PortalPublikationenExpression and distribution of tenascin in rat submandibular...

Expression and distribution of tenascin in rat submandibular glands following irradiation

Standard

Expression and distribution of tenascin in rat submandibular glands following irradiation. / Bartel-Friedrich, S; Lautenschläger, C; Holzhausen, H-J; Friedrich, R E.

in: ANTICANCER RES, Jahrgang 30, Nr. 5, 01.05.2010, S. 1593-8.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Bartel-Friedrich, S, Lautenschläger, C, Holzhausen, H-J & Friedrich, RE 2010, 'Expression and distribution of tenascin in rat submandibular glands following irradiation', ANTICANCER RES, Jg. 30, Nr. 5, S. 1593-8.

APA

Bartel-Friedrich, S., Lautenschläger, C., Holzhausen, H-J., & Friedrich, R. E. (2010). Expression and distribution of tenascin in rat submandibular glands following irradiation. ANTICANCER RES, 30(5), 1593-8.

Vancouver

Bartel-Friedrich S, Lautenschläger C, Holzhausen H-J, Friedrich RE. Expression and distribution of tenascin in rat submandibular glands following irradiation. ANTICANCER RES. 2010 Mai 1;30(5):1593-8.

Bibtex

@article{1205d6c83c8b4e358c17aecbaebd47ea,
title = "Expression and distribution of tenascin in rat submandibular glands following irradiation",
abstract = "UNLABELLED: The aim of this study was to investigate the late changes in the expression of tenascin-C (TN-C) in salivary glands (SG) following irradiation (IRR).MATERIALS AND METHODS: In 124 submandibular SG from 62 Wistar rats, the effect of IRR dose (fractionated IRR, 2 Gy per day, total dose of 20, 40, or 60 Gy), time since IRR (6 months vs. 12 months), and animal age (1 year vs. 1.5 years) on TN-C expression profile and its distribution pattern was investigated.RESULTS: Expression of TN-C showed slight to moderate alterations in the irradiated specimens. The expression differed in frequency and degree among various tissue structures. The most striking finding was pronounced dose-dependent heterogeneity, with increases, decreases and fluctuations in staining.CONCLUSION: The staining of TN-C predominantly showed notable dose-dependent heterogeneity, persisting for up to 1 year after completion of IRR. Thus, these findings can be attributed to late radiation effects. The altered expression of tenascin-C may play at least a partial role in late radiogenic dysfunction of the submandibular SG.",
keywords = "Animals, Dose Fractionation, Dose-Response Relationship, Radiation, Gene Expression Regulation, Immune System, Multivariate Analysis, Rats, Rats, Wistar, Submandibular Gland, Tenascin, Time Factors",
author = "S Bartel-Friedrich and C Lautenschl{\"a}ger and H-J Holzhausen and Friedrich, {R E}",
year = "2010",
month = may,
day = "1",
language = "English",
volume = "30",
pages = "1593--8",
journal = "ANTICANCER RES",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "5",

}

RIS

TY - JOUR

T1 - Expression and distribution of tenascin in rat submandibular glands following irradiation

AU - Bartel-Friedrich, S

AU - Lautenschläger, C

AU - Holzhausen, H-J

AU - Friedrich, R E

PY - 2010/5/1

Y1 - 2010/5/1

N2 - UNLABELLED: The aim of this study was to investigate the late changes in the expression of tenascin-C (TN-C) in salivary glands (SG) following irradiation (IRR).MATERIALS AND METHODS: In 124 submandibular SG from 62 Wistar rats, the effect of IRR dose (fractionated IRR, 2 Gy per day, total dose of 20, 40, or 60 Gy), time since IRR (6 months vs. 12 months), and animal age (1 year vs. 1.5 years) on TN-C expression profile and its distribution pattern was investigated.RESULTS: Expression of TN-C showed slight to moderate alterations in the irradiated specimens. The expression differed in frequency and degree among various tissue structures. The most striking finding was pronounced dose-dependent heterogeneity, with increases, decreases and fluctuations in staining.CONCLUSION: The staining of TN-C predominantly showed notable dose-dependent heterogeneity, persisting for up to 1 year after completion of IRR. Thus, these findings can be attributed to late radiation effects. The altered expression of tenascin-C may play at least a partial role in late radiogenic dysfunction of the submandibular SG.

AB - UNLABELLED: The aim of this study was to investigate the late changes in the expression of tenascin-C (TN-C) in salivary glands (SG) following irradiation (IRR).MATERIALS AND METHODS: In 124 submandibular SG from 62 Wistar rats, the effect of IRR dose (fractionated IRR, 2 Gy per day, total dose of 20, 40, or 60 Gy), time since IRR (6 months vs. 12 months), and animal age (1 year vs. 1.5 years) on TN-C expression profile and its distribution pattern was investigated.RESULTS: Expression of TN-C showed slight to moderate alterations in the irradiated specimens. The expression differed in frequency and degree among various tissue structures. The most striking finding was pronounced dose-dependent heterogeneity, with increases, decreases and fluctuations in staining.CONCLUSION: The staining of TN-C predominantly showed notable dose-dependent heterogeneity, persisting for up to 1 year after completion of IRR. Thus, these findings can be attributed to late radiation effects. The altered expression of tenascin-C may play at least a partial role in late radiogenic dysfunction of the submandibular SG.

KW - Animals

KW - Dose Fractionation

KW - Dose-Response Relationship, Radiation

KW - Gene Expression Regulation

KW - Immune System

KW - Multivariate Analysis

KW - Rats

KW - Rats, Wistar

KW - Submandibular Gland

KW - Tenascin

KW - Time Factors

M3 - SCORING: Journal article

C2 - 20592347

VL - 30

SP - 1593

EP - 1598

JO - ANTICANCER RES

JF - ANTICANCER RES

SN - 0250-7005

IS - 5

ER -