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Factors associated with depressive mood at the onset of multiple sclerosis - an analysis of 781 patients of the German NationMS cohort

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Factors associated with depressive mood at the onset of multiple sclerosis - an analysis of 781 patients of the German NationMS cohort. / Salmen, Anke; Hoepner, Robert; Fleischer, Vinzenz; Heldt, Milena; Gisevius, Barbara; Motte, Jeremias; Ruprecht, Klemens; Schneider, Ruth; Fisse, Anna Lena; Grüter, Thomas; Lukas, Carsten; Berthele, Achim; Giglhuber, Katrin; Flaskamp, Martina; Mühlau, Mark; Kirschke, Jan; Bittner, Stefan; Groppa, Sergiu; Lüssi, Felix; Bayas, Antonios; Meuth, Sven; Heesen, Cristoph; Trebst, Corinna; Wildemann, Brigitte; Then Bergh, Florian; Antony, Gisela; Kümpfel, Tania; Paul, Friedemann; Nischwitz, Sandra; Tumani, Hayrettin; Zettl, Uwe; Hemmer, Bernhard; Wiendl, Heinz; Zipp, Frauke; Gold, Ralf.

in: THER ADV NEUROL DISO, Jahrgang 16, 2023, S. 17562864231197309.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Salmen, A, Hoepner, R, Fleischer, V, Heldt, M, Gisevius, B, Motte, J, Ruprecht, K, Schneider, R, Fisse, AL, Grüter, T, Lukas, C, Berthele, A, Giglhuber, K, Flaskamp, M, Mühlau, M, Kirschke, J, Bittner, S, Groppa, S, Lüssi, F, Bayas, A, Meuth, S, Heesen, C, Trebst, C, Wildemann, B, Then Bergh, F, Antony, G, Kümpfel, T, Paul, F, Nischwitz, S, Tumani, H, Zettl, U, Hemmer, B, Wiendl, H, Zipp, F & Gold, R 2023, 'Factors associated with depressive mood at the onset of multiple sclerosis - an analysis of 781 patients of the German NationMS cohort', THER ADV NEUROL DISO, Jg. 16, S. 17562864231197309. https://doi.org/10.1177/17562864231197309

APA

Salmen, A., Hoepner, R., Fleischer, V., Heldt, M., Gisevius, B., Motte, J., Ruprecht, K., Schneider, R., Fisse, A. L., Grüter, T., Lukas, C., Berthele, A., Giglhuber, K., Flaskamp, M., Mühlau, M., Kirschke, J., Bittner, S., Groppa, S., Lüssi, F., ... Gold, R. (2023). Factors associated with depressive mood at the onset of multiple sclerosis - an analysis of 781 patients of the German NationMS cohort. THER ADV NEUROL DISO, 16, 17562864231197309. https://doi.org/10.1177/17562864231197309

Vancouver

Salmen A, Hoepner R, Fleischer V, Heldt M, Gisevius B, Motte J et al. Factors associated with depressive mood at the onset of multiple sclerosis - an analysis of 781 patients of the German NationMS cohort. THER ADV NEUROL DISO. 2023;16:17562864231197309. https://doi.org/10.1177/17562864231197309

