PortalPublikationenFirst results of the "Lean European Open Survey on SARS-CoV-...

First results of the "Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS)"

Standard

First results of the "Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS)". / Jakob, Carolin E M; Borgmann, Stefan; Duygu, Fazilet; Behrends, Uta; Hower, Martin; Merle, Uta; Friedrichs, Anette; Tometten, Lukas; Hanses, Frank; Jung, Norma; Rieg, Siegbert; Wille, Kai; Grüner, Beate; Klinker, Hartwig; Gersbacher-Runge, Nicole; Hellwig, Kerstin; Eberwein, Lukas; Dolff, Sebastian; Rauschning, Dominic; von Bergwelt-Baildon, Michael; Lanznaster, Julia; Strauß, Richard; Trauth, Janina; de With, Katja; Ruethrich, Maria; Lueck, Catherina; Nattermann, Jacob; Tscharntke, Lene; Pilgram, Lisa; Fuhrmann, Sandra; Classen, Annika; Stecher, Melanie; Schons, Maximilian; Spinner, Christoph; Vehreschild, Jörg Janne.

in: INFECTION, Jahrgang 49, Nr. 1, 02.2021, S. 63-73.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Jakob, CEM, Borgmann, S, Duygu, F, Behrends, U, Hower, M, Merle, U, Friedrichs, A, Tometten, L, Hanses, F, Jung, N, Rieg, S, Wille, K, Grüner, B, Klinker, H, Gersbacher-Runge, N, Hellwig, K, Eberwein, L, Dolff, S, Rauschning, D, von Bergwelt-Baildon, M, Lanznaster, J, Strauß, R, Trauth, J, de With, K, Ruethrich, M, Lueck, C, Nattermann, J, Tscharntke, L, Pilgram, L, Fuhrmann, S, Classen, A, Stecher, M, Schons, M, Spinner, C & Vehreschild, JJ 2021, 'First results of the "Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS)"', INFECTION, Jg. 49, Nr. 1, S. 63-73. https://doi.org/10.1007/s15010-020-01499-0

APA

Jakob, C. E. M., Borgmann, S., Duygu, F., Behrends, U., Hower, M., Merle, U., Friedrichs, A., Tometten, L., Hanses, F., Jung, N., Rieg, S., Wille, K., Grüner, B., Klinker, H., Gersbacher-Runge, N., Hellwig, K., Eberwein, L., Dolff, S., Rauschning, D., ... Vehreschild, J. J. (2021). First results of the "Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS)". INFECTION, 49(1), 63-73. https://doi.org/10.1007/s15010-020-01499-0

Vancouver

Jakob CEM, Borgmann S, Duygu F, Behrends U, Hower M, Merle U et al. First results of the "Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS)". INFECTION. 2021 Feb;49(1):63-73. https://doi.org/10.1007/s15010-020-01499-0

