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Fgfr3 Is a Positive Regulator of Osteoblast Expansion and Differentiation During Zebrafish Skull Vault Development

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Fgfr3 Is a Positive Regulator of Osteoblast Expansion and Differentiation During Zebrafish Skull Vault Development. / Dambroise, Emilie; Ktorza, Ivan; Brombin, Alessandro; Abdessalem, Ghaith; Edouard, Joanne; Luka, Marine; Fiedler, Imke; Binder, Olivia; Pelle, Olivier; Patton, E Elizabeth; Busse, Björn; Menager, Mickaël; Sohm, Frederic; Legeai-Mallet, Laurence.

in: J BONE MINER RES, Jahrgang 35, Nr. 9, 09.2020, S. 1782-1797.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Dambroise, E, Ktorza, I, Brombin, A, Abdessalem, G, Edouard, J, Luka, M, Fiedler, I, Binder, O, Pelle, O, Patton, EE, Busse, B, Menager, M, Sohm, F & Legeai-Mallet, L 2020, 'Fgfr3 Is a Positive Regulator of Osteoblast Expansion and Differentiation During Zebrafish Skull Vault Development', J BONE MINER RES, Jg. 35, Nr. 9, S. 1782-1797. https://doi.org/10.1002/jbmr.4042

APA

Dambroise, E., Ktorza, I., Brombin, A., Abdessalem, G., Edouard, J., Luka, M., Fiedler, I., Binder, O., Pelle, O., Patton, E. E., Busse, B., Menager, M., Sohm, F., & Legeai-Mallet, L. (2020). Fgfr3 Is a Positive Regulator of Osteoblast Expansion and Differentiation During Zebrafish Skull Vault Development. J BONE MINER RES, 35(9), 1782-1797. https://doi.org/10.1002/jbmr.4042

Vancouver

Dambroise E, Ktorza I, Brombin A, Abdessalem G, Edouard J, Luka M et al. Fgfr3 Is a Positive Regulator of Osteoblast Expansion and Differentiation During Zebrafish Skull Vault Development. J BONE MINER RES. 2020 Sep;35(9):1782-1797. https://doi.org/10.1002/jbmr.4042

Bibtex

@article{1b06a0e126ce418382b3cbfb08979dd7,
title = "Fgfr3 Is a Positive Regulator of Osteoblast Expansion and Differentiation During Zebrafish Skull Vault Development",
abstract = "Gain or loss-of-function mutations in fibroblast growth factor receptor 3 (FGFR3) result in cranial vault defects highlighting the protein's role in membranous ossification. Zebrafish express high levels of fgfr3 during skull development; in order to study FGFR3's role in cranial vault development, we generated the first fgfr3 loss-of-function zebrafish (fgfr3lof/lof ). The mutant fish exhibited major changes in the craniofacial skeleton, with a lack of sutures, abnormal frontal and parietal bones, and the presence of ectopic bones. Integrated analyses (in vivo imaging and single-cell RNA sequencing of the osteoblast lineage) of zebrafish fgfr3lof/lof revealed a delay in osteoblast expansion and differentiation, together with changes in the extracellular matrix. These findings demonstrate that fgfr3 is a positive regulator of osteogenesis. We conclude that changes in the extracellular matrix within growing bone might impair cell-cell communication, mineralization, and new osteoblast recruitment. {\textcopyright} 2020 American Society for Bone and Mineral Research.",
author = "Emilie Dambroise and Ivan Ktorza and Alessandro Brombin and Ghaith Abdessalem and Joanne Edouard and Marine Luka and Imke Fiedler and Olivia Binder and Olivier Pelle and Patton, {E Elizabeth} and Bj{\"o}rn Busse and Micka{\"e}l Menager and Frederic Sohm and Laurence Legeai-Mallet",
note = "{\textcopyright} 2020 American Society for Bone and Mineral Research.",
year = "2020",
month = sep,
doi = "10.1002/jbmr.4042",
language = "English",
volume = "35",
pages = "1782--1797",
journal = "J BONE MINER RES",
issn = "0884-0431",
publisher = "Wiley-Blackwell",
number = "9",

}

RIS

TY - JOUR

T1 - Fgfr3 Is a Positive Regulator of Osteoblast Expansion and Differentiation During Zebrafish Skull Vault Development

AU - Dambroise, Emilie

AU - Ktorza, Ivan

AU - Brombin, Alessandro

AU - Abdessalem, Ghaith

AU - Edouard, Joanne

AU - Luka, Marine

AU - Fiedler, Imke

AU - Binder, Olivia

AU - Pelle, Olivier

AU - Patton, E Elizabeth

AU - Busse, Björn

AU - Menager, Mickaël

AU - Sohm, Frederic

AU - Legeai-Mallet, Laurence

N1 - © 2020 American Society for Bone and Mineral Research.

PY - 2020/9

Y1 - 2020/9

N2 - Gain or loss-of-function mutations in fibroblast growth factor receptor 3 (FGFR3) result in cranial vault defects highlighting the protein's role in membranous ossification. Zebrafish express high levels of fgfr3 during skull development; in order to study FGFR3's role in cranial vault development, we generated the first fgfr3 loss-of-function zebrafish (fgfr3lof/lof ). The mutant fish exhibited major changes in the craniofacial skeleton, with a lack of sutures, abnormal frontal and parietal bones, and the presence of ectopic bones. Integrated analyses (in vivo imaging and single-cell RNA sequencing of the osteoblast lineage) of zebrafish fgfr3lof/lof revealed a delay in osteoblast expansion and differentiation, together with changes in the extracellular matrix. These findings demonstrate that fgfr3 is a positive regulator of osteogenesis. We conclude that changes in the extracellular matrix within growing bone might impair cell-cell communication, mineralization, and new osteoblast recruitment. © 2020 American Society for Bone and Mineral Research.

AB - Gain or loss-of-function mutations in fibroblast growth factor receptor 3 (FGFR3) result in cranial vault defects highlighting the protein's role in membranous ossification. Zebrafish express high levels of fgfr3 during skull development; in order to study FGFR3's role in cranial vault development, we generated the first fgfr3 loss-of-function zebrafish (fgfr3lof/lof ). The mutant fish exhibited major changes in the craniofacial skeleton, with a lack of sutures, abnormal frontal and parietal bones, and the presence of ectopic bones. Integrated analyses (in vivo imaging and single-cell RNA sequencing of the osteoblast lineage) of zebrafish fgfr3lof/lof revealed a delay in osteoblast expansion and differentiation, together with changes in the extracellular matrix. These findings demonstrate that fgfr3 is a positive regulator of osteogenesis. We conclude that changes in the extracellular matrix within growing bone might impair cell-cell communication, mineralization, and new osteoblast recruitment. © 2020 American Society for Bone and Mineral Research.

U2 - 10.1002/jbmr.4042

DO - 10.1002/jbmr.4042

M3 - SCORING: Journal article

C2 - 32379366

VL - 35

SP - 1782

EP - 1797

JO - J BONE MINER RES

JF - J BONE MINER RES

SN - 0884-0431

IS - 9

ER -