Fighting Staphylococcus epidermidis Biofilm-Associated Infections: Can Iron Be the Key to Success?
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Fighting Staphylococcus epidermidis Biofilm-Associated Infections: Can Iron Be the Key to Success? / Oliveira, Fernando; Rohde, Holger; Vilanova, Manuel; Cerca, Nuno.
in: FRONT CELL INFECT MI, Jahrgang 11, 798563, 2021.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Fighting Staphylococcus epidermidis Biofilm-Associated Infections: Can Iron Be the Key to Success?
AU - Oliveira, Fernando
AU - Rohde, Holger
AU - Vilanova, Manuel
AU - Cerca, Nuno
N1 - Copyright © 2021 Oliveira, Rohde, Vilanova and Cerca.
PY - 2021
Y1 - 2021
N2 - Staphylococcus epidermidis is one of the most important commensal microorganisms of human skin and mucosae. However, this bacterial species is also the cause of severe infections in immunocompromised patients, specially associated with the utilization of indwelling medical devices, that often serve as a scaffold for biofilm formation. S. epidermidis strains are often multidrug resistant and its association with biofilm formation makes these infections hard to treat. Their remarkable ability to form biofilms is widely regarded as its major pathogenic determinant. Although a significant amount of knowledge on its biofilm formation mechanisms has been achieved, we still do not understand how the species survives when exposed to the host harsh environment during invasion. A previous RNA-seq study highlighted that iron-metabolism associated genes were the most up-regulated bacterial genes upon contact with human blood, which suggested that iron acquisition plays an important role in S. epidermidis biofilm development and escape from the host innate immune system. In this perspective article, we review the available literature on the role of iron metabolism on S. epidermidis pathogenesis and propose that exploiting its dependence on iron could be pursued as a viable therapeutic alternative.
AB - Staphylococcus epidermidis is one of the most important commensal microorganisms of human skin and mucosae. However, this bacterial species is also the cause of severe infections in immunocompromised patients, specially associated with the utilization of indwelling medical devices, that often serve as a scaffold for biofilm formation. S. epidermidis strains are often multidrug resistant and its association with biofilm formation makes these infections hard to treat. Their remarkable ability to form biofilms is widely regarded as its major pathogenic determinant. Although a significant amount of knowledge on its biofilm formation mechanisms has been achieved, we still do not understand how the species survives when exposed to the host harsh environment during invasion. A previous RNA-seq study highlighted that iron-metabolism associated genes were the most up-regulated bacterial genes upon contact with human blood, which suggested that iron acquisition plays an important role in S. epidermidis biofilm development and escape from the host innate immune system. In this perspective article, we review the available literature on the role of iron metabolism on S. epidermidis pathogenesis and propose that exploiting its dependence on iron could be pursued as a viable therapeutic alternative.
KW - Biofilms
KW - Genes, Bacterial
KW - Humans
KW - Iron
KW - Staphylococcal Infections
KW - Staphylococcus epidermidis/genetics
U2 - 10.3389/fcimb.2021.798563
DO - 10.3389/fcimb.2021.798563
M3 - SCORING: Journal article
C2 - 34917520
VL - 11
JO - FRONT CELL INFECT MI
JF - FRONT CELL INFECT MI
SN - 2235-2988
M1 - 798563
ER -