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Expression of SNURF-SNRPN upstream transcripts and epigenetic regulatory genes during human spermatogenesis.

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Expression of SNURF-SNRPN upstream transcripts and epigenetic regulatory genes during human spermatogenesis. / Wawrzik, Michaela; Spiess, Andrej-Nikolai; Herrmann, Ralf; Buiting, Karin; Horsthemke, Bernhard.

in: EUR J HUM GENET, 2009.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Wawrzik, M, Spiess, A-N, Herrmann, R, Buiting, K & Horsthemke, B 2009, 'Expression of SNURF-SNRPN upstream transcripts and epigenetic regulatory genes during human spermatogenesis.', EUR J HUM GENET. <http://www.ncbi.nlm.nih.gov/pubmed/19471314?dopt=Citation>

APA

Wawrzik, M., Spiess, A-N., Herrmann, R., Buiting, K., & Horsthemke, B. (2009). Expression of SNURF-SNRPN upstream transcripts and epigenetic regulatory genes during human spermatogenesis. EUR J HUM GENET. http://www.ncbi.nlm.nih.gov/pubmed/19471314?dopt=Citation

Vancouver

Wawrzik M, Spiess A-N, Herrmann R, Buiting K, Horsthemke B. Expression of SNURF-SNRPN upstream transcripts and epigenetic regulatory genes during human spermatogenesis. EUR J HUM GENET. 2009.

Bibtex

@article{aedc579375194f96ac3b69f5b36da11a,
title = "Expression of SNURF-SNRPN upstream transcripts and epigenetic regulatory genes during human spermatogenesis.",
abstract = "The imprinted domain in human 15q11-q13 is controlled by a bipartite imprinting centre (IC), which overlaps the 5' part of the paternally expressed SNURF-SNRPN gene. We have recently described two novel genes upstream of SNURF-SNRPN (PWRN1 and PWRN2), which are biallelically expressed in the testis. We have now found that PWRN1 represents an alternative 5' part of SNURF-SNRPN, and that its expression in the brain is imprinted. To determine when the locus is activated during spermatogenesis and which factors are involved in this process, we have mined gene-expression data of testicular biopsies from men with different types of spermatogenic failure. Whereas PWRN1-SNURF-SNRPN and PWRN2 are expressed in post-meiotic germ cells only, a hitherto undetected SNURF-SNRPN upstream transcript is expressed already at meiosis. Several epigenetic factors (eg, MBD1 and MBD2 isoforms, MBD3L1, SUVH39H2, BRDT, and EZH2) are upregulated at specific stages of spermatogenesis, suggesting that they play an important role in the epigenetic reprogramming during spermatogenesis.European Journal of Human Genetics advance online publication, 27 May 2009; doi:10.1038/ejhg.2009.83.",
author = "Michaela Wawrzik and Andrej-Nikolai Spiess and Ralf Herrmann and Karin Buiting and Bernhard Horsthemke",
year = "2009",
language = "Deutsch",
journal = "EUR J HUM GENET",
issn = "1018-4813",
publisher = "NATURE PUBLISHING GROUP",

}

RIS

TY - JOUR

T1 - Expression of SNURF-SNRPN upstream transcripts and epigenetic regulatory genes during human spermatogenesis.

AU - Wawrzik, Michaela

AU - Spiess, Andrej-Nikolai

AU - Herrmann, Ralf

AU - Buiting, Karin

AU - Horsthemke, Bernhard

PY - 2009

Y1 - 2009

N2 - The imprinted domain in human 15q11-q13 is controlled by a bipartite imprinting centre (IC), which overlaps the 5' part of the paternally expressed SNURF-SNRPN gene. We have recently described two novel genes upstream of SNURF-SNRPN (PWRN1 and PWRN2), which are biallelically expressed in the testis. We have now found that PWRN1 represents an alternative 5' part of SNURF-SNRPN, and that its expression in the brain is imprinted. To determine when the locus is activated during spermatogenesis and which factors are involved in this process, we have mined gene-expression data of testicular biopsies from men with different types of spermatogenic failure. Whereas PWRN1-SNURF-SNRPN and PWRN2 are expressed in post-meiotic germ cells only, a hitherto undetected SNURF-SNRPN upstream transcript is expressed already at meiosis. Several epigenetic factors (eg, MBD1 and MBD2 isoforms, MBD3L1, SUVH39H2, BRDT, and EZH2) are upregulated at specific stages of spermatogenesis, suggesting that they play an important role in the epigenetic reprogramming during spermatogenesis.European Journal of Human Genetics advance online publication, 27 May 2009; doi:10.1038/ejhg.2009.83.

AB - The imprinted domain in human 15q11-q13 is controlled by a bipartite imprinting centre (IC), which overlaps the 5' part of the paternally expressed SNURF-SNRPN gene. We have recently described two novel genes upstream of SNURF-SNRPN (PWRN1 and PWRN2), which are biallelically expressed in the testis. We have now found that PWRN1 represents an alternative 5' part of SNURF-SNRPN, and that its expression in the brain is imprinted. To determine when the locus is activated during spermatogenesis and which factors are involved in this process, we have mined gene-expression data of testicular biopsies from men with different types of spermatogenic failure. Whereas PWRN1-SNURF-SNRPN and PWRN2 are expressed in post-meiotic germ cells only, a hitherto undetected SNURF-SNRPN upstream transcript is expressed already at meiosis. Several epigenetic factors (eg, MBD1 and MBD2 isoforms, MBD3L1, SUVH39H2, BRDT, and EZH2) are upregulated at specific stages of spermatogenesis, suggesting that they play an important role in the epigenetic reprogramming during spermatogenesis.European Journal of Human Genetics advance online publication, 27 May 2009; doi:10.1038/ejhg.2009.83.

M3 - SCORING: Zeitschriftenaufsatz

JO - EUR J HUM GENET

JF - EUR J HUM GENET

SN - 1018-4813

ER -