Ferroptosis in health and disease

TY - JOUR

T1 - Ferroptosis in health and disease

AU - Berndt, Carsten

AU - Alborzinia, Hamed

AU - Amen, Vera Skafar

AU - Ayton, Scott

AU - Barayeu, Uladzimir

AU - Bartelt, Alexander

AU - Bayir, Hülya

AU - Bebber, Christina M

AU - Birsoy, Kivanc

AU - Böttcher, Jan P

AU - Brabletz, Simone

AU - Brabletz, Thomas

AU - Brown, Ashley R

AU - Brüne, Bernhard

AU - Bulli, Giorgia

AU - Bruneau, Alix

AU - Chen, Quan

AU - DeNicola, Gina M

AU - Dick, Tobias P

AU - Distéfano, Ayelén

AU - Dixon, Scott J

AU - Engler, Jan B

AU - Esser-von Bieren, Julia

AU - Fedorova, Maria

AU - Friedmann Angeli, José Pedro

AU - Friese, Manuel A

AU - Fuhrmann, Dominic C

AU - García-Sáez, Ana J

AU - Garbowicz, Karolina

AU - Götz, Magdalena

AU - Gu, Wei

AU - Hammerich, Linda

AU - Hassannia, Behrouz

AU - Jiang, Xuejun

AU - Jeridi, Aicha

AU - Kang, Yun Pyo

AU - Kagan, Valerian E

AU - Konrad, David B

AU - Kotschi, Stefan

AU - Lei, Peng

AU - Le Tertre, Marlène

AU - Lev, Sima

AU - Liang, Deguang

AU - Linkermann, Andreas

AU - Lohr, Carolin

AU - Lorenz, Svenja

AU - Luedde, Tom

AU - Methner, Axel

AU - Michalke, Bernhard

AU - Milton, Anna V

AU - Min, Junxia

AU - Mishima, Eikan

AU - Müller, Sebastian

AU - Motohashi, Hozumi

AU - Muckenthaler, Martina U

AU - Murakami, Shohei

AU - Olzmann, James A

AU - Pagnussat, Gabriela

AU - Pan, Zijan

AU - Papagiannakopoulos, Thales

AU - Pedrera Puentes, Lohans

AU - Pratt, Derek A

AU - Proneth, Bettina

AU - Ramsauer, Lukas

AU - Rodriguez, Raphael

AU - Saito, Yoshiro

AU - Schmidt, Felix

AU - Schmitt, Carina

AU - Schulze, Almut

AU - Schwab, Annemarie

AU - Schwantes, Anna

AU - Soula, Mariluz

AU - Spitzlberger, Benedikt

AU - Stockwell, Brent R

AU - Thewes, Leonie

AU - Thorn-Seshold, Oliver

AU - Toyokuni, Shinya

AU - Tonnus, Wulf

AU - Trumpp, Andreas

AU - Vandenabeele, Peter

AU - Vanden Berghe, Tom

AU - Venkataramani, Vivek

AU - Vogel, Felix C E

AU - von Karstedt, Silvia

AU - Wang, Fudi

AU - Westermann, Frank

AU - Wientjens, Chantal

AU - Wilhelm, Christoph

AU - Wölk, Michele

AU - Wu, Katherine

AU - Yang, Xin

AU - Yu, Fan

AU - Zou, Yilong

AU - Conrad, Marcus

N1 - Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.

PY - 2024/9

Y1 - 2024/9

N2 - Ferroptosis is a pervasive non-apoptotic form of cell death highly relevant in various degenerative diseases and malignancies. The hallmark of ferroptosis is uncontrolled and overwhelming peroxidation of polyunsaturated fatty acids contained in membrane phospholipids, which eventually leads to rupture of the plasma membrane. Ferroptosis is unique in that it is essentially a spontaneous, uncatalyzed chemical process based on perturbed iron and redox homeostasis contributing to the cell death process, but that it is nonetheless modulated by many metabolic nodes that impinge on the cells' susceptibility to ferroptosis. Among the various nodes affecting ferroptosis sensitivity, several have emerged as promising candidates for pharmacological intervention, rendering ferroptosis-related proteins attractive targets for the treatment of numerous currently incurable diseases. Herein, the current members of a Germany-wide research consortium focusing on ferroptosis research, as well as key external experts in ferroptosis who have made seminal contributions to this rapidly growing and exciting field of research, have gathered to provide a comprehensive, state-of-the-art review on ferroptosis. Specific topics include: basic mechanisms, in vivo relevance, specialized methodologies, chemical and pharmacological tools, and the potential contribution of ferroptosis to disease etiopathology and progression. We hope that this article will not only provide established scientists and newcomers to the field with an overview of the multiple facets of ferroptosis, but also encourage additional efforts to characterize further molecular pathways modulating ferroptosis, with the ultimate goal to develop novel pharmacotherapies to tackle the various diseases associated with - or caused by - ferroptosis.

AB - Ferroptosis is a pervasive non-apoptotic form of cell death highly relevant in various degenerative diseases and malignancies. The hallmark of ferroptosis is uncontrolled and overwhelming peroxidation of polyunsaturated fatty acids contained in membrane phospholipids, which eventually leads to rupture of the plasma membrane. Ferroptosis is unique in that it is essentially a spontaneous, uncatalyzed chemical process based on perturbed iron and redox homeostasis contributing to the cell death process, but that it is nonetheless modulated by many metabolic nodes that impinge on the cells' susceptibility to ferroptosis. Among the various nodes affecting ferroptosis sensitivity, several have emerged as promising candidates for pharmacological intervention, rendering ferroptosis-related proteins attractive targets for the treatment of numerous currently incurable diseases. Herein, the current members of a Germany-wide research consortium focusing on ferroptosis research, as well as key external experts in ferroptosis who have made seminal contributions to this rapidly growing and exciting field of research, have gathered to provide a comprehensive, state-of-the-art review on ferroptosis. Specific topics include: basic mechanisms, in vivo relevance, specialized methodologies, chemical and pharmacological tools, and the potential contribution of ferroptosis to disease etiopathology and progression. We hope that this article will not only provide established scientists and newcomers to the field with an overview of the multiple facets of ferroptosis, but also encourage additional efforts to characterize further molecular pathways modulating ferroptosis, with the ultimate goal to develop novel pharmacotherapies to tackle the various diseases associated with - or caused by - ferroptosis.

U2 - 10.1016/j.redox.2024.103211

DO - 10.1016/j.redox.2024.103211

M3 - SCORING: Review article

C2 - 38908072

VL - 75

JO - REDOX BIOL

JF - REDOX BIOL

SN - 2213-2317

M1 - 103211

ER -