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Feasibility of assessing pulmonary blood volume using C-arm CT during transpulmonary chemoperfusion and chemoembolization in primary and secondary lung tumours

Standard

Feasibility of assessing pulmonary blood volume using C-arm CT during transpulmonary chemoperfusion and chemoembolization in primary and secondary lung tumours. / Vogl, Thomas J; Nour-Eldin, Nour-Eldin A; Naguib, Nagy N N; Lehnert, Thomas; Ackermann, Hanns; Hammerstingl, Renate; Hezel, Marcus.

in: BRIT J RADIOL, Jahrgang 89, Nr. 1062, 06.2016, S. 20150244.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Vogl, TJ, Nour-Eldin, N-EA, Naguib, NNN, Lehnert, T, Ackermann, H, Hammerstingl, R & Hezel, M 2016, 'Feasibility of assessing pulmonary blood volume using C-arm CT during transpulmonary chemoperfusion and chemoembolization in primary and secondary lung tumours', BRIT J RADIOL, Jg. 89, Nr. 1062, S. 20150244. https://doi.org/10.1259/bjr.20150244

APA

Vogl, T. J., Nour-Eldin, N-E. A., Naguib, N. N. N., Lehnert, T., Ackermann, H., Hammerstingl, R., & Hezel, M. (2016). Feasibility of assessing pulmonary blood volume using C-arm CT during transpulmonary chemoperfusion and chemoembolization in primary and secondary lung tumours. BRIT J RADIOL, 89(1062), 20150244. https://doi.org/10.1259/bjr.20150244

Vancouver

Vogl TJ, Nour-Eldin N-EA, Naguib NNN, Lehnert T, Ackermann H, Hammerstingl R et al. Feasibility of assessing pulmonary blood volume using C-arm CT during transpulmonary chemoperfusion and chemoembolization in primary and secondary lung tumours. BRIT J RADIOL. 2016 Jun;89(1062):20150244. https://doi.org/10.1259/bjr.20150244

Bibtex

@article{afd306101b05487ab3c3978e030e5d88,
title = "Feasibility of assessing pulmonary blood volume using C-arm CT during transpulmonary chemoperfusion and chemoembolization in primary and secondary lung tumours",
abstract = "OBJECTIVE: Assessment of parenchymal blood volume (PBV) of primary and secondary pulmonary malignancies by using a C-arm CT, regarding its role in detecting early functional response to transpulmonary chemoembolization (TPCE) and clinical practicability.METHODS: 21 patients with a mean age of 56.77 years, who were assigned to TPCE during their palliative treatment, were included. PBV and the diameter of tumours were analyzed. PBV maps were calculated from three-dimensional CT-angiographic (3D-CTA) data sets. Imaging was performed on a flat detector, C-arm CT. Groups of response were classified according to the criteria of the response evaluation criteria in solid tumours. Statistically significant differences were determined and Pearson's regression analysis correlated PBV and diameter as parameters of response to treatment.RESULTS: During 4.91 sessions, median diameter increased 18.18% (p > 0.05) and PBV reduced 39.62% (p > 0.05). Functional and imaging response per tumour was statistical significantly different (p ≤ 0.05). Correlation coefficient was r = 0.058. 2/41 tumours showed partial response; 31/41 tumours showed stable disease; and 8/41 tumours showed progressive disease. The highest pre-treatment PBV values were measured in decreasing tumours (206.93 ml l(-1)), and the lowest values were measured in increasing tumours (60.17 ml l(-1); p > 0.05). The lowest values were also measured in lung cancer (53.02 ml l(-1)) that was significantly different to uterine leiomyosarcoma (103.31 ml l(-1)) and renal cell cancer (113.14 ml l(-1); p ≤ 0.05).CONCLUSION: Assessment of PBV maps by using 3D-CTA image data is feasible in the clinical routine. PBV shows a stronger response to TPCE treatment than measurement in diameter and should be considered as a response parameter for early detection.ADVANCES IN KNOWLEDGE: Assessment of PBV using C-arm CT during TPCE is a feasible technique. Assessment of PBV might be useful in assessing response to treatment.",
keywords = "Adult, Aged, Blood Volume, Chemoembolization, Therapeutic, Computed Tomography Angiography, Drug Monitoring, Feasibility Studies, Female, Humans, Lung Neoplasms, Male, Middle Aged, Neovascularization, Pathologic, Radiography, Interventional, Retrospective Studies, Treatment Outcome, Journal Article",
author = "Vogl, {Thomas J} and Nour-Eldin, {Nour-Eldin A} and Naguib, {Nagy N N} and Thomas Lehnert and Hanns Ackermann and Renate Hammerstingl and Marcus Hezel",
year = "2016",
month = jun,
doi = "10.1259/bjr.20150244",
language = "English",
volume = "89",
pages = "20150244",
journal = "BRIT J RADIOL",
issn = "0007-1285",
publisher = "British Institute of Radiology",
number = "1062",

