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Exposure-response relationship between endotoxin exposure and lung function impairment in cotton textile workers.

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Exposure-response relationship between endotoxin exposure and lung function impairment in cotton textile workers. / Oldenburg, Marcus; Latza, Ute; Baur, Xaver.

in: INT ARCH OCC ENV HEA, Jahrgang 80, Nr. 5, 5, 2007, S. 388-395.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Oldenburg, M, Latza, U & Baur, X 2007, 'Exposure-response relationship between endotoxin exposure and lung function impairment in cotton textile workers.', INT ARCH OCC ENV HEA, Jg. 80, Nr. 5, 5, S. 388-395. <http://www.ncbi.nlm.nih.gov/pubmed/17051395?dopt=Citation>

APA

Oldenburg, M., Latza, U., & Baur, X. (2007). Exposure-response relationship between endotoxin exposure and lung function impairment in cotton textile workers. INT ARCH OCC ENV HEA, 80(5), 388-395. [5]. http://www.ncbi.nlm.nih.gov/pubmed/17051395?dopt=Citation

Vancouver

Oldenburg M, Latza U, Baur X. Exposure-response relationship between endotoxin exposure and lung function impairment in cotton textile workers. INT ARCH OCC ENV HEA. 2007;80(5):388-395. 5.

Bibtex

@article{bb9bff66c7b049b4b97afccddd8e4dcf,
title = "Exposure-response relationship between endotoxin exposure and lung function impairment in cotton textile workers.",
abstract = "OBJECTIVES: Preventive workplace regulations are so far not based on an ubiquitously accepted threshold for airborne endotoxin in the bioaerosol. METHODS: In a cross-sectional study, 150 employees of a cotton spinning mill underwent lung function testing. Furthermore, in a random subset of 75 textile workers cross-shift lung function test and methacholine challenges were performed. Airborne current endotoxin exposure was classified as {"}low{"}, {"}medium{"}, and {"}high{"} (100-450 Endotoxin Units (EU)/m(3), respectively) based on endotoxin activity. RESULTS: The exposure-response relationship between current endotoxin exposure and prevalence of an obstructive ventilation pattern was significant (test for linear trend: P = 0.019); the adjusted odds ratio for high endotoxin exposure was 11.22 (95% confidence interval 1.03-121.17). Within individuals, FEV(1)/FVC% was significantly reduced after the shift (paired t test: P = 0.009) but not related to current endotoxin exposure. Twelve workers showed bronchial hyperresponsiveness (8.1% before and 12.2% after the work shift; Fisher's exact test: P = 0.021). CONCLUSION: The study among German cotton textile workers suggests an exposure-dependent effect of current endotoxin exposure on lung function impairment with significant effects above 450 EU/m(3).",
author = "Marcus Oldenburg and Ute Latza and Xaver Baur",
year = "2007",
language = "Deutsch",
volume = "80",
pages = "388--395",
journal = "INT ARCH OCC ENV HEA",
issn = "0340-0131",
publisher = "Springer",
number = "5",

}

RIS

TY - JOUR

T1 - Exposure-response relationship between endotoxin exposure and lung function impairment in cotton textile workers.

AU - Oldenburg, Marcus

AU - Latza, Ute

AU - Baur, Xaver

PY - 2007

Y1 - 2007

N2 - OBJECTIVES: Preventive workplace regulations are so far not based on an ubiquitously accepted threshold for airborne endotoxin in the bioaerosol. METHODS: In a cross-sectional study, 150 employees of a cotton spinning mill underwent lung function testing. Furthermore, in a random subset of 75 textile workers cross-shift lung function test and methacholine challenges were performed. Airborne current endotoxin exposure was classified as "low", "medium", and "high" (100-450 Endotoxin Units (EU)/m(3), respectively) based on endotoxin activity. RESULTS: The exposure-response relationship between current endotoxin exposure and prevalence of an obstructive ventilation pattern was significant (test for linear trend: P = 0.019); the adjusted odds ratio for high endotoxin exposure was 11.22 (95% confidence interval 1.03-121.17). Within individuals, FEV(1)/FVC% was significantly reduced after the shift (paired t test: P = 0.009) but not related to current endotoxin exposure. Twelve workers showed bronchial hyperresponsiveness (8.1% before and 12.2% after the work shift; Fisher's exact test: P = 0.021). CONCLUSION: The study among German cotton textile workers suggests an exposure-dependent effect of current endotoxin exposure on lung function impairment with significant effects above 450 EU/m(3).

AB - OBJECTIVES: Preventive workplace regulations are so far not based on an ubiquitously accepted threshold for airborne endotoxin in the bioaerosol. METHODS: In a cross-sectional study, 150 employees of a cotton spinning mill underwent lung function testing. Furthermore, in a random subset of 75 textile workers cross-shift lung function test and methacholine challenges were performed. Airborne current endotoxin exposure was classified as "low", "medium", and "high" (100-450 Endotoxin Units (EU)/m(3), respectively) based on endotoxin activity. RESULTS: The exposure-response relationship between current endotoxin exposure and prevalence of an obstructive ventilation pattern was significant (test for linear trend: P = 0.019); the adjusted odds ratio for high endotoxin exposure was 11.22 (95% confidence interval 1.03-121.17). Within individuals, FEV(1)/FVC% was significantly reduced after the shift (paired t test: P = 0.009) but not related to current endotoxin exposure. Twelve workers showed bronchial hyperresponsiveness (8.1% before and 12.2% after the work shift; Fisher's exact test: P = 0.021). CONCLUSION: The study among German cotton textile workers suggests an exposure-dependent effect of current endotoxin exposure on lung function impairment with significant effects above 450 EU/m(3).

M3 - SCORING: Zeitschriftenaufsatz

VL - 80

SP - 388

EP - 395

JO - INT ARCH OCC ENV HEA

JF - INT ARCH OCC ENV HEA

SN - 0340-0131

IS - 5

M1 - 5

ER -