Bibtex

@article{07dbacc15571464f961fe2258efb7f1f,
title = "Factors associated with depressive mood at the onset of multiple sclerosis - an analysis of 781 patients of the German NationMS cohort",
abstract = "BACKGROUND: Depression has a major impact on the disease burden of multiple sclerosis (MS). Analyses of overlapping MS and depression risk factors [smoking, vitamin D (25-OH-VD) and Epstein-Barr virus (EBV) infection] and sex, age, disease characteristics and neuroimaging features associated with depressive symptoms in early MS are scarce.OBJECTIVES: To assess an association of MS risk factors with depressive symptoms within the German NationMS cohort.DESIGN: Cross-sectional analysis within a multicenter observational study.METHODS: Baseline data of n = 781 adults with newly diagnosed clinically isolated syndrome or relapsing-remitting MS qualified for analysis. Global and region-specific magnetic resonance imaging (MRI)-volumetry parameters were available for n = 327 patients. Association of demographic factors, MS characteristics and risk factors [sex, age, smoking, disease course, presence of current relapse, expanded disability status scale (EDSS) score, fatigue (fatigue scale motor cognition), 25-OH-VD serum concentration, EBV nuclear antigen-1 IgG (EBNA1-IgG) serum levels] and depressive symptoms (Beck Depression Inventory-II, BDI-II) was tested as a primary outcome by multivariable linear regression. Non-parametric correlation and group comparison were performed for associations of MRI parameters and depressive symptoms.RESULTS: Mean age was 34.3 years (95% confidence interval: 33.6-35.0). The female-to-male ratio was 2.3:1. At least minimal depressive symptoms (BDI-II > 8) were present in n = 256 (32.8%), 25-OH-VD deficiency (<20 ng/ml) in n = 398 (51.0%), n = 246 (31.5%) participants were smokers. Presence of current relapse [coefficient (c) = 1.48, p = 0.016], more severe fatigue (c = 0.26, p < 0.0001), lower 25-OH-VD (c = -0.03, p = 0.034) and smoking (c = 0.35, p = 0.008) were associated with higher BDI-II scores. Sex, age, disease course, EDSS, month of visit, EBNA1-IgG levels and brain volumes at baseline were not.CONCLUSION: Depressive symptoms need to be assessed in early MS. Patients during relapse seem especially vulnerable to depressive symptoms. Contributing factors such as fatigue, vitamin D deficiency and smoking, could specifically be targeted in future interventions and should be investigated in prospective studies.",
author = "Anke Salmen and Robert Hoepner and Vinzenz Fleischer and Milena Heldt and Barbara Gisevius and Jeremias Motte and Klemens Ruprecht and Ruth Schneider and Fisse, {Anna Lena} and Thomas Gr{\"u}ter and Carsten Lukas and Achim Berthele and Katrin Giglhuber and Martina Flaskamp and Mark M{\"u}hlau and Jan Kirschke and Stefan Bittner and Sergiu Groppa and Felix L{\"u}ssi and Antonios Bayas and Sven Meuth and Cristoph Heesen and Corinna Trebst and Brigitte Wildemann and {Then Bergh}, Florian and Gisela Antony and Tania K{\"u}mpfel and Friedemann Paul and Sandra Nischwitz and Hayrettin Tumani and Uwe Zettl and Bernhard Hemmer and Heinz Wiendl and Frauke Zipp and Ralf Gold",
note = "{\textcopyright} The Author(s), 2023.",
year = "2023",
doi = "10.1177/17562864231197309",
language = "English",
volume = "16",
pages = "17562864231197309",
journal = "THER ADV NEUROL DISO",
issn = "1756-2856",
publisher = "SAGE Publications",

}

RIS

TY - JOUR

T1 - Factors associated with depressive mood at the onset of multiple sclerosis - an analysis of 781 patients of the German NationMS cohort

AU - Salmen, Anke

AU - Hoepner, Robert

AU - Fleischer, Vinzenz

AU - Heldt, Milena

AU - Gisevius, Barbara

AU - Motte, Jeremias

AU - Ruprecht, Klemens

AU - Schneider, Ruth

AU - Fisse, Anna Lena

AU - Grüter, Thomas

AU - Lukas, Carsten

AU - Berthele, Achim

AU - Giglhuber, Katrin

AU - Flaskamp, Martina

AU - Mühlau, Mark

AU - Kirschke, Jan

AU - Bittner, Stefan

AU - Groppa, Sergiu

AU - Lüssi, Felix

AU - Bayas, Antonios

AU - Meuth, Sven

AU - Heesen, Cristoph

AU - Trebst, Corinna

AU - Wildemann, Brigitte

AU - Then Bergh, Florian

AU - Antony, Gisela

AU - Kümpfel, Tania

AU - Paul, Friedemann

AU - Nischwitz, Sandra

AU - Tumani, Hayrettin

AU - Zettl, Uwe

AU - Hemmer, Bernhard

AU - Wiendl, Heinz

AU - Zipp, Frauke

AU - Gold, Ralf

N1 - © The Author(s), 2023.

