Expression of Epithelial Mesenchymal Transition and Cancer Stem Cell Markers in Circulating Tumor Cells

Stefan Werner; Arnulf Stenzl; Klaus Pantel; Tilman Todenhöfer

doi:10.1007/978-3-319-55947-6_11

Expression of Epithelial Mesenchymal Transition and Cancer Stem Cell Markers in Circulating Tumor Cells

Standard

Expression of Epithelial Mesenchymal Transition and Cancer Stem Cell Markers in Circulating Tumor Cells. / Werner, Stefan; Stenzl, Arnulf; Pantel, Klaus; Todenhöfer, Tilman.

in: ADV EXP MED BIOL, Jahrgang 994, 2017, S. 205-228.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Werner, S, Stenzl, A, Pantel, K & Todenhöfer, T 2017, 'Expression of Epithelial Mesenchymal Transition and Cancer Stem Cell Markers in Circulating Tumor Cells', ADV EXP MED BIOL, Jg. 994, S. 205-228. https://doi.org/10.1007/978-3-319-55947-6_11

APA

Werner, S., Stenzl, A., Pantel, K., & Todenhöfer, T. (2017). Expression of Epithelial Mesenchymal Transition and Cancer Stem Cell Markers in Circulating Tumor Cells. ADV EXP MED BIOL, 994, 205-228. https://doi.org/10.1007/978-3-319-55947-6_11

Vancouver

Werner S, Stenzl A, Pantel K, Todenhöfer T. Expression of Epithelial Mesenchymal Transition and Cancer Stem Cell Markers in Circulating Tumor Cells. ADV EXP MED BIOL. 2017;994:205-228. https://doi.org/10.1007/978-3-319-55947-6_11

Bibtex

@article{79a504c4ebe74105bdf0d2783de2f7c3,

title = "Expression of Epithelial Mesenchymal Transition and Cancer Stem Cell Markers in Circulating Tumor Cells",

abstract = "The characterization of circulating tumor cells (CTC) has the potential not only to provide important insights into molecular alterations of advanced tumor disease but also to facilitate risk prediction. Epithelial mesenchymal transition (EMT) has been discovered as important process for the development of metastases and the dissemination of tumor cells into the blood stream. In different tumor types, CTC with a mesenchymal phenotype have been reported that have presumably underwent EMT. Moreover, CTC with stem-cell like characteristics have been postulated as important drivers of tumor progression. Different platforms have been introduced to allow CTC enrichment independent of expression of epithelial antigens, as these may be downregulated in EMT- or stem-cell-like CTC. Both for CTCs with EMT- or stem-cell features different markers have been proposed. However, there is still a lack of evidence on the association of these markers with functional features and characteristics for stem cells and cells undergoing EMT.",

keywords = "Journal Article",

author = "Stefan Werner and Arnulf Stenzl and Klaus Pantel and Tilman Todenh{\"o}fer",

year = "2017",

doi = "10.1007/978-3-319-55947-6_11",

language = "English",

volume = "994",

pages = "205--228",

journal = "ADV EXP MED BIOL",

issn = "0065-2598",

publisher = "Springer New York",

}

RIS

TY - JOUR

T1 - Expression of Epithelial Mesenchymal Transition and Cancer Stem Cell Markers in Circulating Tumor Cells

AU - Werner, Stefan

AU - Stenzl, Arnulf

AU - Pantel, Klaus

AU - Todenhöfer, Tilman

PY - 2017

Y1 - 2017

N2 - The characterization of circulating tumor cells (CTC) has the potential not only to provide important insights into molecular alterations of advanced tumor disease but also to facilitate risk prediction. Epithelial mesenchymal transition (EMT) has been discovered as important process for the development of metastases and the dissemination of tumor cells into the blood stream. In different tumor types, CTC with a mesenchymal phenotype have been reported that have presumably underwent EMT. Moreover, CTC with stem-cell like characteristics have been postulated as important drivers of tumor progression. Different platforms have been introduced to allow CTC enrichment independent of expression of epithelial antigens, as these may be downregulated in EMT- or stem-cell-like CTC. Both for CTCs with EMT- or stem-cell features different markers have been proposed. However, there is still a lack of evidence on the association of these markers with functional features and characteristics for stem cells and cells undergoing EMT.

AB - The characterization of circulating tumor cells (CTC) has the potential not only to provide important insights into molecular alterations of advanced tumor disease but also to facilitate risk prediction. Epithelial mesenchymal transition (EMT) has been discovered as important process for the development of metastases and the dissemination of tumor cells into the blood stream. In different tumor types, CTC with a mesenchymal phenotype have been reported that have presumably underwent EMT. Moreover, CTC with stem-cell like characteristics have been postulated as important drivers of tumor progression. Different platforms have been introduced to allow CTC enrichment independent of expression of epithelial antigens, as these may be downregulated in EMT- or stem-cell-like CTC. Both for CTCs with EMT- or stem-cell features different markers have been proposed. However, there is still a lack of evidence on the association of these markers with functional features and characteristics for stem cells and cells undergoing EMT.

KW - Journal Article

U2 - 10.1007/978-3-319-55947-6_11

DO - 10.1007/978-3-319-55947-6_11

M3 - SCORING: Journal article

C2 - 28560676

VL - 994

SP - 205

EP - 228

JO - ADV EXP MED BIOL

JF - ADV EXP MED BIOL

SN - 0065-2598

ER -