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Feasibility and outcome of radical prostatectomy following inductive neoadjuvant therapy in patients with suspicion of rectal infiltration

Standard

Feasibility and outcome of radical prostatectomy following inductive neoadjuvant therapy in patients with suspicion of rectal infiltration. / Hoeh, Benedikt; Preisser, Felix; Wenzel, Mike; Humke, Clara; Wittler, Clarissa; Köllermann, Jens; Bodelle, Boris; Bernatz, Simon; Steuber, Thomas; Tilki, Derya; Graefen, Markus; Karakiewicz, Pierre I; Becker, Andreas; Kluth, Luis A; Chun, Felix K H; Mandel, Philipp.

in: UROL ONCOL-SEMIN ORI, Jahrgang 40, Nr. 2, 02.2022, S. 59.e7-59.e12.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Hoeh, B, Preisser, F, Wenzel, M, Humke, C, Wittler, C, Köllermann, J, Bodelle, B, Bernatz, S, Steuber, T, Tilki, D, Graefen, M, Karakiewicz, PI, Becker, A, Kluth, LA, Chun, FKH & Mandel, P 2022, 'Feasibility and outcome of radical prostatectomy following inductive neoadjuvant therapy in patients with suspicion of rectal infiltration', UROL ONCOL-SEMIN ORI, Jg. 40, Nr. 2, S. 59.e7-59.e12. https://doi.org/10.1016/j.urolonc.2021.07.028

APA

Hoeh, B., Preisser, F., Wenzel, M., Humke, C., Wittler, C., Köllermann, J., Bodelle, B., Bernatz, S., Steuber, T., Tilki, D., Graefen, M., Karakiewicz, P. I., Becker, A., Kluth, L. A., Chun, F. K. H., & Mandel, P. (2022). Feasibility and outcome of radical prostatectomy following inductive neoadjuvant therapy in patients with suspicion of rectal infiltration. UROL ONCOL-SEMIN ORI, 40(2), 59.e7-59.e12. https://doi.org/10.1016/j.urolonc.2021.07.028

Vancouver

Hoeh B, Preisser F, Wenzel M, Humke C, Wittler C, Köllermann J et al. Feasibility and outcome of radical prostatectomy following inductive neoadjuvant therapy in patients with suspicion of rectal infiltration. UROL ONCOL-SEMIN ORI. 2022 Feb;40(2):59.e7-59.e12. https://doi.org/10.1016/j.urolonc.2021.07.028

Bibtex

@article{6f8a69accb0944769427392cb2305939,
title = "Feasibility and outcome of radical prostatectomy following inductive neoadjuvant therapy in patients with suspicion of rectal infiltration",
abstract = "OBJECTIVE: To determine the feasibility and outcome of radical prostatectomy (RP) following neoadjuvant therapy (NAT) in patients with initial inoperable, rectum-infiltrating cT4 prostate cancer (PCa).METHODS: From 01/2018 to 12/2020, 26 patients with clinical (DRE) or radiographical (mpMRI) suspicion of rectum infiltrating PCa at diagnosis and NAT prior to RP were retrospectively identified from our prospective institutional database. Two patients were still inoperable after NAT. Downsizing was administered for at least 20 weeks and RP was performed after excluding ongoing rectal infiltration.RESULTS: At diagnosis, median PSA was 42.5 ng/ml (IQR: 23.0-66.1). Inductive NAT consisted of androgen deprivation therapy (ADT) in combination with chemotherapy (n = 9) or without chemotherapy (n = 14). Median preoperative PSA was 0.93 ng/ml (IQR: 0.24-0.40). Median time from NAT to RP was 6 months (IQR: 5-7). Two patients were still inoperable after NAT. Of 24 patients undergoing RP, abortion of surgery due to inoperability was observed in 2 patients (8.4%), demonstrating a total failure rate of NAT in 4 out of 26 patients (15.4%). One patient suffered a rectal injury with consecutive colostomy (4.2%). No Clavien-Dindo complication Grade IV or V were observed. Urinary continence was achieved in 16 patients (84.2%). Sufficient erection for sexual intercourse was present in 2 patients (10.5%). All patients received adjuvant ADT with or without radiation therapy. Median PSA at 13 months was 0.08 ng/ml (IQR: 0.01-0.74).CONCLUSION: RP of initially rectum infiltrating PCa is feasible and safe after inductive NAT, however complications rates tend to be higher compared to standard RP.",
author = "Benedikt Hoeh and Felix Preisser and Mike Wenzel and Clara Humke and Clarissa Wittler and Jens K{\"o}llermann and Boris Bodelle and Simon Bernatz and Thomas Steuber and Derya Tilki and Markus Graefen and Karakiewicz, {Pierre I} and Andreas Becker and Kluth, {Luis A} and Chun, {Felix K H} and Philipp Mandel",
note = "Copyright {\textcopyright} 2021 Elsevier Inc. All rights reserved.",
year = "2022",
month = feb,
doi = "10.1016/j.urolonc.2021.07.028",
language = "English",
volume = "40",
pages = "59.e7--59.e12",
journal = "UROL ONCOL-SEMIN ORI",
issn = "1078-1439",
publisher = "Elsevier Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Feasibility and outcome of radical prostatectomy following inductive neoadjuvant therapy in patients with suspicion of rectal infiltration

