven, Christina; Ribas, Gloria; Arias, José I; Benitez, Javier; Bojesen, Stig E; Nordestgaard, Børge G; Flyger, Henrik L; Peto, Julian; Fletcher, Olivia; Johnson, Nichola; Isabel, Dos Santos Silva; Fasching, Peter A; Beckmann, Matthias W; Strick, Reiner; Ekici, Arif B; Broeks, Annegien; Schmidt, Marjanka K; Leeuwen, van; Flora, E; Veer, Van't; Laura, J; Southey, Melissa C; Hopper, John L; Apicella, Carmel; Haiman, Christopher A; Henderson, Brian E; Loic, Le Marchand; Kolonel, Laurence N; Kristensen, Vessela; Grethe, Grenaker Alnaes; Hunter, David J; Kraft, Peter; Cox, David G; Hankinson, Susan E; Seynaeve, Caroline; Vreeswijk, Maaike P G; Tollenaar, Rob A E M; Devilee, Peter; Chanock, Stephen; Lissowska, Jolanta; Brinton, Louise; Peplonska, Beata; Czene, Kamila; Hall, Per; Li, Yuqing; Liu, Jianjun; Balasubramanian, Sabapathy; Rafii, Saeed; Reed, Malcolm W R; Pooley, Karen A; Conroy, Don; Baynes, Caroline; Kang, Daehee; Yoo, Keun-Young; Noh, Dong-Young; Ahn, Sei-Hyun; Shen, Chen-Yang; Wang, Hui-Chun; Yu, Jyh-Cherng; Wu, Pei-Ei; Anton-Culver, Hoda; Ziogoas, Argyrios; Egan, Kathleen; Newcomb, Polly; Titus-Ernstoff, Linda; Amy, Trentham Dietz; Sigurdson, Alice J; Alexander, Bruce H; Bhatti, Parveen; Allen-Brady, Kristina; Cannon-Albright, Lisa A; Wong, Jathine; Chenevix-Trench, Georgia; Spurdle, Amanda B; Beesley, Jonathan; Pharoah, Paul D P; Easton, Doug F; Garcia-Closas, Montserrat.

in: CANCER EPIDEM BIOMAR, Jahrgang 18, Nr. 5, 5, 2009, S. 1610-1616.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Gaudet, MM, Milne, RL, Cox, A, Camp, NJ, Goode Ellen, L, Humphreys, MK, Dunning, AM, Morrison, J, Giles, GG, Severi, G, Baglietto, L, English, DR, Couch, FJ, Olson, JE, Wang, X, Jenny, C-C, Flesch-Janys, D, Abbas, S, Salazar, R, Mannermaa, A, Kataja, V, Kosma, V-M, Lindblom, A, Margolin, S, Heikkinen, T, Kämpjärvi, K, Aaltonen, K, Nevanlinna, H, Bogdanova, N, Coinac, I, Schürmann, P, Dörk, T, Bartram, CR, Schmutzler, RK, Tchatchou, S, Burwinkel, B, Brauch, H, Torres, D, Hamann, U, Justenhoven, C, Ribas, G, Arias, JI, Benitez, J, Bojesen, SE, Nordestgaard, BG, Flyger, HL, Peto, J, Fletcher, O, Johnson, N, Isabel, DSS, Fasching, PA, Beckmann, MW, Strick, R, Ekici, AB, Broeks, A, Schmidt, MK, Leeuwen, V, Flora, E, Veer, V, Laura, J, Southey, MC, Hopper, JL, Apicella, C, Haiman, CA, Henderson, BE, Loic, LM, Kolonel, LN, Kristensen, V, Grethe, GA, Hunter, DJ, Kraft, P, Cox, DG, Hankinson, SE, Seynaeve, C, Vreeswijk, MPG, Tollenaar, RAEM, Devilee, P, Chanock, S, Lissowska, J, Brinton, L, Peplonska, B, Czene, K, Hall, P, Li, Y, Liu, J, Balasubramanian, S, Rafii, S, Reed, MWR, Pooley, KA, Conroy, D, Baynes, C, Kang, D, Yoo, K-Y, Noh, D-Y, Ahn, S-H, Shen, C-Y, Wang, H-C, Yu, J-C, Wu, P-E, Anton-Culver, H, Ziogoas, A, Egan, K, Newcomb, P, Titus-Ernstoff, L, Amy, TD, Sigurdson, AJ, Alexander, BH, Bhatti, P, Allen-Brady, K, Cannon-Albright, LA, Wong, J, Chenevix-Trench, G, Spurdle, AB, Beesley, J, Pharoah, PDP, Easton, DF & Garcia-Closas, M 2009, 'Five polymorphisms and breast cancer risk: results from the Breast Cancer Association Consortium.', CANCER EPIDEM BIOMAR, Jg. 18, Nr. 5, 5, S. 1610-1616. <http://www.ncbi.nlm.nih.gov/pubmed/19423537?dopt=Citation>

