Feel the force: Podosomes in mechanosensing
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Feel the force: Podosomes in mechanosensing. / Linder, Stefan; Wiesner, Christiane.
in: EXP CELL RES, Jahrgang 343, Nr. 1, 10.04.2016, S. 67-72.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Feel the force: Podosomes in mechanosensing
AU - Linder, Stefan
AU - Wiesner, Christiane
N1 - Copyright © 2015. Published by Elsevier Inc.
PY - 2016/4/10
Y1 - 2016/4/10
N2 - Cells interact with their environment through highly localized contact structures. Podosomes represent a subgroup of cell-matrix contacts, which is especially prominent in cells of the monocytic lineage such as monocytes, macrophages and dendritic cells, but also in a variety of other cell types. Comparable to other adhesion structures, podosomes feature a complex architecture, which forms the basis for their extensive repertoire of sensory and effector functions. These functions are mainly linked to interactions with the extracellular matrix and comprise well known properties such as cell-matrix adhesion and extracellular matrix degradation. A more recent discovery is the ability of podosomes to act as mechanosensory devices, by detecting rigidity and topography of the substratum. In this review, we focus especially on the molecular events involved in mechanosensing by podosomes, the structural elements of podosomes that enable this function, as well as the intra- and extracellular signals generated downstream of podosome mechanosensing.
AB - Cells interact with their environment through highly localized contact structures. Podosomes represent a subgroup of cell-matrix contacts, which is especially prominent in cells of the monocytic lineage such as monocytes, macrophages and dendritic cells, but also in a variety of other cell types. Comparable to other adhesion structures, podosomes feature a complex architecture, which forms the basis for their extensive repertoire of sensory and effector functions. These functions are mainly linked to interactions with the extracellular matrix and comprise well known properties such as cell-matrix adhesion and extracellular matrix degradation. A more recent discovery is the ability of podosomes to act as mechanosensory devices, by detecting rigidity and topography of the substratum. In this review, we focus especially on the molecular events involved in mechanosensing by podosomes, the structural elements of podosomes that enable this function, as well as the intra- and extracellular signals generated downstream of podosome mechanosensing.
U2 - 10.1016/j.yexcr.2015.11.026
DO - 10.1016/j.yexcr.2015.11.026
M3 - SCORING: Journal article
C2 - 26658516
VL - 343
SP - 67
EP - 72
JO - EXP CELL RES
JF - EXP CELL RES
SN - 0014-4827
IS - 1
ER -