AU - Hoeh, Benedikt

AU - Preisser, Felix

AU - Wenzel, Mike

AU - Humke, Clara

AU - Wittler, Clarissa

AU - Köllermann, Jens

AU - Bodelle, Boris

AU - Bernatz, Simon

AU - Steuber, Thomas

AU - Tilki, Derya

AU - Graefen, Markus

AU - Karakiewicz, Pierre I

AU - Becker, Andreas

AU - Kluth, Luis A

AU - Chun, Felix K H

AU - Mandel, Philipp

N1 - Copyright © 2021 Elsevier Inc. All rights reserved.

PY - 2022/2

Y1 - 2022/2

N2 - OBJECTIVE: To determine the feasibility and outcome of radical prostatectomy (RP) following neoadjuvant therapy (NAT) in patients with initial inoperable, rectum-infiltrating cT4 prostate cancer (PCa).METHODS: From 01/2018 to 12/2020, 26 patients with clinical (DRE) or radiographical (mpMRI) suspicion of rectum infiltrating PCa at diagnosis and NAT prior to RP were retrospectively identified from our prospective institutional database. Two patients were still inoperable after NAT. Downsizing was administered for at least 20 weeks and RP was performed after excluding ongoing rectal infiltration.RESULTS: At diagnosis, median PSA was 42.5 ng/ml (IQR: 23.0-66.1). Inductive NAT consisted of androgen deprivation therapy (ADT) in combination with chemotherapy (n = 9) or without chemotherapy (n = 14). Median preoperative PSA was 0.93 ng/ml (IQR: 0.24-0.40). Median time from NAT to RP was 6 months (IQR: 5-7). Two patients were still inoperable after NAT. Of 24 patients undergoing RP, abortion of surgery due to inoperability was observed in 2 patients (8.4%), demonstrating a total failure rate of NAT in 4 out of 26 patients (15.4%). One patient suffered a rectal injury with consecutive colostomy (4.2%). No Clavien-Dindo complication Grade IV or V were observed. Urinary continence was achieved in 16 patients (84.2%). Sufficient erection for sexual intercourse was present in 2 patients (10.5%). All patients received adjuvant ADT with or without radiation therapy. Median PSA at 13 months was 0.08 ng/ml (IQR: 0.01-0.74).CONCLUSION: RP of initially rectum infiltrating PCa is feasible and safe after inductive NAT, however complications rates tend to be higher compared to standard RP.

AB - OBJECTIVE: To determine the feasibility and outcome of radical prostatectomy (RP) following neoadjuvant therapy (NAT) in patients with initial inoperable, rectum-infiltrating cT4 prostate cancer (PCa).METHODS: From 01/2018 to 12/2020, 26 patients with clinical (DRE) or radiographical (mpMRI) suspicion of rectum infiltrating PCa at diagnosis and NAT prior to RP were retrospectively identified from our prospective institutional database. Two patients were still inoperable after NAT. Downsizing was administered for at least 20 weeks and RP was performed after excluding ongoing rectal infiltration.RESULTS: At diagnosis, median PSA was 42.5 ng/ml (IQR: 23.0-66.1). Inductive NAT consisted of androgen deprivation therapy (ADT) in combination with chemotherapy (n = 9) or without chemotherapy (n = 14). Median preoperative PSA was 0.93 ng/ml (IQR: 0.24-0.40). Median time from NAT to RP was 6 months (IQR: 5-7). Two patients were still inoperable after NAT. Of 24 patients undergoing RP, abortion of surgery due to inoperability was observed in 2 patients (8.4%), demonstrating a total failure rate of NAT in 4 out of 26 patients (15.4%). One patient suffered a rectal injury with consecutive colostomy (4.2%). No Clavien-Dindo complication Grade IV or V were observed. Urinary continence was achieved in 16 patients (84.2%). Sufficient erection for sexual intercourse was present in 2 patients (10.5%). All patients received adjuvant ADT with or without radiation therapy. Median PSA at 13 months was 0.08 ng/ml (IQR: 0.01-0.74).CONCLUSION: RP of initially rectum infiltrating PCa is feasible and safe after inductive NAT, however complications rates tend to be higher compared to standard RP.

U2 - 10.1016/j.urolonc.2021.07.028

DO - 10.1016/j.urolonc.2021.07.028

M3 - SCORING: Journal article

C2 - 34456124

VL - 40

SP - 59.e7-59.e12

JO - UROL ONCOL-SEMIN ORI

JF - UROL ONCOL-SEMIN ORI

SN - 1078-1439

IS - 2

ER -