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Expression of complement regulator proteins in primary and metastatic malignant melanoma

Standard

Expression of complement regulator proteins in primary and metastatic malignant melanoma. / Weichenthal, M; Siemann, U; Neuber, K; Breitbart, E W.

in: J CUTAN PATHOL, Jahrgang 26, Nr. 5, 05.1999, S. 217-21.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Weichenthal, M, Siemann, U, Neuber, K & Breitbart, EW 1999, 'Expression of complement regulator proteins in primary and metastatic malignant melanoma', J CUTAN PATHOL, Jg. 26, Nr. 5, S. 217-21. https://doi.org/10.1111/j.1600-0560.1999.tb01833.x

APA

Weichenthal, M., Siemann, U., Neuber, K., & Breitbart, E. W. (1999). Expression of complement regulator proteins in primary and metastatic malignant melanoma. J CUTAN PATHOL, 26(5), 217-21. https://doi.org/10.1111/j.1600-0560.1999.tb01833.x

Vancouver

Weichenthal M, Siemann U, Neuber K, Breitbart EW. Expression of complement regulator proteins in primary and metastatic malignant melanoma. J CUTAN PATHOL. 1999 Mai;26(5):217-21. https://doi.org/10.1111/j.1600-0560.1999.tb01833.x

Bibtex

@article{3e080aa621cb4523a340cd817855a02e,
title = "Expression of complement regulator proteins in primary and metastatic malignant melanoma",
abstract = "The expression of complement regulatory antigens C3b/C4b receptor, (CD35) membrane cofactor protein (CD46), decay accelerating factor (CD55), and homologous restriction factor 20 (CD59) was determined immunohistochemically on ten primary malignant melanomas, 16 metastatic lesions, and ten melanocytic nevi. All of the melanocytic nevi and 9/10 primary melanomas showed both expression of CD46 and CD59. In one primary melanoma lacking CD46, expression of CD35 could be detected. In metastatic melanoma, 9/16 metastases were CD46+/CD59+, two were CD46-/CD59+, one CD46+/CD59-, and four CD46-/CD59-. Additionally, CD55 could be detected in two CD46+/CD59+ metastases, and CD35 in one. Expression or lack of complement regulatory antigens did not correlate with the expression of GD2, GD3, HMB-45 or S-100. In conclusion, some cases of metastatic melanoma show loss of normal expression of complement regulatory proteins. This might have implications on the immune response or the efficacy of immune therapy in malignant melanoma.",
keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Antigens, CD/biosynthesis, Antigens, Neoplasm/metabolism, Child, Female, Gangliosides/metabolism, Humans, Immunohistochemistry, Male, Melanoma/metabolism, Melanoma-Specific Antigens, Middle Aged, Neoplasm Proteins/metabolism, Nevus, Pigmented/metabolism, S100 Proteins/metabolism, Skin Neoplasms/metabolism",
author = "M Weichenthal and U Siemann and K Neuber and Breitbart, {E W}",
year = "1999",
month = may,
doi = "10.1111/j.1600-0560.1999.tb01833.x",
language = "English",
volume = "26",
pages = "217--21",
journal = "J CUTAN PATHOL",
issn = "0303-6987",
publisher = "Wiley-Blackwell",
number = "5",

}

RIS

TY - JOUR

T1 - Expression of complement regulator proteins in primary and metastatic malignant melanoma

AU - Weichenthal, M

AU - Siemann, U

AU - Neuber, K

AU - Breitbart, E W

PY - 1999/5

Y1 - 1999/5

N2 - The expression of complement regulatory antigens C3b/C4b receptor, (CD35) membrane cofactor protein (CD46), decay accelerating factor (CD55), and homologous restriction factor 20 (CD59) was determined immunohistochemically on ten primary malignant melanomas, 16 metastatic lesions, and ten melanocytic nevi. All of the melanocytic nevi and 9/10 primary melanomas showed both expression of CD46 and CD59. In one primary melanoma lacking CD46, expression of CD35 could be detected. In metastatic melanoma, 9/16 metastases were CD46+/CD59+, two were CD46-/CD59+, one CD46+/CD59-, and four CD46-/CD59-. Additionally, CD55 could be detected in two CD46+/CD59+ metastases, and CD35 in one. Expression or lack of complement regulatory antigens did not correlate with the expression of GD2, GD3, HMB-45 or S-100. In conclusion, some cases of metastatic melanoma show loss of normal expression of complement regulatory proteins. This might have implications on the immune response or the efficacy of immune therapy in malignant melanoma.

AB - The expression of complement regulatory antigens C3b/C4b receptor, (CD35) membrane cofactor protein (CD46), decay accelerating factor (CD55), and homologous restriction factor 20 (CD59) was determined immunohistochemically on ten primary malignant melanomas, 16 metastatic lesions, and ten melanocytic nevi. All of the melanocytic nevi and 9/10 primary melanomas showed both expression of CD46 and CD59. In one primary melanoma lacking CD46, expression of CD35 could be detected. In metastatic melanoma, 9/16 metastases were CD46+/CD59+, two were CD46-/CD59+, one CD46+/CD59-, and four CD46-/CD59-. Additionally, CD55 could be detected in two CD46+/CD59+ metastases, and CD35 in one. Expression or lack of complement regulatory antigens did not correlate with the expression of GD2, GD3, HMB-45 or S-100. In conclusion, some cases of metastatic melanoma show loss of normal expression of complement regulatory proteins. This might have implications on the immune response or the efficacy of immune therapy in malignant melanoma.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Antigens, CD/biosynthesis

KW - Antigens, Neoplasm/metabolism

KW - Child

KW - Female

KW - Gangliosides/metabolism

KW - Humans

KW - Immunohistochemistry

KW - Male

KW - Melanoma/metabolism

KW - Melanoma-Specific Antigens

KW - Middle Aged

KW - Neoplasm Proteins/metabolism

KW - Nevus, Pigmented/metabolism

KW - S100 Proteins/metabolism

KW - Skin Neoplasms/metabolism

U2 - 10.1111/j.1600-0560.1999.tb01833.x

DO - 10.1111/j.1600-0560.1999.tb01833.x

M3 - SCORING: Journal article

C2 - 10408345

VL - 26

SP - 217

EP - 221

JO - J CUTAN PATHOL

JF - J CUTAN PATHOL

SN - 0303-6987

IS - 5

ER -