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Expression of functional GABAA receptors in isolated human insulinoma cells.

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Expression of functional GABAA receptors in isolated human insulinoma cells. / Glassmeier, Günter; Höpfner, M; Buhr, H; Lemmer, K; Riecken, E O; Stein, H; Quabbe, H J; Rancso, C; Wiedenmann, B; Scherübl, H.

in: ANN NY ACAD SCI, Jahrgang 859, 1998, S. 241-248.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Glassmeier, G, Höpfner, M, Buhr, H, Lemmer, K, Riecken, EO, Stein, H, Quabbe, HJ, Rancso, C, Wiedenmann, B & Scherübl, H 1998, 'Expression of functional GABAA receptors in isolated human insulinoma cells.', ANN NY ACAD SCI, Jg. 859, S. 241-248. <http://www.ncbi.nlm.nih.gov/pubmed/9928397?dopt=Citation>

APA

Glassmeier, G., Höpfner, M., Buhr, H., Lemmer, K., Riecken, E. O., Stein, H., Quabbe, H. J., Rancso, C., Wiedenmann, B., & Scherübl, H. (1998). Expression of functional GABAA receptors in isolated human insulinoma cells. ANN NY ACAD SCI, 859, 241-248. http://www.ncbi.nlm.nih.gov/pubmed/9928397?dopt=Citation

Vancouver

Glassmeier G, Höpfner M, Buhr H, Lemmer K, Riecken EO, Stein H et al. Expression of functional GABAA receptors in isolated human insulinoma cells. ANN NY ACAD SCI. 1998;859:241-248.

Bibtex

@article{743f0006111d4f9e8787554a03a87e9e,
title = "Expression of functional GABAA receptors in isolated human insulinoma cells.",
abstract = "Pancreatic islets contain and release high concentrations of GABA. GABA is thought to play a paracrine role in beta-cells. Searching for a paracrine function of GABA in neoplastic beta-cells we performed patch-clamp studies in isolated human insulinoma cells. We show that human insulinoma cells can express functional GABAA receptors. Activation of GABAA receptors caused a reversible membrane depolarization in a subgroup of insulinoma cells. Membrane depolarization resulted in transmembraneous calcium influx through voltage-gated calcium channels and stimulation of insulin secretion. Insulin secretion was increased by the GABAA receptor agonist muscimol (50 microM) by about 280%. Thus, GABAA receptors can be expressed in human insulinoma cells and can regulate their insulin release.",
author = "G{\"u}nter Glassmeier and M H{\"o}pfner and H Buhr and K Lemmer and Riecken, {E O} and H Stein and Quabbe, {H J} and C Rancso and B Wiedenmann and H Scher{\"u}bl",
year = "1998",
language = "Deutsch",
volume = "859",
pages = "241--248",
journal = "ANN NY ACAD SCI",
issn = "0077-8923",
publisher = "Wiley-Blackwell",

}

RIS

TY - JOUR

T1 - Expression of functional GABAA receptors in isolated human insulinoma cells.

AU - Glassmeier, Günter

AU - Höpfner, M

AU - Buhr, H

AU - Lemmer, K

AU - Riecken, E O

AU - Stein, H

AU - Quabbe, H J

AU - Rancso, C

AU - Wiedenmann, B

AU - Scherübl, H

PY - 1998

Y1 - 1998

N2 - Pancreatic islets contain and release high concentrations of GABA. GABA is thought to play a paracrine role in beta-cells. Searching for a paracrine function of GABA in neoplastic beta-cells we performed patch-clamp studies in isolated human insulinoma cells. We show that human insulinoma cells can express functional GABAA receptors. Activation of GABAA receptors caused a reversible membrane depolarization in a subgroup of insulinoma cells. Membrane depolarization resulted in transmembraneous calcium influx through voltage-gated calcium channels and stimulation of insulin secretion. Insulin secretion was increased by the GABAA receptor agonist muscimol (50 microM) by about 280%. Thus, GABAA receptors can be expressed in human insulinoma cells and can regulate their insulin release.

AB - Pancreatic islets contain and release high concentrations of GABA. GABA is thought to play a paracrine role in beta-cells. Searching for a paracrine function of GABA in neoplastic beta-cells we performed patch-clamp studies in isolated human insulinoma cells. We show that human insulinoma cells can express functional GABAA receptors. Activation of GABAA receptors caused a reversible membrane depolarization in a subgroup of insulinoma cells. Membrane depolarization resulted in transmembraneous calcium influx through voltage-gated calcium channels and stimulation of insulin secretion. Insulin secretion was increased by the GABAA receptor agonist muscimol (50 microM) by about 280%. Thus, GABAA receptors can be expressed in human insulinoma cells and can regulate their insulin release.

M3 - SCORING: Zeitschriftenaufsatz

VL - 859

SP - 241

EP - 248

JO - ANN NY ACAD SCI

JF - ANN NY ACAD SCI

SN - 0077-8923

ER -