APA

Gaudet, M. M., Milne, R. L., Cox, A., Camp, N. J., Goode Ellen, L., Humphreys, M. K., Dunning, A. M., Morrison, J., Giles, G. G., Severi, G., Baglietto, L., English, D. R., Couch, F. J., Olson, J. E., Wang, X., Jenny, C-C., Flesch-Janys, D., Abbas, S., Salazar, R., ... Garcia-Closas, M. (2009). Five polymorphisms and breast cancer risk: results from the Breast Cancer Association Consortium. CANCER EPIDEM BIOMAR, 18(5), 1610-1616. [5]. http://www.ncbi.nlm.nih.gov/pubmed/19423537?dopt=Citation

Vancouver

Gaudet MM, Milne RL, Cox A, Camp NJ, Goode Ellen L, Humphreys MK et al. Five polymorphisms and breast cancer risk: results from the Breast Cancer Association Consortium. CANCER EPIDEM BIOMAR. 2009;18(5):1610-1616. 5.

Bibtex

@article{6cbe2d0182a2460b8756834586cb827c,
title = "Five polymorphisms and breast cancer risk: results from the Breast Cancer Association Consortium.",
abstract = "Previous studies have suggested that minor alleles for ERCC4 rs744154, TNF rs361525, CASP10 rs13010627, PGR rs1042838, and BID rs8190315 may influence breast cancer risk, but the evidence is inconclusive due to their small sample size. These polymorphisms were genotyped in more than 30,000 breast cancer cases and 30,000 controls, primarily of European descent, from 30 studies in the Breast Cancer Association Consortium. We calculated odds ratios (OR) and 95% confidence intervals (95% CI) as a measure of association. We found that the minor alleles for these polymorphisms were not related to invasive breast cancer risk overall in women of European descent: ECCR4 per-allele OR (95% CI) = 0.99 (0.97-1.02), minor allele frequency = 27.5%; TNF 1.00 (0.95-1.06), 5.0%; CASP10 1.02 (0.98-1.07), 6.5%; PGR 1.02 (0.99-1.06), 15.3%; and BID 0.98 (0.86-1.12), 1.7%. However, we observed significant between-study heterogeneity for associations with risk for single-nucleotide polymorphisms (SNP) in CASP10, PGR, and BID. Estimates were imprecise for women of Asian and African descent due to small numbers and lower minor allele frequencies (with the exception of BID SNP). The ORs for each copy of the minor allele were not significantly different by estrogen or progesterone receptor status, nor were any significant interactions found between the polymorphisms and age or family history of breast cancer. In conclusion, our data provide persuasive evidence against an overall association between invasive breast cancer risk and ERCC4 rs744154, TNF rs361525, CASP10 rs13010627, PGR rs1042838, and BID rs8190315 genotypes among women of European descent.",
author = "Gaudet, {Mia M} and Milne, {Roger L} and Angela Cox and Camp, {Nicola J} and {Goode Ellen}, L and Humphreys, {Manjeet K} and Dunning, {Alison M} and Jonathan Morrison and Giles, {Graham G} and Gianluca Severi and Laura Baglietto and English, {Dallas R} and Couch, {Fergus J} and Olson, {Janet E} and Xianshu Wang and Chang-Claude Jenny and Dieter Flesch-Janys and Sascha Abbas and Ramona Salazar and Arto Mannermaa and Vesa Kataja and Veli-Matti Kosma and Annika Lindblom and Sara Margolin and Tuomas Heikkinen and Kati K{\"a}mpj{\"a}rvi and Kirsimari Aaltonen and Heli Nevanlinna and Natalia Bogdanova and Irina Coinac and Peter Sch{\"u}rmann and Thilo D{\"o}rk and Bartram, {Claus R} and Schmutzler, {Rita K} and Sandrine Tchatchou and Barbara Burwinkel and Hiltrud Brauch and Diana Torres and Ute Hamann and Christina Justenhoven and Gloria Ribas and Arias, {Jos{\'e} I} and Javier Benitez and Bojesen, {Stig E} and Nordestgaard, {B{\o}rge G} and Flyger, {Henrik L} and Julian Peto and Olivia Fletcher and Nichola Johnson and Isabel, {Dos Santos Silva} and Fasching, {Peter A} and Beckmann, {Matthias W} and Reiner Strick and Ekici, {Arif B} and Annegien Broeks and Schmidt, {Marjanka K} and van Leeuwen and E Flora and Van't Veer and J Laura and Southey, {Melissa C} and Hopper, {John L} and Carmel Apicella and Haiman, {Christopher A} and Henderson, {Brian E} and Loic, {Le Marchand} and Kolonel, {Laurence N} and Vessela Kristensen and Grethe, {Grenaker Alnaes} and Hunter, {David J} and Peter Kraft and Cox, {David G} and Hankinson, {Susan E} and Caroline Seynaeve and Vreeswijk, {Maaike P G} and Tollenaar, {Rob A E M} and Peter Devilee and Stephen Chanock and Jolanta Lissowska and Louise Brinton and Beata Peplonska and Kamila Czene and Per Hall and Yuqing Li and Jianjun Liu and Sabapathy Balasubramanian and Saeed Rafii and Reed, {Malcolm W R} and Pooley, {Karen A} and Don Conroy and Caroline Baynes and Daehee Kang and Keun-Young Yoo and Dong-Young Noh and Sei-Hyun Ahn and Chen-Yang Shen and Hui-Chun Wang and Jyh-Cherng Yu and Pei-Ei Wu and Hoda Anton-Culver and Argyrios Ziogoas and Kathleen Egan and Polly Newcomb and Linda Titus-Ernstoff and Amy, {Trentham Dietz} and Sigurdson, {Alice J} and Alexander, {Bruce H} and Parveen Bhatti and Kristina Allen-Brady and Cannon-Albright, {Lisa A} and Jathine Wong and Georgia Chenevix-Trench and Spurdle, {Amanda B} and Jonathan Beesley and Pharoah, {Paul D P} and Easton, {Doug F} and Montserrat Garcia-Closas",
year = "2009",
language = "Deutsch",
volume = "18",
pages = "1610--1616",
journal = "CANCER EPIDEM BIOMAR",
issn = "1055-9965",
publisher = "American Association for Cancer Research Inc.",
number = "5",