Bibtex

@article{3fc56cb0d9f943608de846e745dbbeaa,
title = "First results of the {"}Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS){"}",
abstract = "PURPOSE: Knowledge regarding patients' clinical condition at severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection is sparse. Data in the international, multicenter Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS) cohort study may enhance the understanding of COVID-19.METHODS: Sociodemographic and clinical characteristics of SARS-CoV-2-infected patients, enrolled in the LEOSS cohort study between March 16, 2020, and May 14, 2020, were analyzed. Associations between baseline characteristics and clinical stages at diagnosis (uncomplicated vs. complicated) were assessed using logistic regression models.RESULTS: We included 2155 patients, 59.7% (1,287/2,155) were male; the most common age category was 66-85 years (39.6%; 500/2,155). The primary COVID-19 diagnosis was made in 35.0% (755/2,155) during complicated clinical stages. A significant univariate association between age; sex; body mass index; smoking; diabetes; cardiovascular, pulmonary, neurological, and kidney diseases; ACE inhibitor therapy; statin intake and an increased risk for complicated clinical stages of COVID-19 at diagnosis was found. Multivariable analysis revealed that advanced age [46-65 years: adjusted odds ratio (aOR): 1.73, 95% CI 1.25-2.42, p = 0.001; 66-85 years: aOR 1.93, 95% CI 1.36-2.74, p < 0.001; > 85 years: aOR 2.38, 95% CI 1.49-3.81, p < 0.001 vs. individuals aged 26-45 years], male sex (aOR 1.23, 95% CI 1.01-1.50, p = 0.040), cardiovascular disease (aOR 1.37, 95% CI 1.09-1.72, p = 0.007), and diabetes (aOR 1.33, 95% CI 1.04-1.69, p = 0.023) were associated with complicated stages of COVID-19 at diagnosis.CONCLUSION: The LEOSS cohort identified age, cardiovascular disease, diabetes and male sex as risk factors for complicated disease stages at SARS-CoV-2 diagnosis, thus confirming previous data. Further data regarding outcomes of the natural course of COVID-19 and the influence of treatment are required.",
keywords = "Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Angiotensin-Converting Enzyme Inhibitors/adverse effects, Body Mass Index, COVID-19/diagnosis, Cardiovascular Diseases/diagnosis, Cohort Studies, Comorbidity, Diabetes Mellitus/diagnosis, Europe/epidemiology, Female, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects, Kidney Diseases/diagnosis, Logistic Models, Lung Diseases/diagnosis, Male, Middle Aged, Pandemics, SARS-CoV-2/pathogenicity, Severity of Illness Index, Sex Factors",
author = "Jakob, {Carolin E M} and Stefan Borgmann and Fazilet Duygu and Uta Behrends and Martin Hower and Uta Merle and Anette Friedrichs and Lukas Tometten and Frank Hanses and Norma Jung and Siegbert Rieg and Kai Wille and Beate Gr{\"u}ner and Hartwig Klinker and Nicole Gersbacher-Runge and Kerstin Hellwig and Lukas Eberwein and Sebastian Dolff and Dominic Rauschning and {von Bergwelt-Baildon}, Michael and Julia Lanznaster and Richard Strau{\ss} and Janina Trauth and {de With}, Katja and Maria Ruethrich and Catherina Lueck and Jacob Nattermann and Lene Tscharntke and Lisa Pilgram and Sandra Fuhrmann and Annika Classen and Melanie Stecher and Maximilian Schons and Christoph Spinner and Vehreschild, {J{\"o}rg Janne}",
year = "2021",
month = feb,
doi = "10.1007/s15010-020-01499-0",
language = "English",
volume = "49",
pages = "63--73",
journal = "INFECTION",
issn = "0300-8126",
publisher = "Urban und Vogel",
number = "1",

}

RIS

TY - JOUR

T1 - First results of the "Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS)"

