Expression of Tas1 taste receptors in mammalian spermatozoa: functional role of Tas1r1 in regulating basal Ca²⁺ and cAMP concentrations in spermatozoa.
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Expression of Tas1 taste receptors in mammalian spermatozoa: functional role of Tas1r1 in regulating basal Ca²⁺ and cAMP concentrations in spermatozoa. / Meyer, Dorke; Voigt, Anja; Widmayer, Patricia; Borth, Heike; Huebner, Sandra; Breit, Andreas; Marschall, Susan; Angelis, de; Boehm, Ulrich; Boehm, Ulrich; Meyerhof, Wolfgang; Gudermann, Thomas; Boekhoff, Ingrid.
in: PLOS ONE, Jahrgang 7, Nr. 2, 2, 2012, S. 32354.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Expression of Tas1 taste receptors in mammalian spermatozoa: functional role of Tas1r1 in regulating basal Ca²⁺ and cAMP concentrations in spermatozoa.
AU - Meyer, Dorke
AU - Voigt, Anja
AU - Widmayer, Patricia
AU - Borth, Heike
AU - Huebner, Sandra
AU - Breit, Andreas
AU - Marschall, Susan
AU - Angelis, de
AU - Boehm, Ulrich
AU - Boehm, Ulrich
AU - Meyerhof, Wolfgang
AU - Gudermann, Thomas
AU - Boekhoff, Ingrid
PY - 2012
Y1 - 2012
N2 - During their transit through the female genital tract, sperm have to recognize and discriminate numerous chemical compounds. However, our current knowledge of the molecular identity of appropriate chemosensory receptor proteins in sperm is still rudimentary. Considering that members of the Tas1r family of taste receptors are able to discriminate between a broad diversity of hydrophilic chemosensory substances, the expression of taste receptors in mammalian spermatozoa was examined.
AB - During their transit through the female genital tract, sperm have to recognize and discriminate numerous chemical compounds. However, our current knowledge of the molecular identity of appropriate chemosensory receptor proteins in sperm is still rudimentary. Considering that members of the Tas1r family of taste receptors are able to discriminate between a broad diversity of hydrophilic chemosensory substances, the expression of taste receptors in mammalian spermatozoa was examined.
KW - Animals
KW - Humans
KW - Male
KW - Female
KW - Mice
KW - Mice, Inbred BALB C
KW - Mice, Inbred C57BL
KW - Mice, Knockout
KW - Models, Biological
KW - Rats
KW - Reverse Transcriptase Polymerase Chain Reaction
KW - Gene Expression
KW - Mice, Transgenic
KW - Rats, Wistar
KW - Blotting, Western
KW - Microscopy, Confocal
KW - Cyclic AMP/metabolism
KW - Calcium/metabolism
KW - RNA, Messenger/genetics/metabolism
KW - Mice, 129 Strain
KW - Luminescent Proteins/genetics/metabolism
KW - Receptors, G-Protein-Coupled/genetics/metabolism/physiology
KW - Sperm Head/metabolism
KW - Spermatozoa/metabolism
KW - Testis/cytology/metabolism
KW - Animals
KW - Humans
KW - Male
KW - Female
KW - Mice
KW - Mice, Inbred BALB C
KW - Mice, Inbred C57BL
KW - Mice, Knockout
KW - Models, Biological
KW - Rats
KW - Reverse Transcriptase Polymerase Chain Reaction
KW - Gene Expression
KW - Mice, Transgenic
KW - Rats, Wistar
KW - Blotting, Western
KW - Microscopy, Confocal
KW - Cyclic AMP/metabolism
KW - Calcium/metabolism
KW - RNA, Messenger/genetics/metabolism
KW - Mice, 129 Strain
KW - Luminescent Proteins/genetics/metabolism
KW - Receptors, G-Protein-Coupled/genetics/metabolism/physiology
KW - Sperm Head/metabolism
KW - Spermatozoa/metabolism
KW - Testis/cytology/metabolism
U2 - 10.1371/journal.pone.0032354
DO - 10.1371/journal.pone.0032354
M3 - SCORING: Journal article
VL - 7
SP - 32354
JO - PLOS ONE
JF - PLOS ONE
SN - 1932-6203
IS - 2
M1 - 2
ER -