[Experiences with monoclonal antibody orthoclone OKT3 following liver transplantation]
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[Experiences with monoclonal antibody orthoclone OKT3 following liver transplantation]. / Kraemer-Hansen, H; Henne-Bruns, D; Schröder, S; Löning, Thomas; Dittmer, R; Kremer, B.
in: Z GASTROENTEROL, Jahrgang 29, Nr. 9, 9, 1991, S. 422-425.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - [Experiences with monoclonal antibody orthoclone OKT3 following liver transplantation]
AU - Kraemer-Hansen, H
AU - Henne-Bruns, D
AU - Schröder, S
AU - Löning, Thomas
AU - Dittmer, R
AU - Kremer, B
PY - 1991
Y1 - 1991
N2 - In 7 patients 10 cycles (5 to 21 days, dosage: 30 to 430 mg, median 138 mg) of OKT3 therapy were performed after liver transplantation. In all patients reactivation of an EBV-infection with hepatitis was observed. Two patients treated with high dosages (430 mg respectively 195 mg) developed lymphoproliferative lesions. In one patient with persistent EBV-infection (dosage: 360 mg) a B-cell-lymphoma was diagnosed. This patient died 26 months after transplantation.
AB - In 7 patients 10 cycles (5 to 21 days, dosage: 30 to 430 mg, median 138 mg) of OKT3 therapy were performed after liver transplantation. In all patients reactivation of an EBV-infection with hepatitis was observed. Two patients treated with high dosages (430 mg respectively 195 mg) developed lymphoproliferative lesions. In one patient with persistent EBV-infection (dosage: 360 mg) a B-cell-lymphoma was diagnosed. This patient died 26 months after transplantation.
M3 - SCORING: Zeitschriftenaufsatz
VL - 29
SP - 422
EP - 425
JO - Z GASTROENTEROL
JF - Z GASTROENTEROL
SN - 0044-2771
IS - 9
M1 - 9
ER -