}

RIS

TY - JOUR

T1 - Five polymorphisms and breast cancer risk: results from the Breast Cancer Association Consortium.

AU - Gaudet, Mia M

AU - Milne, Roger L

AU - Cox, Angela

AU - Camp, Nicola J

AU - Goode Ellen, L

AU - Humphreys, Manjeet K

AU - Dunning, Alison M

AU - Morrison, Jonathan

AU - Giles, Graham G

AU - Severi, Gianluca

AU - Baglietto, Laura

AU - English, Dallas R

AU - Couch, Fergus J

AU - Olson, Janet E

AU - Wang, Xianshu

AU - Jenny, Chang-Claude

AU - Flesch-Janys, Dieter

AU - Abbas, Sascha

AU - Salazar, Ramona

AU - Mannermaa, Arto

AU - Kataja, Vesa

AU - Kosma, Veli-Matti

AU - Lindblom, Annika

AU - Margolin, Sara

AU - Heikkinen, Tuomas

AU - Kämpjärvi, Kati

AU - Aaltonen, Kirsimari

AU - Nevanlinna, Heli

AU - Bogdanova, Natalia

AU - Coinac, Irina

AU - Schürmann, Peter

AU - Dörk, Thilo

AU - Bartram, Claus R

AU - Schmutzler, Rita K

AU - Tchatchou, Sandrine

AU - Burwinkel, Barbara

AU - Brauch, Hiltrud

AU - Torres, Diana

AU - Hamann, Ute

AU - Justenhoven, Christina

AU - Ribas, Gloria

AU - Arias, José I

AU - Benitez, Javier

AU - Bojesen, Stig E

AU - Nordestgaard, Børge G

AU - Flyger, Henrik L

AU - Peto, Julian

AU - Fletcher, Olivia

AU - Johnson, Nichola

AU - Isabel, Dos Santos Silva

AU - Fasching, Peter A

AU - Beckmann, Matthias W

AU - Strick, Reiner

AU - Ekici, Arif B

AU - Broeks, Annegien

AU - Schmidt, Marjanka K

AU - Leeuwen, van

AU - Flora, E

AU - Veer, Van't

AU - Laura, J

AU - Southey, Melissa C

AU - Hopper, John L

AU - Apicella, Carmel

AU - Haiman, Christopher A

AU - Henderson, Brian E

AU - Loic, Le Marchand

AU - Kolonel, Laurence N

AU - Kristensen, Vessela

AU - Grethe, Grenaker Alnaes

AU - Hunter, David J

AU - Kraft, Peter

AU - Cox, David G

AU - Hankinson, Susan E

AU - Seynaeve, Caroline

AU - Vreeswijk, Maaike P G

AU - Tollenaar, Rob A E M

AU - Devilee, Peter

AU - Chanock, Stephen

AU - Lissowska, Jolanta

AU - Brinton, Louise

AU - Peplonska, Beata

AU - Czene, Kamila

AU - Hall, Per

AU - Li, Yuqing

AU - Liu, Jianjun

AU - Balasubramanian, Sabapathy

AU - Rafii, Saeed

AU - Reed, Malcolm W R

AU - Pooley, Karen A

AU - Conroy, Don

AU - Baynes, Caroline

AU - Kang, Daehee

AU - Yoo, Keun-Young

AU - Noh, Dong-Young

AU - Ahn, Sei-Hyun

AU - Shen, Chen-Yang

AU - Wang, Hui-Chun

AU - Yu, Jyh-Cherng

AU - Wu, Pei-Ei

AU - Anton-Culver, Hoda

AU - Ziogoas, Argyrios

AU - Egan, Kathleen

AU - Newcomb, Polly

AU - Titus-Ernstoff, Linda

AU - Amy, Trentham Dietz

AU - Sigurdson, Alice J

AU - Alexander, Bruce H

AU - Bhatti, Parveen

AU - Allen-Brady, Kristina

AU - Cannon-Albright, Lisa A

AU - Wong, Jathine

AU - Chenevix-Trench, Georgia

AU - Spurdle, Amanda B

AU - Beesley, Jonathan

AU - Pharoah, Paul D P

AU - Easton, Doug F

AU - Garcia-Closas, Montserrat

PY - 2009

Y1 - 2009