PY - 2023

Y1 - 2023

N2 - BACKGROUND: Depression has a major impact on the disease burden of multiple sclerosis (MS). Analyses of overlapping MS and depression risk factors [smoking, vitamin D (25-OH-VD) and Epstein-Barr virus (EBV) infection] and sex, age, disease characteristics and neuroimaging features associated with depressive symptoms in early MS are scarce.OBJECTIVES: To assess an association of MS risk factors with depressive symptoms within the German NationMS cohort.DESIGN: Cross-sectional analysis within a multicenter observational study.METHODS: Baseline data of n = 781 adults with newly diagnosed clinically isolated syndrome or relapsing-remitting MS qualified for analysis. Global and region-specific magnetic resonance imaging (MRI)-volumetry parameters were available for n = 327 patients. Association of demographic factors, MS characteristics and risk factors [sex, age, smoking, disease course, presence of current relapse, expanded disability status scale (EDSS) score, fatigue (fatigue scale motor cognition), 25-OH-VD serum concentration, EBV nuclear antigen-1 IgG (EBNA1-IgG) serum levels] and depressive symptoms (Beck Depression Inventory-II, BDI-II) was tested as a primary outcome by multivariable linear regression. Non-parametric correlation and group comparison were performed for associations of MRI parameters and depressive symptoms.RESULTS: Mean age was 34.3 years (95% confidence interval: 33.6-35.0). The female-to-male ratio was 2.3:1. At least minimal depressive symptoms (BDI-II > 8) were present in n = 256 (32.8%), 25-OH-VD deficiency (<20 ng/ml) in n = 398 (51.0%), n = 246 (31.5%) participants were smokers. Presence of current relapse [coefficient (c) = 1.48, p = 0.016], more severe fatigue (c = 0.26, p < 0.0001), lower 25-OH-VD (c = -0.03, p = 0.034) and smoking (c = 0.35, p = 0.008) were associated with higher BDI-II scores. Sex, age, disease course, EDSS, month of visit, EBNA1-IgG levels and brain volumes at baseline were not.CONCLUSION: Depressive symptoms need to be assessed in early MS. Patients during relapse seem especially vulnerable to depressive symptoms. Contributing factors such as fatigue, vitamin D deficiency and smoking, could specifically be targeted in future interventions and should be investigated in prospective studies.

AB - BACKGROUND: Depression has a major impact on the disease burden of multiple sclerosis (MS). Analyses of overlapping MS and depression risk factors [smoking, vitamin D (25-OH-VD) and Epstein-Barr virus (EBV) infection] and sex, age, disease characteristics and neuroimaging features associated with depressive symptoms in early MS are scarce.OBJECTIVES: To assess an association of MS risk factors with depressive symptoms within the German NationMS cohort.DESIGN: Cross-sectional analysis within a multicenter observational study.METHODS: Baseline data of n = 781 adults with newly diagnosed clinically isolated syndrome or relapsing-remitting MS qualified for analysis. Global and region-specific magnetic resonance imaging (MRI)-volumetry parameters were available for n = 327 patients. Association of demographic factors, MS characteristics and risk factors [sex, age, smoking, disease course, presence of current relapse, expanded disability status scale (EDSS) score, fatigue (fatigue scale motor cognition), 25-OH-VD serum concentration, EBV nuclear antigen-1 IgG (EBNA1-IgG) serum levels] and depressive symptoms (Beck Depression Inventory-II, BDI-II) was tested as a primary outcome by multivariable linear regression. Non-parametric correlation and group comparison were performed for associations of MRI parameters and depressive symptoms.RESULTS: Mean age was 34.3 years (95% confidence interval: 33.6-35.0). The female-to-male ratio was 2.3:1. At least minimal depressive symptoms (BDI-II > 8) were present in n = 256 (32.8%), 25-OH-VD deficiency (<20 ng/ml) in n = 398 (51.0%), n = 246 (31.5%) participants were smokers. Presence of current relapse [coefficient (c) = 1.48, p = 0.016], more severe fatigue (c = 0.26, p < 0.0001), lower 25-OH-VD (c = -0.03, p = 0.034) and smoking (c = 0.35, p = 0.008) were associated with higher BDI-II scores. Sex, age, disease course, EDSS, month of visit, EBNA1-IgG levels and brain volumes at baseline were not.CONCLUSION: Depressive symptoms need to be assessed in early MS. Patients during relapse seem especially vulnerable to depressive symptoms. Contributing factors such as fatigue, vitamin D deficiency and smoking, could specifically be targeted in future interventions and should be investigated in prospective studies.

U2 - 10.1177/17562864231197309

DO - 10.1177/17562864231197309

M3 - SCORING: Journal article

C2 - 37692259

VL - 16

SP - 17562864231197309

JO - THER ADV NEUROL DISO

JF - THER ADV NEUROL DISO

SN - 1756-2856

ER -