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Fast recruitment of recurrent inhibition in the cat visual cortex.

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Fast recruitment of recurrent inhibition in the cat visual cortex. / Ohana, Ora; Portner, Hanspeter; Martin, Kevan A C.

in: PLOS ONE, Jahrgang 7, Nr. 7, 7, 2012, S. 40601.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Ohana, O, Portner, H & Martin, KAC 2012, 'Fast recruitment of recurrent inhibition in the cat visual cortex.', PLOS ONE, Jg. 7, Nr. 7, 7, S. 40601. https://doi.org/10.1371/journal.pone.0040601

APA

Ohana, O., Portner, H., & Martin, K. A. C. (2012). Fast recruitment of recurrent inhibition in the cat visual cortex. PLOS ONE, 7(7), 40601. [7]. https://doi.org/10.1371/journal.pone.0040601

Vancouver

Ohana O, Portner H, Martin KAC. Fast recruitment of recurrent inhibition in the cat visual cortex. PLOS ONE. 2012;7(7):40601. 7. https://doi.org/10.1371/journal.pone.0040601

Bibtex

@article{f25df959175140cd87b99d35d4a45c07,
title = "Fast recruitment of recurrent inhibition in the cat visual cortex.",
abstract = "Neurons of the same column in L4 of the cat visual cortex are likely to share the same sensory input from the same region of the visual field. Using visually-guided patch clamp recordings we investigated the biophysical properties of the synapses of neighboring layer 4 neurons. We recorded synaptic connections between all types of excitatory and inhibitory neurons in L4. The E-E, E-I, and I-E connections had moderate CVs and failure rates. However, E-I connections had larger amplitudes, faster rise-times, and shorter latencies. Identification of the sites of putative synaptic contacts together with compartmental simulations on 3D reconstructed cells, suggested that E-I synapses tended to be located on proximal dendritic branches, which would explain their larger EPSP amplitudes and faster kinetics. Excitatory and inhibitory synapses were located at the same distance on distal dendrites of excitatory neurons. We hypothesize that this co-localization and the fast recruitment of local inhibition provides an efficient means of modulating excitation in a precisely timed way.",
keywords = "Animals, Male, Female, *Models, Neurological, Dendrites/*physiology, Nerve Net/*physiology, Cats, Synapses/*physiology, Visual Cortex/cytology/*physiology, Animals, Male, Female, *Models, Neurological, Dendrites/*physiology, Nerve Net/*physiology, Cats, Synapses/*physiology, Visual Cortex/cytology/*physiology",
author = "Ora Ohana and Hanspeter Portner and Martin, {Kevan A C}",
year = "2012",
doi = "10.1371/journal.pone.0040601",
language = "English",
volume = "7",
pages = "40601",
journal = "PLOS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "7",

}

RIS

TY - JOUR

T1 - Fast recruitment of recurrent inhibition in the cat visual cortex.

AU - Ohana, Ora

AU - Portner, Hanspeter

AU - Martin, Kevan A C

PY - 2012

Y1 - 2012

N2 - Neurons of the same column in L4 of the cat visual cortex are likely to share the same sensory input from the same region of the visual field. Using visually-guided patch clamp recordings we investigated the biophysical properties of the synapses of neighboring layer 4 neurons. We recorded synaptic connections between all types of excitatory and inhibitory neurons in L4. The E-E, E-I, and I-E connections had moderate CVs and failure rates. However, E-I connections had larger amplitudes, faster rise-times, and shorter latencies. Identification of the sites of putative synaptic contacts together with compartmental simulations on 3D reconstructed cells, suggested that E-I synapses tended to be located on proximal dendritic branches, which would explain their larger EPSP amplitudes and faster kinetics. Excitatory and inhibitory synapses were located at the same distance on distal dendrites of excitatory neurons. We hypothesize that this co-localization and the fast recruitment of local inhibition provides an efficient means of modulating excitation in a precisely timed way.

AB - Neurons of the same column in L4 of the cat visual cortex are likely to share the same sensory input from the same region of the visual field. Using visually-guided patch clamp recordings we investigated the biophysical properties of the synapses of neighboring layer 4 neurons. We recorded synaptic connections between all types of excitatory and inhibitory neurons in L4. The E-E, E-I, and I-E connections had moderate CVs and failure rates. However, E-I connections had larger amplitudes, faster rise-times, and shorter latencies. Identification of the sites of putative synaptic contacts together with compartmental simulations on 3D reconstructed cells, suggested that E-I synapses tended to be located on proximal dendritic branches, which would explain their larger EPSP amplitudes and faster kinetics. Excitatory and inhibitory synapses were located at the same distance on distal dendrites of excitatory neurons. We hypothesize that this co-localization and the fast recruitment of local inhibition provides an efficient means of modulating excitation in a precisely timed way.

KW - Animals

KW - Male

KW - Female

KW - Models, Neurological

KW - Dendrites/physiology

KW - Nerve Net/physiology

KW - Cats

KW - Synapses/physiology

KW - Visual Cortex/cytology/physiology

KW - Animals

KW - Male

KW - Female

KW - Models, Neurological

KW - Dendrites/physiology

KW - Nerve Net/physiology

KW - Cats

KW - Synapses/physiology

KW - Visual Cortex/cytology/physiology

U2 - 10.1371/journal.pone.0040601

DO - 10.1371/journal.pone.0040601

M3 - SCORING: Journal article

VL - 7

SP - 40601

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 7

M1 - 7

ER -