AU - Jakob, Carolin E M

AU - Borgmann, Stefan

AU - Duygu, Fazilet

AU - Behrends, Uta

AU - Hower, Martin

AU - Merle, Uta

AU - Friedrichs, Anette

AU - Tometten, Lukas

AU - Hanses, Frank

AU - Jung, Norma

AU - Rieg, Siegbert

AU - Wille, Kai

AU - Grüner, Beate

AU - Klinker, Hartwig

AU - Gersbacher-Runge, Nicole

AU - Hellwig, Kerstin

AU - Eberwein, Lukas

AU - Dolff, Sebastian

AU - Rauschning, Dominic

AU - von Bergwelt-Baildon, Michael

AU - Lanznaster, Julia

AU - Strauß, Richard

AU - Trauth, Janina

AU - de With, Katja

AU - Ruethrich, Maria

AU - Lueck, Catherina

AU - Nattermann, Jacob

AU - Tscharntke, Lene

AU - Pilgram, Lisa

AU - Fuhrmann, Sandra

AU - Classen, Annika

AU - Stecher, Melanie

AU - Schons, Maximilian

AU - Spinner, Christoph

AU - Vehreschild, Jörg Janne

PY - 2021/2

Y1 - 2021/2

N2 - PURPOSE: Knowledge regarding patients' clinical condition at severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection is sparse. Data in the international, multicenter Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS) cohort study may enhance the understanding of COVID-19.METHODS: Sociodemographic and clinical characteristics of SARS-CoV-2-infected patients, enrolled in the LEOSS cohort study between March 16, 2020, and May 14, 2020, were analyzed. Associations between baseline characteristics and clinical stages at diagnosis (uncomplicated vs. complicated) were assessed using logistic regression models.RESULTS: We included 2155 patients, 59.7% (1,287/2,155) were male; the most common age category was 66-85 years (39.6%; 500/2,155). The primary COVID-19 diagnosis was made in 35.0% (755/2,155) during complicated clinical stages. A significant univariate association between age; sex; body mass index; smoking; diabetes; cardiovascular, pulmonary, neurological, and kidney diseases; ACE inhibitor therapy; statin intake and an increased risk for complicated clinical stages of COVID-19 at diagnosis was found. Multivariable analysis revealed that advanced age [46-65 years: adjusted odds ratio (aOR): 1.73, 95% CI 1.25-2.42, p = 0.001; 66-85 years: aOR 1.93, 95% CI 1.36-2.74, p < 0.001; > 85 years: aOR 2.38, 95% CI 1.49-3.81, p < 0.001 vs. individuals aged 26-45 years], male sex (aOR 1.23, 95% CI 1.01-1.50, p = 0.040), cardiovascular disease (aOR 1.37, 95% CI 1.09-1.72, p = 0.007), and diabetes (aOR 1.33, 95% CI 1.04-1.69, p = 0.023) were associated with complicated stages of COVID-19 at diagnosis.CONCLUSION: The LEOSS cohort identified age, cardiovascular disease, diabetes and male sex as risk factors for complicated disease stages at SARS-CoV-2 diagnosis, thus confirming previous data. Further data regarding outcomes of the natural course of COVID-19 and the influence of treatment are required.

AB - PURPOSE: Knowledge regarding patients' clinical condition at severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection is sparse. Data in the international, multicenter Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS) cohort study may enhance the understanding of COVID-19.METHODS: Sociodemographic and clinical characteristics of SARS-CoV-2-infected patients, enrolled in the LEOSS cohort study between March 16, 2020, and May 14, 2020, were analyzed. Associations between baseline characteristics and clinical stages at diagnosis (uncomplicated vs. complicated) were assessed using logistic regression models.RESULTS: We included 2155 patients, 59.7% (1,287/2,155) were male; the most common age category was 66-85 years (39.6%; 500/2,155). The primary COVID-19 diagnosis was made in 35.0% (755/2,155) during complicated clinical stages. A significant univariate association between age; sex; body mass index; smoking; diabetes; cardiovascular, pulmonary, neurological, and kidney diseases; ACE inhibitor therapy; statin intake and an increased risk for complicated clinical stages of COVID-19 at diagnosis was found. Multivariable analysis revealed that advanced age [46-65 years: adjusted odds ratio (aOR): 1.73, 95% CI 1.25-2.42, p = 0.001; 66-85 years: aOR 1.93, 95% CI 1.36-2.74, p < 0.001; > 85 years: aOR 2.38, 95% CI 1.49-3.81, p < 0.001 vs. individuals aged 26-45 years], male sex (aOR 1.23, 95% CI 1.01-1.50, p = 0.040), cardiovascular disease (aOR 1.37, 95% CI 1.09-1.72, p = 0.007), and diabetes (aOR 1.33, 95% CI 1.04-1.69, p = 0.023) were associated with complicated stages of COVID-19 at diagnosis.CONCLUSION: The LEOSS cohort identified age, cardiovascular disease, diabetes and male sex as risk factors for complicated disease stages at SARS-CoV-2 diagnosis, thus confirming previous data. Further data regarding outcomes of the natural course of COVID-19 and the influence of treatment are required.

KW - Adolescent

KW - Adult

KW - Age Factors

KW - Aged

KW - Aged, 80 and over

KW - Angiotensin-Converting Enzyme Inhibitors/adverse effects

KW - Body Mass Index

KW - COVID-19/diagnosis

KW - Cardiovascular Diseases/diagnosis

KW - Cohort Studies

KW - Comorbidity

KW - Diabetes Mellitus/diagnosis

KW - Europe/epidemiology

KW - Female

KW - Humans

KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects

KW - Kidney Diseases/diagnosis

KW - Logistic Models

KW - Lung Diseases/diagnosis

KW - Male

KW - Middle Aged

KW - Pandemics

KW - SARS-CoV-2/pathogenicity

KW - Severity of Illness Index

KW - Sex Factors

U2 - 10.1007/s15010-020-01499-0

DO - 10.1007/s15010-020-01499-0

M3 - SCORING: Journal article

C2 - 33001409

VL - 49

SP - 63

EP - 73

JO - INFECTION

JF - INFECTION

SN - 0300-8126

IS - 1

ER -