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FGF-4 increases in vitro expansion rate of human adult bone marrow-derived mesenchymal stem cells

Standard

FGF-4 increases in vitro expansion rate of human adult bone marrow-derived mesenchymal stem cells. / Farré, Jordi; Roura, Santiago; Prat-Vidal, Cristina; Soler-Botija, Carolina; Llach, Anna; Molina, Cristina E; Hove-Madsen, Leif; Cairó, Jordi J; Gòdia, Francesc; Bragós, Ramon; Cinca, Juan; Bayes-Genis, Antoni.

in: GROWTH FACTORS, Jahrgang 25, Nr. 2, 04.2007, S. 71-6.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Farré, J, Roura, S, Prat-Vidal, C, Soler-Botija, C, Llach, A, Molina, CE, Hove-Madsen, L, Cairó, JJ, Gòdia, F, Bragós, R, Cinca, J & Bayes-Genis, A 2007, 'FGF-4 increases in vitro expansion rate of human adult bone marrow-derived mesenchymal stem cells', GROWTH FACTORS, Jg. 25, Nr. 2, S. 71-6. https://doi.org/10.1080/08977190701345200

APA

Farré, J., Roura, S., Prat-Vidal, C., Soler-Botija, C., Llach, A., Molina, C. E., Hove-Madsen, L., Cairó, J. J., Gòdia, F., Bragós, R., Cinca, J., & Bayes-Genis, A. (2007). FGF-4 increases in vitro expansion rate of human adult bone marrow-derived mesenchymal stem cells. GROWTH FACTORS, 25(2), 71-6. https://doi.org/10.1080/08977190701345200

Vancouver

Farré J, Roura S, Prat-Vidal C, Soler-Botija C, Llach A, Molina CE et al. FGF-4 increases in vitro expansion rate of human adult bone marrow-derived mesenchymal stem cells. GROWTH FACTORS. 2007 Apr;25(2):71-6. https://doi.org/10.1080/08977190701345200

Bibtex

@article{820a18ff3b2b4f2dba3412786992c897,
title = "FGF-4 increases in vitro expansion rate of human adult bone marrow-derived mesenchymal stem cells",
abstract = "Human bone marrow-derived mesenchymal stem cells (MSCs) exhibit limited in vitro growth. Fibroblast growth factors (FGFs) elicit a variety of biological responses, such as cell proliferation, differentiation and migration. FGF-4 represents one of the FGFs with the highest cell mitogenic activity. We studied the effect of FGF-4 on MSCs growth and pluripotency. MSCs duplication time (Td) was significantly reduced with FGF-4 compared to controls (2.2 +/- 0.2 vs. 4.1 +/- 0.2 days, respectively; p = 0.03) while BMP-2 and SCF-1 did not exert a significant growth effect. MSC expression of surface markers, differentiation into adipogenic and osteogenic lineages, and baseline expression of cardiomyogenic genes were unaffected by FGF-4. In summary, exogenous FGF-4 increases the rate at which MSC proliferate and has no significant effect on MSC pluripotency.",
keywords = "Adipocytes, Bone Marrow Cells, Cell Culture Techniques, Cell Differentiation, Cell Proliferation, Fibroblast Growth Factor 4, Flow Cytometry, Humans, Mesenchymal Stromal Cells, Models, Biological, Myocytes, Cardiac, Osteogenesis, Phenotype, Time Factors, Journal Article, Research Support, Non-U.S. Gov't",
author = "Jordi Farr{\'e} and Santiago Roura and Cristina Prat-Vidal and Carolina Soler-Botija and Anna Llach and Molina, {Cristina E} and Leif Hove-Madsen and Cair{\'o}, {Jordi J} and Francesc G{\`o}dia and Ramon Brag{\'o}s and Juan Cinca and Antoni Bayes-Genis",
year = "2007",
month = apr,
doi = "10.1080/08977190701345200",
language = "English",
volume = "25",
pages = "71--6",
journal = "GROWTH FACTORS",
issn = "0897-7194",
publisher = "informa healthcare",
number = "2",

}

RIS

TY - JOUR

T1 - FGF-4 increases in vitro expansion rate of human adult bone marrow-derived mesenchymal stem cells

AU - Farré, Jordi

AU - Roura, Santiago

AU - Prat-Vidal, Cristina

AU - Soler-Botija, Carolina

AU - Llach, Anna

AU - Molina, Cristina E

AU - Hove-Madsen, Leif

AU - Cairó, Jordi J

AU - Gòdia, Francesc

AU - Bragós, Ramon

AU - Cinca, Juan

AU - Bayes-Genis, Antoni

PY - 2007/4

Y1 - 2007/4

N2 - Human bone marrow-derived mesenchymal stem cells (MSCs) exhibit limited in vitro growth. Fibroblast growth factors (FGFs) elicit a variety of biological responses, such as cell proliferation, differentiation and migration. FGF-4 represents one of the FGFs with the highest cell mitogenic activity. We studied the effect of FGF-4 on MSCs growth and pluripotency. MSCs duplication time (Td) was significantly reduced with FGF-4 compared to controls (2.2 +/- 0.2 vs. 4.1 +/- 0.2 days, respectively; p = 0.03) while BMP-2 and SCF-1 did not exert a significant growth effect. MSC expression of surface markers, differentiation into adipogenic and osteogenic lineages, and baseline expression of cardiomyogenic genes were unaffected by FGF-4. In summary, exogenous FGF-4 increases the rate at which MSC proliferate and has no significant effect on MSC pluripotency.

AB - Human bone marrow-derived mesenchymal stem cells (MSCs) exhibit limited in vitro growth. Fibroblast growth factors (FGFs) elicit a variety of biological responses, such as cell proliferation, differentiation and migration. FGF-4 represents one of the FGFs with the highest cell mitogenic activity. We studied the effect of FGF-4 on MSCs growth and pluripotency. MSCs duplication time (Td) was significantly reduced with FGF-4 compared to controls (2.2 +/- 0.2 vs. 4.1 +/- 0.2 days, respectively; p = 0.03) while BMP-2 and SCF-1 did not exert a significant growth effect. MSC expression of surface markers, differentiation into adipogenic and osteogenic lineages, and baseline expression of cardiomyogenic genes were unaffected by FGF-4. In summary, exogenous FGF-4 increases the rate at which MSC proliferate and has no significant effect on MSC pluripotency.

KW - Adipocytes

KW - Bone Marrow Cells

KW - Cell Culture Techniques

KW - Cell Differentiation

KW - Cell Proliferation

KW - Fibroblast Growth Factor 4

KW - Flow Cytometry

KW - Humans

KW - Mesenchymal Stromal Cells

KW - Models, Biological

KW - Myocytes, Cardiac

KW - Osteogenesis

KW - Phenotype

KW - Time Factors

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1080/08977190701345200

DO - 10.1080/08977190701345200

M3 - SCORING: Journal article

C2 - 17852409

VL - 25

SP - 71

EP - 76

JO - GROWTH FACTORS

JF - GROWTH FACTORS

SN - 0897-7194

IS - 2

ER -