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Expression of EpCam and villin in Barrett's esophagus and in gastric cardia.

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Expression of EpCam and villin in Barrett's esophagus and in gastric cardia. / Anders, Mario; Sarbia, Mario; Grotzinger, Carsten; Meining, Alexander; Hofler, Heinz; Wiedenmann, Bertram; Rösch, Thomas.

in: DIS MARKERS, Jahrgang 24, Nr. 6, 6, 2008, S. 287-292.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Anders, M, Sarbia, M, Grotzinger, C, Meining, A, Hofler, H, Wiedenmann, B & Rösch, T 2008, 'Expression of EpCam and villin in Barrett's esophagus and in gastric cardia.', DIS MARKERS, Jg. 24, Nr. 6, 6, S. 287-292. https://doi.org/10.1155/2008/679893

APA

Anders, M., Sarbia, M., Grotzinger, C., Meining, A., Hofler, H., Wiedenmann, B., & Rösch, T. (2008). Expression of EpCam and villin in Barrett's esophagus and in gastric cardia. DIS MARKERS, 24(6), 287-292. [6]. https://doi.org/10.1155/2008/679893

Vancouver

Anders M, Sarbia M, Grotzinger C, Meining A, Hofler H, Wiedenmann B et al. Expression of EpCam and villin in Barrett's esophagus and in gastric cardia. DIS MARKERS. 2008;24(6):287-292. 6. https://doi.org/10.1155/2008/679893

Bibtex

@article{970f29860bf5443189bdfedc5b194517,
title = "Expression of EpCam and villin in Barrett's esophagus and in gastric cardia.",
abstract = "In the current study we aimed to clarify the potential of EpCAM and villin as in vivo biomarkers for both Barrett esophagus (BE)-associated neoplasia and BE versus cardiac mucosa. Immunohistochemical staining in BE with various degrees of intraepithelial neoplasia (IN), Barrett carcinoma (BC) and in normal cardiac mucosa (CM) revealed a lack of EpCam and villin in squamous esophageal epithelium. All specimens of IN and BC showed EpCam with varying staining intensities. In 57% of CM samples a weak signal was detected; the remainder displayed strong EpCam expression. Villin was found in 97% of BE specimens and in all those with IN; 37% of BC and 75% of CM specimens were~also positive. We conclude that expression of EpCam and villin differs only between squamous epithelium and BE. Determination of these proteins does not allow discrimination between different degrees of neoplasia or between esophageal intestinal metaplasia and cardiac mucosa.",
author = "Mario Anders and Mario Sarbia and Carsten Grotzinger and Alexander Meining and Heinz Hofler and Bertram Wiedenmann and Thomas R{\"o}sch",
year = "2008",
doi = "10.1155/2008/679893",
language = "Deutsch",
volume = "24",
pages = "287--292",
journal = "DIS MARKERS",
issn = "0278-0240",
publisher = "IOS Press",
number = "6",

}

RIS

TY - JOUR

T1 - Expression of EpCam and villin in Barrett's esophagus and in gastric cardia.

AU - Anders, Mario

AU - Sarbia, Mario

AU - Grotzinger, Carsten

AU - Meining, Alexander

AU - Hofler, Heinz

AU - Wiedenmann, Bertram

AU - Rösch, Thomas

PY - 2008

Y1 - 2008

N2 - In the current study we aimed to clarify the potential of EpCAM and villin as in vivo biomarkers for both Barrett esophagus (BE)-associated neoplasia and BE versus cardiac mucosa. Immunohistochemical staining in BE with various degrees of intraepithelial neoplasia (IN), Barrett carcinoma (BC) and in normal cardiac mucosa (CM) revealed a lack of EpCam and villin in squamous esophageal epithelium. All specimens of IN and BC showed EpCam with varying staining intensities. In 57% of CM samples a weak signal was detected; the remainder displayed strong EpCam expression. Villin was found in 97% of BE specimens and in all those with IN; 37% of BC and 75% of CM specimens were~also positive. We conclude that expression of EpCam and villin differs only between squamous epithelium and BE. Determination of these proteins does not allow discrimination between different degrees of neoplasia or between esophageal intestinal metaplasia and cardiac mucosa.

AB - In the current study we aimed to clarify the potential of EpCAM and villin as in vivo biomarkers for both Barrett esophagus (BE)-associated neoplasia and BE versus cardiac mucosa. Immunohistochemical staining in BE with various degrees of intraepithelial neoplasia (IN), Barrett carcinoma (BC) and in normal cardiac mucosa (CM) revealed a lack of EpCam and villin in squamous esophageal epithelium. All specimens of IN and BC showed EpCam with varying staining intensities. In 57% of CM samples a weak signal was detected; the remainder displayed strong EpCam expression. Villin was found in 97% of BE specimens and in all those with IN; 37% of BC and 75% of CM specimens were~also positive. We conclude that expression of EpCam and villin differs only between squamous epithelium and BE. Determination of these proteins does not allow discrimination between different degrees of neoplasia or between esophageal intestinal metaplasia and cardiac mucosa.

U2 - 10.1155/2008/679893

DO - 10.1155/2008/679893

M3 - SCORING: Zeitschriftenaufsatz

VL - 24

SP - 287

EP - 292

JO - DIS MARKERS

JF - DIS MARKERS

SN - 0278-0240

IS - 6

M1 - 6

ER -