}

RIS

TY - JOUR

T1 - Feasibility of assessing pulmonary blood volume using C-arm CT during transpulmonary chemoperfusion and chemoembolization in primary and secondary lung tumours

AU - Vogl, Thomas J

AU - Nour-Eldin, Nour-Eldin A

AU - Naguib, Nagy N N

AU - Lehnert, Thomas

AU - Ackermann, Hanns

AU - Hammerstingl, Renate

AU - Hezel, Marcus

PY - 2016/6

Y1 - 2016/6

N2 - OBJECTIVE: Assessment of parenchymal blood volume (PBV) of primary and secondary pulmonary malignancies by using a C-arm CT, regarding its role in detecting early functional response to transpulmonary chemoembolization (TPCE) and clinical practicability.METHODS: 21 patients with a mean age of 56.77 years, who were assigned to TPCE during their palliative treatment, were included. PBV and the diameter of tumours were analyzed. PBV maps were calculated from three-dimensional CT-angiographic (3D-CTA) data sets. Imaging was performed on a flat detector, C-arm CT. Groups of response were classified according to the criteria of the response evaluation criteria in solid tumours. Statistically significant differences were determined and Pearson's regression analysis correlated PBV and diameter as parameters of response to treatment.RESULTS: During 4.91 sessions, median diameter increased 18.18% (p > 0.05) and PBV reduced 39.62% (p > 0.05). Functional and imaging response per tumour was statistical significantly different (p ≤ 0.05). Correlation coefficient was r = 0.058. 2/41 tumours showed partial response; 31/41 tumours showed stable disease; and 8/41 tumours showed progressive disease. The highest pre-treatment PBV values were measured in decreasing tumours (206.93 ml l(-1)), and the lowest values were measured in increasing tumours (60.17 ml l(-1); p > 0.05). The lowest values were also measured in lung cancer (53.02 ml l(-1)) that was significantly different to uterine leiomyosarcoma (103.31 ml l(-1)) and renal cell cancer (113.14 ml l(-1); p ≤ 0.05).CONCLUSION: Assessment of PBV maps by using 3D-CTA image data is feasible in the clinical routine. PBV shows a stronger response to TPCE treatment than measurement in diameter and should be considered as a response parameter for early detection.ADVANCES IN KNOWLEDGE: Assessment of PBV using C-arm CT during TPCE is a feasible technique. Assessment of PBV might be useful in assessing response to treatment.

AB - OBJECTIVE: Assessment of parenchymal blood volume (PBV) of primary and secondary pulmonary malignancies by using a C-arm CT, regarding its role in detecting early functional response to transpulmonary chemoembolization (TPCE) and clinical practicability.METHODS: 21 patients with a mean age of 56.77 years, who were assigned to TPCE during their palliative treatment, were included. PBV and the diameter of tumours were analyzed. PBV maps were calculated from three-dimensional CT-angiographic (3D-CTA) data sets. Imaging was performed on a flat detector, C-arm CT. Groups of response were classified according to the criteria of the response evaluation criteria in solid tumours. Statistically significant differences were determined and Pearson's regression analysis correlated PBV and diameter as parameters of response to treatment.RESULTS: During 4.91 sessions, median diameter increased 18.18% (p > 0.05) and PBV reduced 39.62% (p > 0.05). Functional and imaging response per tumour was statistical significantly different (p ≤ 0.05). Correlation coefficient was r = 0.058. 2/41 tumours showed partial response; 31/41 tumours showed stable disease; and 8/41 tumours showed progressive disease. The highest pre-treatment PBV values were measured in decreasing tumours (206.93 ml l(-1)), and the lowest values were measured in increasing tumours (60.17 ml l(-1); p > 0.05). The lowest values were also measured in lung cancer (53.02 ml l(-1)) that was significantly different to uterine leiomyosarcoma (103.31 ml l(-1)) and renal cell cancer (113.14 ml l(-1); p ≤ 0.05).CONCLUSION: Assessment of PBV maps by using 3D-CTA image data is feasible in the clinical routine. PBV shows a stronger response to TPCE treatment than measurement in diameter and should be considered as a response parameter for early detection.ADVANCES IN KNOWLEDGE: Assessment of PBV using C-arm CT during TPCE is a feasible technique. Assessment of PBV might be useful in assessing response to treatment.

KW - Adult

KW - Aged

KW - Blood Volume

KW - Chemoembolization, Therapeutic

KW - Computed Tomography Angiography

KW - Drug Monitoring

KW - Feasibility Studies

KW - Female

KW - Humans

KW - Lung Neoplasms

KW - Male

KW - Middle Aged

KW - Neovascularization, Pathologic

KW - Radiography, Interventional

KW - Retrospective Studies

KW - Treatment Outcome

KW - Journal Article

U2 - 10.1259/bjr.20150244

DO - 10.1259/bjr.20150244

M3 - SCORING: Journal article

C2 - 27046514

VL - 89

SP - 20150244

JO - BRIT J RADIOL

JF - BRIT J RADIOL

SN - 0007-1285

IS - 1062

ER -