Fingolimod - ein neuer Immunmodulator
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Fingolimod - ein neuer Immunmodulator. / Friedrich, F W; Eschenhagen, T.
in: DEUT MED WOCHENSCHR, Jahrgang 134, Nr. 42, 01.10.2009, S. 2127-31.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Fingolimod - ein neuer Immunmodulator
AU - Friedrich, F W
AU - Eschenhagen, T
N1 - Copyright Georg Thieme Verlag KG Stuttgart . New York.
PY - 2009/10/1
Y1 - 2009/10/1
N2 - Fingolimod is a derivative of the naturally occurring immunosuppressive substance myriocin, with structural similarity to sphingosine, a ubiquitous sphingolipid. It acts as an immunomodulator interfering with the egress of T and B lymphocytes from secondary lymph organs, which results in lymphopenia. A phase II study in patients with multiple scerosis showed a significant reduction in annual relapse rate and lesions in magnetic resonance imaging with an acceptable rate of side effects. An advantage of fingolimod compared to interferon beta, glatirameracetate and natalizumab is its oral availability. Definitive assessment of the compound has to await the results of trials currently being performed.
AB - Fingolimod is a derivative of the naturally occurring immunosuppressive substance myriocin, with structural similarity to sphingosine, a ubiquitous sphingolipid. It acts as an immunomodulator interfering with the egress of T and B lymphocytes from secondary lymph organs, which results in lymphopenia. A phase II study in patients with multiple scerosis showed a significant reduction in annual relapse rate and lesions in magnetic resonance imaging with an acceptable rate of side effects. An advantage of fingolimod compared to interferon beta, glatirameracetate and natalizumab is its oral availability. Definitive assessment of the compound has to await the results of trials currently being performed.
KW - Biological Availability
KW - Graft Rejection
KW - Humans
KW - Immunosuppressive Agents
KW - Kidney Transplantation
KW - Multiple Sclerosis
KW - Propylene Glycols
KW - Sphingosine
U2 - 10.1055/s-0029-1241903
DO - 10.1055/s-0029-1241903
M3 - SCORING: Zeitschriftenaufsatz
C2 - 19809964
VL - 134
SP - 2127
EP - 2131
JO - DEUT MED WOCHENSCHR
JF - DEUT MED WOCHENSCHR
SN - 0012-0472
IS - 42
ER -