N2 - Previous studies have suggested that minor alleles for ERCC4 rs744154, TNF rs361525, CASP10 rs13010627, PGR rs1042838, and BID rs8190315 may influence breast cancer risk, but the evidence is inconclusive due to their small sample size. These polymorphisms were genotyped in more than 30,000 breast cancer cases and 30,000 controls, primarily of European descent, from 30 studies in the Breast Cancer Association Consortium. We calculated odds ratios (OR) and 95% confidence intervals (95% CI) as a measure of association. We found that the minor alleles for these polymorphisms were not related to invasive breast cancer risk overall in women of European descent: ECCR4 per-allele OR (95% CI) = 0.99 (0.97-1.02), minor allele frequency = 27.5%; TNF 1.00 (0.95-1.06), 5.0%; CASP10 1.02 (0.98-1.07), 6.5%; PGR 1.02 (0.99-1.06), 15.3%; and BID 0.98 (0.86-1.12), 1.7%. However, we observed significant between-study heterogeneity for associations with risk for single-nucleotide polymorphisms (SNP) in CASP10, PGR, and BID. Estimates were imprecise for women of Asian and African descent due to small numbers and lower minor allele frequencies (with the exception of BID SNP). The ORs for each copy of the minor allele were not significantly different by estrogen or progesterone receptor status, nor were any significant interactions found between the polymorphisms and age or family history of breast cancer. In conclusion, our data provide persuasive evidence against an overall association between invasive breast cancer risk and ERCC4 rs744154, TNF rs361525, CASP10 rs13010627, PGR rs1042838, and BID rs8190315 genotypes among women of European descent.

AB - Previous studies have suggested that minor alleles for ERCC4 rs744154, TNF rs361525, CASP10 rs13010627, PGR rs1042838, and BID rs8190315 may influence breast cancer risk, but the evidence is inconclusive due to their small sample size. These polymorphisms were genotyped in more than 30,000 breast cancer cases and 30,000 controls, primarily of European descent, from 30 studies in the Breast Cancer Association Consortium. We calculated odds ratios (OR) and 95% confidence intervals (95% CI) as a measure of association. We found that the minor alleles for these polymorphisms were not related to invasive breast cancer risk overall in women of European descent: ECCR4 per-allele OR (95% CI) = 0.99 (0.97-1.02), minor allele frequency = 27.5%; TNF 1.00 (0.95-1.06), 5.0%; CASP10 1.02 (0.98-1.07), 6.5%; PGR 1.02 (0.99-1.06), 15.3%; and BID 0.98 (0.86-1.12), 1.7%. However, we observed significant between-study heterogeneity for associations with risk for single-nucleotide polymorphisms (SNP) in CASP10, PGR, and BID. Estimates were imprecise for women of Asian and African descent due to small numbers and lower minor allele frequencies (with the exception of BID SNP). The ORs for each copy of the minor allele were not significantly different by estrogen or progesterone receptor status, nor were any significant interactions found between the polymorphisms and age or family history of breast cancer. In conclusion, our data provide persuasive evidence against an overall association between invasive breast cancer risk and ERCC4 rs744154, TNF rs361525, CASP10 rs13010627, PGR rs1042838, and BID rs8190315 genotypes among women of European descent.

M3 - SCORING: Zeitschriftenaufsatz

VL - 18

SP - 1610

EP - 1616

JO - CANCER EPIDEM BIOMAR

JF - CANCER EPIDEM BIOMAR

SN - 1055-9965

IS - 5

M1 - 5

ER -